Toward a New Future for Essential Oils

Napoli, Edoardo; Vito, Maura Di

doi:10.3390/antibiotics10020207

Cited by 17 publications

(13 citation statements)

References 27 publications

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“…Some EO components have some degree of toxicity, which limits their use as anthelmintics [ 48 ]. Therefore, the cytotoxic effects of free EO components, loaded PLGA, and CS-PLGA particles on adherent FKD-1-R were assessed at 6, 24, and 48 h using MTT assay.…”

Section: Discussionmentioning

confidence: 99%

Microfluidic-Based Formulation of Essential Oils-Loaded Chitosan Coated PLGA Particles Enhances Their Bioavailability and Nematocidal Activity

et al. 2022

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In this study, poly (lactic-co-glycolic) acid (PLGA) particles were synthesized and coated with chitosan. Three essential oil (EO) components (eugenol, linalool, and geraniol) were entrapped inside these PLGA particles by using the continuous flow-focusing microfluidic method and a partially water-miscible solvent mixture (dichloromethane: acetone mixture (1:10)). Encapsulation of EO components in PLGA particles was confirmed by Fourier transform infrared spectroscopy, thermogravimetric analysis, and X-ray diffraction, with encapsulation efficiencies 95.14%, 79.68%, and 71.34% and loading capacities 8.88%, 8.38%, and 5.65% in particles entrapped with eugenol, linalool, and geraniol, respectively. The EO components’ dissociation from the loaded particles exhibited an initial burst release in the first 8 h followed by a sustained release phase at significantly slower rates from the coated particles, extending beyond 5 days. The EO components encapsulated in chitosan coated particles up to 5 μg/mL were not cytotoxic to bovine gut cell line (FFKD-1-R) and had no adverse effect on cell growth and membrane integrity compared with free EO components or uncoated particles. Chitosan coated PLGA particles loaded with combined EO components (10 µg/mL) significantly inhibited the motility of the larval stage of Haemonchus contortus and Trichostrongylus axei by 76.9%, and completely inhibited the motility of adult worms (p < 0.05). This nematocidal effect was accompanied by considerable cuticular damage in the treated worms, reflecting a synergistic effect of the combined EO components and an additive effect of chitosan. These results show that encapsulation of EO components, with a potent anthelmintic activity, in chitosan coated PLGA particles improve the bioavailability and efficacy of EO components against ovine gastrointestinal nematodes.

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Section: Discussionmentioning

confidence: 99%

Microfluidic-Based Formulation of Essential Oils-Loaded Chitosan Coated PLGA Particles Enhances Their Bioavailability and Nematocidal Activity

et al. 2022

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“…In A. biebersteinii essential oil, the predominance of p-cymene, linalool, α-terpineol, terpinen-4-ol, and linalool acetate and in T. parthenium essential oil, the predominance of camphene, camphor, and bornyl acetate can be the most effective factors on this activity of essential oils. Many studies have confirmed the antimicrobial activity of these compounds against different strains [56,[105][106][107][108][109][110].…”

Section: Discussionmentioning

confidence: 99%

Tripleurospermum disciforme (C.A.Mey.) Sch.Bip., Tanacetum parthenium (L.) Sch.Bip, and Achillea biebersteinii Afan.: efficiency, chemical profile, and biological properties of essential oil

Ghavam

2021

Chem. Biol. Technol. Agric.

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Background Tripleurospermum disciforme (C.A.Mey.) Sch.Bip., Tanacetum parthenium (L.) Sch.Bip., and Achillea biebersteinii Afan. are the most important species of the Asteraceae family that are used in traditional medicine as antiseptics, analgesics, and anti-ulcers. This study aimed to evaluate and compare the yield, chemical profile, and antibacterial and antifungal properties of the essential oils of these three species for the first time. For this purpose, plant materials were collected in June 2019 from Javinan region (Kashan, Iran). Results Based on the ANOVA results the species had a significant effect on yield, chemical composition, and diameter of the inhibition zone of some microorganisms (P ≤ 0.01). The highest yield belonged to T. disciforme essential oil (~ 1.433%). Analysis of essential oil compounds showed that in T. disciforme, anisole, p-1-cyclohexen-1-yl- (55.95%), modephene (10.00%), and cis-β-farnesene (11.94%), in T. parthenium, camphor (43.43%), camphene (9.40%), and bornyl acetate (6.76%), and in A. biebersteinii linalool (34.49%), p-cymene (15.31%), and α-terpineol (7.43%) were the main and predominant compounds. The highest inhibition zone diameter by the essential oil of T. parthenium and A. biebersteinii against Aspergillus brasiliensis (~ 13 mm) was observed. The strongest inhibitory and lethal activity was related to T. disciforme essential oil against Klebsiella pneumoniae, Shigella dysenteriae, Escherichia coli (~ 8.50 mm), and Candida albicans (MIC and MBC = 62.5 μg/mL), which were equivalent to rifampin and twice as potent as nystatin, respectively. Conclusions Therefore, the essential oil of the studied species of Asteraceae may be a promising and potential strategy for controlling some microorganisms and a possible natural alternative to some antibiotics. Graphic Abstract

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“…Medicinal plants can be used fresh or dry, in the form of herbal tea, extract, essential oil, or pharmaceutical formulations (tablets, capsules, etc.). Plant essential oils possess a wide spectrum of biological activities, and are used in the food industry, but also in human and veterinary medicine [ 30 ]. Hydrolates (hydrosols and distillate waters) are byproducts of steam distillation.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antioxidant, and Antimicrobial Activity of Dracocephalum moldavica L. Essential Oil and Hydrolate

Aćimović

Šovljanski

Šeregelj

et al. 2022

Plants

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Steam distillation was used for the isolation of Dracocephalum moldavica L. (Moldavian dragonhead) essential oil (DMEO). This aromatic herbaceous plant is widespread across the Northern Hemisphere regions and has been utilized in health-improving studies and applications. In addition to the DMEO, the hydrolate (DMH), a byproduct of the distillation process, was also collected. The DMEO and DMH were analyzed and compared in terms of their chemical composition, as well as their in vitro biological activities. The main component in DMEO was geranyl acetate, while geranial was dominant in DMH. The DMEO demonstrated better antioxidant and antimicrobial activities compared with the DMH against Staphylococcus aureus, Escherichia coli, Salmonella Typhimurium, and Listeria monocytogenes, which represent sources of food-borne illness at the global level. The DMEO and DMH show promise as antioxidant and antimicrobial additives to various products.

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Toward a New Future for Essential Oils

Abstract: Essential oils (EOs) are peculiar phytocomplexes in the already widely varied world of natural bioactive substances [...]

Cited by 17 publications

References 27 publications

Microfluidic-Based Formulation of Essential Oils-Loaded Chitosan Coated PLGA Particles Enhances Their Bioavailability and Nematocidal Activity

Microfluidic-Based Formulation of Essential Oils-Loaded Chitosan Coated PLGA Particles Enhances Their Bioavailability and Nematocidal Activity

Tripleurospermum disciforme (C.A.Mey.) Sch.Bip., Tanacetum parthenium (L.) Sch.Bip, and Achillea biebersteinii Afan.: efficiency, chemical profile, and biological properties of essential oil

Chemical Composition, Antioxidant, and Antimicrobial Activity of Dracocephalum moldavica L. Essential Oil and Hydrolate

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