2004
DOI: 10.1038/sj.mp.4001411
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Tourette syndrome and dopaminergic genes: a family-based association study in the French Canadian founder population

Abstract: Tourette syndrome (TS) is a genetically complex disorder for which no causative genes have been unequivocally identified. Nevertheless, a number of molecular genetic studies have investigated several candidate genes, particularly those implicated in dopamine modulation. The results of these studies were inconclusive, which may be due, at least in part, to the variable ethnicity of the patients included in different studies and the chosen research design. In this study, we used a family-based association approa… Show more

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Cited by 83 publications
(47 citation statements)
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“…Díaz-Anzaldúa et al 99 used the TDT approach, which has proven to be a robust family-based association analysis to investigate the implication of dopamine-related candidate genes (DRD2, DRD3, dopamine receptor type 4 gene -DRD4 -, dopamine transporter gene -SLC6A3 and MAOA) in 110 TS patients and their parents from French Canadian origin. The study reported that from the total MAOA-mVNTR "high-activity" alleles found in heterozygous parents, 68% were transmitted to the TS patient.…”
Section: Suicidal Behaviormentioning
confidence: 99%
“…Díaz-Anzaldúa et al 99 used the TDT approach, which has proven to be a robust family-based association analysis to investigate the implication of dopamine-related candidate genes (DRD2, DRD3, dopamine receptor type 4 gene -DRD4 -, dopamine transporter gene -SLC6A3 and MAOA) in 110 TS patients and their parents from French Canadian origin. The study reported that from the total MAOA-mVNTR "high-activity" alleles found in heterozygous parents, 68% were transmitted to the TS patient.…”
Section: Suicidal Behaviormentioning
confidence: 99%
“…phisms with variable tandem repeats have been implicated in the prevalence of several mental disorders, including attention deficit-hyperactivity disorder (ADHD) (10,11), Tourette syndrome (12), and substance abuse (13,14). Moreover, human studies suggest that the gene polymorphisms correlate with the PFC gray matter volume (15) and responsiveness to medication in ADHD patients (16).…”
mentioning
confidence: 99%
“…Although a significant association between the X-linked MAOA gene and TS phenotype has been identified by Gade et al (Sabol et al, 1998) in 1998 and MAOA-VNTR association with susceptibility to TS in French Canadian population by family-based study by Díaz-Anzaldúa et al (2004), large genetic association and linkage studies to date have failed to implicate MAOA gene as the cause of TS. Moreover, genetic variants with minor effects in association studies between complex inheritance disorders (including ADHD, TS, and OCD) and dopamine candidate genes often lead to contradictory results among different methods, populations and experimental designs (Zsofia, Anna, & Maria, 2011).…”
Section: Discussionmentioning
confidence: 91%