Tough and biodegradable polyurethane-curcumin composited hydrogel with antioxidant, antibacterial and antitumor properties

Feng, Yuan Ping; Xiao, Kecen; He, Yuanyuan; Du, Bohong; Hong, Jianghui; Yin, Hang; Lu, Dan; Luo, Feng; Li, Zhen; Li, Jiehua; Tan, Hong; Fu, Qiang

doi:10.1016/j.msec.2020.111820

Cited by 36 publications

(23 citation statements)

References 39 publications

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“…Nevertheless, the viscosity of such systems can prevent the efficiency of PDT by decreasing the photostability and ROS production, thus calling for further optimizations [327,328]. Furthermore, the incorporation of hydrophobic PSs such as curcumin in polyurethane hydrogel has demonstrated to be an efficient PS release system [329].…”

Section: Polymeric Nps and Nanocompositesmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

et al. 2021

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Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern therapeutics, notably due to the expanding versatility of photosensitizers (PSs) and the numerous possibilities to combine aPDT with other antimicrobial treatments to combat localized infections. After revisiting the basic principles of aPDT, this review first highlights the current state of the art of curative or preventive aPDT applications with relevant clinical trials. In addition, the most recent developments in photochemistry and photophysics as well as advanced carrier systems in the context of aPDT are provided, with a focus on the latest generations of efficient and versatile PSs and the progress towards hybrid-multicomponent systems. In particular, deeper insight into combinatory aPDT approaches is afforded, involving non-radiative or other light-based modalities. Selected aPDT perspectives are outlined, pointing out new strategies to target and treat microorganisms. Finally, the review works out the evolution of the conceptually simple PDT methodology towards a much more sophisticated, integrated, and innovative technology as an important element of potent antimicrobial strategies.

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Section: Polymeric Nps and Nanocompositesmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

et al. 2021

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“…The amphiphilic properties of PU enable hydrophobic drugs to be loaded efficiently and quickly [ 154 ]. Feng et al synthesized PU/curcumin hydrogels by in situ copolymerization, PU-Cur hydrogels not only retain their physical and chemical properties and functions but also improves the mechanical strength of the PU hydrogels and promotes rapid wound healing [ 155 ]. However, PU hydrogels often have disadvantages such as poor hydrophilic properties leading to weak lubricating properties, and cross-linking agents or initiators required for preparation by radiation or chemical cross-linking are toxic and difficult to remove.…”

Section: Biomaterials For Preparing Hydrogelsmentioning

confidence: 99%

Hydrogel Preparation Methods and Biomaterials for Wound Dressing

Liang

et al. 2021

Life

129

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Wounds have become one of the causes of death worldwide. The metabolic disorder of the wound microenvironment can lead to a series of serious symptoms, especially chronic wounds that bring great pain to patients, and there is currently no effective and widely used wound dressing. Therefore, it is important to develop new multifunctional wound dressings. Hydrogel is an ideal dressing candidate because of its 3D structure, good permeability, excellent biocompatibility, and ability to provide a moist environment for wound repair, which overcomes the shortcomings of traditional dressings. This article first briefly introduces the skin wound healing process, then the preparation methods of hydrogel dressings and the characteristics of hydrogel wound dressings made of natural biomaterials and synthetic materials are introduced. Finally, the development prospects and challenges of hydrogel wound dressings are discussed.

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“…Other polymers, such as polyurethane, poly(vinylpyrrolidone), and poly-2-dimethylamino ethyl methacrylate, are also optional materials for preparing hydrogels for PDT. [47][48][49] Feng et al directly composite hydrophobic curcumin (Cur) and polyurethane (PU) through a simple in situ hybridization method, which eradicated the dilemma that hydrophobic functional drugs cannot be combined with hydrogels. [47] Nayak et al simultaneously conjugated DNA and PVP polymers into a single carbon quantum dot (CD) to make a DNA-CD-PVP hybrid hydrogel that is pH-responsive.…”

Section: Synthetic Network Hydrogelsmentioning

confidence: 99%

“…[47][48][49] Feng et al directly composite hydrophobic curcumin (Cur) and polyurethane (PU) through a simple in situ hybridization method, which eradicated the dilemma that hydrophobic functional drugs cannot be combined with hydrogels. [47] Nayak et al simultaneously conjugated DNA and PVP polymers into a single carbon quantum dot (CD) to make a DNA-CD-PVP hybrid hydrogel that is pH-responsive. [48] Xi et al prepared a natural antibiotic (aloe-emodin, AE) and a carbon nanoparticle coembedded poly-2-dimethylaminoethyl methacrylate hydrogel as a new type of wound dressing for the treatment of infected wounds.…”

Section: Synthetic Network Hydrogelsmentioning

confidence: 99%

Hydrogel Combined with Phototherapy in Wound Healing

Chen

Ying

et al. 2022

Adv Healthcare Materials

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Wound healing is a complex biological process that involves tissue regeneration. Traditional wound dressings are dry, cannot provide a moist environment for wound healing, and do not have high antibacterial properties. Hydrogels, which are capable of retaining large amounts of water, can create a moist healing environment. Currently, phototherapies have exhibited a high potential for the treatment of bacterial infections. Therefore, combining hydrogels with phototherapy can adequately overcome the shortcomings of traditional wound treatment methods and show great potential for wound healing owing to their high efficiency, low irritation, and good antibacterial performance. In this review, the application of hydrogels combined with phototherapy in wound healing is summarized. First, the basic principles of photodynamic therapy and photothermal therapy are briefly introduced. In addition, the progress of the application of hydrogel combined with phototherapy in wound healing is systematically investigated. Finally, the challenges and prospects of combining hydrogel with phototherapy in wound healing are discussed.

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Tough and biodegradable polyurethane-curcumin composited hydrogel with antioxidant, antibacterial and antitumor properties

Cited by 36 publications

References 39 publications

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Hydrogel Preparation Methods and Biomaterials for Wound Dressing

Hydrogel Combined with Phototherapy in Wound Healing

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