Totalsynthese von Hexaacetylcelenamid A

Schmidt, Ulrich; Wild, Jochen

doi:10.1002/ange.19840961234

Cited by 14 publications

(4 citation statements)

References 9 publications

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“…The latter type has been much less studied, since phosphoamino acid group is difficult to introduce at certain internal positions of polypeptides. Peptidomimetics of this kind were applied to the synthesis of natural peptide compounds [7][8][9][10][11][12][13], thus adding to the biological significance of phosphopeptide mimetics.…”

Section: Introductionmentioning

confidence: 99%

1,3-Oxazoles as precursors of phosphorylated amino acids and peptidomimetics

et al. 2022

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The design and development of new phosphorus-containing amino acids and peptidomimetics have been attracting considerable attention due to their value as intermediates in the synthesis of biologically active compounds and the prospects for further pharmacological applications. 1,3-Oxazole derivatives, as masked peptides, constitute an important group of amino acid precursors that are widely used in contemporary organic synthesis. This review presents the 1,3-oxazole-based synthetic strategies of phosphorylated amino acids and peptides that have been published in both journal and patent literature. We have focused specifically on the synthesis of 4-phosphorylated 1,3-oxazoles as precursors of phosphopeptide mimetics containing the peptide chain with a non-terminal phosphono group due to the growing interest in finding efficient methods for the synthesis of this little-studied class of compounds

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Section: Introductionmentioning

confidence: 99%

1,3-Oxazoles as precursors of phosphorylated amino acids and peptidomimetics

et al. 2022

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“…Phosphorylated peptides are also valuable intermediates in the synthesis of some biologically active compounds. To illustrate, they enabled synthesis of iron and mollusk vanadium-containing blood pigment -Tunichromes Mm-1 and Mm-2, 27,28 peptide alkaloid Hexaacetylcelenamid A, 29,30 potential anticancer agents -Azinomycins A and B, 31,32 antibiotic Antrimycin DV, 33 and others.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel phosphorylated peptidomimetics which contain ω-haloalkyl and ω-thiocyanoethyl residues

Golovchenko¹,

Abdurakhmanova²,

Brusnakov³

et al. 2020

10.5267/j.ccl

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“…They have been employed in the synthesis of peptide natural products, e.g. azinomycins A and B, 14 (AE)-tunichrome An-1, 15 tunichromes Mm-1 and Mm-2, 16 hexaacetylcelenamide A, 17,18 clionamide, 19 etc. Also, some compounds of this class are effective glutathione transferase inhibitors.…”

Section: Introductionmentioning

confidence: 99%