Totally synthetic peptide-based immunocontraceptive vaccines show activity in dogs of different breeds

Walker, John; Ghosh, Souravi; Pagnon, Joanne; Colantoni, C; Newbold, Andrea; Zeng, Weiguang; Jackson, David C.

doi:10.1016/j.vaccine.2007.07.047

Cited by 31 publications

(26 citation statements)

References 26 publications

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“…; Walker et al. ). A commercially manufactured GnRH vaccine in the United States (Canine Gonadotropin Releasing Factor Immunotherapeutic ® ; Pfizer Animal Health, Exton, PA, USA; referred to in this manuscript as a ‘commercial canine GnRH vaccine’), labelled for the twice‐annual management of benign prostatic hyperplasia in intact male dogs, may also be an ideal option for a reversible means of immunocastration.…”

Section: Introductionmentioning

confidence: 99%

Physiologic Responses Following Gonadotropin‐Releasing Hormone Immunization in Intact Male Dogs

Donovan

Greer²,

Kutzler³

2012

Reprod Domestic Animals

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We investigated the use of a commercial gonadotropin-releasing hormone (GnRH) vaccine as a method of temporary and reversible immunocastration in intact male dogs. Four privately owned dogs were vaccinated twice at 4-week intervals. Blood samples were collected at 0, 4, 12 and 20 weeks following the initial vaccination. These samples were analysed for GnRH antibody titres, luteinizing hormone (LH) and testosterone concentrations. Scrotal measurements were made at the time of sample collection, and testicular volume was calculated using the formula of an ellipsoid. As a result of vaccination, dogs displayed an elevated GnRH antibody titre, decreased LH and testosterone concentrations and decreased testicular volume, which reversed by the end of the study period. Therefore, these results suggest that immunizing against GnRH may be a possible choice for temporary and reversible immunocastration.

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Section: Introductionmentioning

confidence: 99%

Physiologic Responses Following Gonadotropin‐Releasing Hormone Immunization in Intact Male Dogs

Donovan

Greer²,

Kutzler³

2012

Reprod Domestic Animals

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“…Besides being reversible it could potentially be used in both genders. Once again, investigations in Domestic dogs have yielded positive results (♂ dogs, Jung et al , 2005; ♂ and ♀ dogs, Walker et al , 2007) with a possible application to wild canids in the future.…”

Section: Introductionmentioning

confidence: 99%

Reproductive management in captive and wild canids: contraception challenges

Boutelle

Bertschinger

2010

International Zoo Yearbook

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“… and Walker et al. ). Fusion of canine GnRH and the T‐helper cell epitope p35 originating from canine distemper virus F protein (Jung et al.…”

Section: Immunosterilization/immunocontraceptionmentioning

confidence: 97%

Suppression of Fertility in Adult Dogs

Maenhoudt

Santos

Fontbonne

2014

Reprod Domestic Animals

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Contents Unfortunately, the overpopulation of dogs is still a problem in the majority of countries and even though surgical methods of sterilization, the most traditional and commonly used technique, have been intensively performed, the impact on the dog population is negligible. The neutering of companion animals as ovariohysterectomy (spaying) or orchidectomy (castration) has its limitations because of the cost, the need of a surgical environment and the risk of surgical and/or anaesthetical complications (ACCD 2009). In fact, surgical castration has been banished in some northern European countries and has limited acceptance in other countries. In a survey performed in Sao Paulo, Brazil, 56.5% of the owners of adopted shelter dogs were against the surgical procedure for different reasons (Soto et al. 2005). Currently, the options for contraception, defined as suppression of fertility are based on hormonal treatment. The treatments can be divided into analogues of gonadotropin releasing hormone (GnRH), progestins and androgens. Other possibilities of contraception are via the immunological system with vaccinations against GnRH, the luteinizing hormone (LH) receptor and the zona pellucida proteins. Finally, there is also the intra‐epididymal or intratesticular injection of sclerosing substances in dogs. Mechanical devices to disrupt fertility are not used anymore due to the side effects. Suppression of fertility in adult dogs will be reviewed in order of use and possible impact on the dog population.

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Totally synthetic peptide-based immunocontraceptive vaccines show activity in dogs of different breeds

Cited by 31 publications

References 26 publications

Physiologic Responses Following Gonadotropin‐Releasing Hormone Immunization in Intact Male Dogs

Physiologic Responses Following Gonadotropin‐Releasing Hormone Immunization in Intact Male Dogs

Reproductive management in captive and wild canids: contraception challenges

Suppression of Fertility in Adult Dogs

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