“…Overall, to the extent DA is considered a key agent subserving “signal fidelity” (Bäckman et al, 2010, 2006; Li et al, 2001) that provides a neurochemical basis for signal dynamics to emerge, the use of signal variability measures in any DA-relevant area of research is warranted (e.g., decision making/reward/learning/response vigor (Dayan and Walton, 2012; Doya, 2008; Montague et al, 2004; Niv et al, 2007; Niv and Schoenbaum, 2008); impulsivity/addiction (Bogdan et al, 2012; Hariri, 2009); working memory/cognitive control (Bäckman et al, 2010, 2006; Cools and D’Esposito, 2011); cognitive training (Bäckman et al, 2011; Bäckman et al, 2010)). The relevance of signal variability measures in schizophrenia research (see above, Fernandez et al, 2012), and the purported role of abnormal DA dynamics in this patient group, further motivates the examination of DA-signal variability links in clinical conditions.…”