Tough interpenetrating Pluronic F127/polyacrylic acid hydrogels

Baskan, Tuba; Tuncaboylu, Deniz Ceylan; Okay, Oğuz

doi:10.1016/j.polymer.2013.03.066

Cited by 34 publications

(25 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They have been widely used as in situ forming carrier due to their unique sol–gel transition behavior in aqueous solution in response to temperature change at skin (32 °C) and body temperature (37 °C) [1]. At room temperature (< 30 °C), the aqueous solutions remain in sol state; however, at certain temperature (> LCST, 32 °C) and concentration, it converts into gel form forming a depot system [40]. Pluronics are FDA-approved biocompatible polymer for oral, injectable, topical, inhalation, and ophthalmic preparation [3, 41].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of microneedles-assisted in situ depot forming poloxamer gels for sustained transdermal drug delivery

Khan

Minhas

Tekko

et al. 2019

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

In this study, for the first time, we have reported a sustained transdermal drug delivery from thermoresponsive poloxamer depots formed within the skin micropores following microneedle (MN) application. Firstly, we have investigated the sol–gel phase transition characteristics of poloxamers (PF®127, P108, and P87) at physiological conditions. Rheological measurements were evaluated to confirm the critical gelation temperature (CGT) of the poloxamer formulations with or without fluorescein sodium (FS), as a model drug, at various concentrations. Optimized poloxamer formulations were subjected to in vitro release studies using a vial method. Secondly, polymeric MNs were fabricated using laser-engineered silicone micromolds from various biocompatible polymeric blends of Gantrez S-97, PEG 10000, PEG200, PVP K32, and PVP K90. The MN arrays were characterized for mechanical strength, insertion force determination, in situ dissolution kinetics, moisture content, and penetration depth. The optimized MN arrays with good mechanical strength and non-soluble nature were used to create micropores in the neonatal porcine skin. Microporation in neonatal porcine skin was confirmed by dye-binding study, skin integrity assessment, and histology study. Finally, the in vitro delivery of FS from optimized poloxamer formulations was conducted across non-porated vs microporated skin samples using vertical Franz diffusion cells. Results concluded that permeation of FS was sustained for 96 h across the MN-treated skin samples containing in situ forming depot poloxamer formulations compared to non-microporated skin which sustained the FS delivery for 72 h. Confocal microscopic images confirmed the distribution of higher florescence intensity of FS in skin tissues after permeation study in case of MN-treated skin samples vs intact skin samples. Electronic supplementary material The online version of this article (10.1007/s13346-019-00617-2) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of microneedles-assisted in situ depot forming poloxamer gels for sustained transdermal drug delivery

Khan

Minhas

Tekko

et al. 2019

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

show abstract

“…Usually, redox-initiators such as ammonium persulfate (APS) along with N,N,N 0 ,N 0 -tetramethylethylenediamine (TEMED) or APS along with sodium metabisulfite (SMS) are used to initiate the reactions at ambient temperatures. Because the Krafft point for CTAB in water is around 20-25 C [59], the reactions in CTAB solutions are carried out at elevated temperatures, [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] C. As a result of the high concentration of hydrophobic monomer within the micelles, the hydrophobes are randomly distributed as blocks along the hydrophilic polymer chains. The number of hydrophobic monomeric units per hydrophobic block (N H ) and the number of blocks per chain (S n ) can be estimated from the molar concentration ratio of hydrophobic monomer (HM) to the surfactant (S) by:…”

Section: Preparation Of Hydrophobically Modified Hydrogelsmentioning

confidence: 99%

Self-Healing Hydrogels Formed via Hydrophobic Interactions

Okay

2015

Supramolecular Polymer Networks and Gels

Self Cite

View full text Add to dashboard Cite

“…Such gels can exhibit strong pH-responsive or electrolyte-responsive swelling. [14][15][16][17][18][19][20] They also offer potential biomaterial applications, because the pH-triggered swelling transition can be tuned to correspond to physiological conditions, especially for gels based on methacrylic acid (MAA). [21][22][23][24] Whilst excellent mechanical properties have been reported for such gels, 25 one common limitation in the context of biomaterials applications is that gel construction methods rely on the use of small molecule monomers.…”

Section: Introductionmentioning

confidence: 99%

“…[21][22][23][24] Whilst excellent mechanical properties have been reported for such gels, 25 one common limitation in the context of biomaterials applications is that gel construction methods rely on the use of small molecule monomers. 14,[17][18][19][20][25][26][27][28][29][30][31][32] In this study we introduce a new generic approach that enables the rational design of highly deformable pH-responsive hydrogels using aqueous dispersions of pre-formed polyacid NPs as the only gel building blocks.…”

Section: Introductionmentioning

confidence: 99%

Highly deformable hydrogels constructed by pH-triggered polyacid nanoparticle disassembly in aqueous dispersions

Wang

Zhu

et al. 2018

Soft Matter

View full text Add to dashboard Cite

Most hydrogels are prepared using small-molecule monomers but unfortunately this approach may not be feasible for certain biomaterial applications. Consequently, alternative gel construction strategies have been established, which include using covalent inter-linking of preformed gel particles, or microgels (MGs). For example, covalently interlinking pH-responsive MGs can produce hydrogels comprising doubly crosslinked microgels (DX MGs). We hypothesised that the deformability of such DX MGs was limited by the presence of intra-MG crosslinking. Thus, in this study we designed new nanoparticle (NP)-based gels based on pH-swellable NPs that are not internally crosslinked. Two polyacid NPs were synthesised containing methacrylic acid (MAA) and either ethyl acrylate (EA) or methyl methacrylate (MMA). The PMAA-EA and PMAA-MMA NPs were subsequently vinyl-functionalised using glycidyl methacrylate (GMA) prior to gel formation via free-radical crosslinking. The NPs mostly disassembled on raising the solution pH but some self-crosslinking was nevertheless evident. The gels constructed from the EA- and MMA-based NPs had greater breaking strains than a control DX MG. The effect of varying the solution pH during curing on the morphology and mechanical properties of gels prepared using PMAA-MMA-GMA NPs was studied and both remarkable deformability and excellent recovery were observed. The gels were strongly pH-responsive and had tensile breaking strains of up to 420% with a compressive strain-at-break of more than 93%. An optimised formulation produced the most deformable and stretchable gel yet constructed using NPs or MGs as the only building block.

show abstract

Tough interpenetrating Pluronic F127/polyacrylic acid hydrogels

Cited by 34 publications

References 40 publications

Evaluation of microneedles-assisted in situ depot forming poloxamer gels for sustained transdermal drug delivery

Evaluation of microneedles-assisted in situ depot forming poloxamer gels for sustained transdermal drug delivery

Self-Healing Hydrogels Formed via Hydrophobic Interactions

Highly deformable hydrogels constructed by pH-triggered polyacid nanoparticle disassembly in aqueous dispersions

Contact Info

Product

Resources

About