Total thyroidectomy versus thyroid lobectomy for papillary thyroid cancer: Comparative analysis after propensity score matching—A multicenter study.

Kuba, Sayaka; Yamanouchi, Kaoru; Hayashida, Naomi; Maeda, Shuichi; Sakimura, Chika; Kawakami, Fusako; Yano, Hiroshi; Matsumoto, Megumi; Otsubo, Ryota; Sato, Shuntaro; Fujioka, Hikaru; Kuroki, Tamotsu; Nagayasu, Takeshi; Eguchi, Susumu

doi:10.1200/jco.2016.34.15_suppl.e17556

Cited by 19 publications

(24 citation statements)

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“…Vaisman et al [22] did not clearly describe the number of patients who underwent central neck dissection, although the authors reported that they did not routinely perform prophylactic central neck dissection; therefore, their study was classified as having a high risk of bias in confounding variables. Studies by Kuba et al [12] and Matsuzu et al [16] did not report lymph node metastasis in the central and lateral compartments separately. Park et al [18] did not report recurrence in the contralateral thyroid and, in one study by Vaisman et al [22], the follow-up period was too short (12 months; range, 3-28 months), making it difficult to calculate the true recurrence rate.…”

Section: Resultsmentioning

confidence: 93%

“…1). Table 1 summarizes the outcomes of the 14 studies that were ultimately included in the analysis [10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Two studies investigated the impact of prophylactic central neck dissection in hemithyroidectomy using a comparative method [11,19].…”

Section: Resultsmentioning

confidence: 99%

“…Two studies investigated the impact of prophylactic central neck dissection in hemithyroidectomy using a comparative method [11,19]. Six investigations compared oncological results between total thyroidectomy and hemithyroidectomy in various subjects; however, only the data regarding hemithyroidectomy were included in the present study [10,12,13,20,21,23]. Others compared recurrence according to various factors among patients who underwent hemithyroidectomy [14][15][16][17][18]22].…”

Section: Resultsmentioning

confidence: 99%

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The Effect of Prophylactic Central Neck Dissection During Hemithyroidectomy on Locoregional Recurrence in Patients With Papillary Thyroid Carcinoma: A Meta-Analysis

Ahn

Kim

2020

Clin Exp Otorhinolaryngol

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Objectives. Hemithyroidectomy is commonly performed in patients with low- to intermediate-risk papillary thyroid carcinoma. The purpose of this meta-analysis was to evaluate the effect of prophylactic central neck dissection on locoregional recurrence in patients undergoing hemithyroidectomy.Methods. A meta-analysis was performed of full-text publications published in English retrieved from the Embase database.Results. The rate of regional recurrence in the central compartment after hemithyroidectomy, with or without prophylactic central neck dissection, was 0.17% and 1.78%, respectively. This difference was statistically significant. Recurrence in the lateral compartment or contralateral thyroid was not affected by prophylactic central neck dissection; the overall rate of recurrence was 1.3% and 5.4%, respectively.Conclusion. Prophylactic central neck dissection significantly reduced the risk of recurrence in the central compartment in patients undergoing hemithyroidectomy.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The Effect of Prophylactic Central Neck Dissection During Hemithyroidectomy on Locoregional Recurrence in Patients With Papillary Thyroid Carcinoma: A Meta-Analysis

Ahn

Kim

2020

Clin Exp Otorhinolaryngol

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“…Papillary thyroid carcinoma (PTC) is the most common histological type of differentiated thyroid malignancy and is considered to be the least aggressive of the thyroid carcinomas, given a 5‐year survival rate of over 95% . Despite the dramatic rise in incidence, the mortality rate of patients with PTC remains stable, at approximately 0.5 per 100,000 people …”

Section: Introductionmentioning

confidence: 99%

The optimal surgical approach for papillary thyroid carcinoma with pathological n1 metastases: An analysis from the SEER database

Chen

Mou

et al. 2019

The Laryngoscope

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Objectives/Hypothesis: The definition of large-volume pathologic N1 metastases has been changed in the 2017 version 2 of the National Comprehensive Cancer Network guidelines, leading to a controversy over the optimal surgical approach selection for patients with biopsy-proven papillary thyroid carcinoma (PTC). The aim of this study was to investigate the therapeutic efficacy of total thyroidectomy (TT) and thyroid lobectomy (TL) for these patients.Study Design: Retrospective population-based database analysis.Methods: A total of 906 consecutive PTC patients with pathologic N1 metastases (>5 involved nodes with metastases ≤5 mm in the largest dimension) were retrieved from the Surveillance, Epidemiology, and End Results database, and divided into two groups (≤2 mm, >2-5 mm) based on the size of the extent of disease. Overall survival (OS) was then compared between patients treated with TT and TL, followed by Cox proportional hazards regression analysis to explore multiple prognostic factors.Results: OS favored TT compared with TL in patients with more than five involved nodes and metastases >2 to 5 mm in the largest dimension (P < .05). Cox analysis showed that the TL was not an independent factor associated with poorer OS than TT in these patients (P > .05).Conclusions: TT showed better survival than TL for patients with more than five involved nodes and metastases >2 to 5 mm in the largest dimension. For patients with more than five involved nodes and metastases ≤2 mm in the largest dimension, either TT or TL can be recommended because there was no difference in survival.

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“…Routine RAI ablation was not possible because of strict regulation of radioactive substances, and total thyroidectomy is also not routinely performed [19]. Instead, lobectomy without RAI ablation is the preferred treatment for PTC patients without high-risk features [20]; while RAI ablation tends to be restored to high-risk patients only, which usually required a higher RAI doses. However, the increasing RAI demand is not offset by the number of available isolation ward which on the contrary, decreased [21].…”

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confidence: 99%

Determining patient selection tool and response predictor for outpatient 30 mCi radioiodine ablation dose in non-metastatic differentiated thyroid carcinoma: a Japanese perspective

et al. 2018

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Abstract. The lack of isolation ward throughout Japan has long been limiting the 131 I radioactive iodine (RAI) ablation for differentiated thyroid cancer (DTC) cases. The 30 mCi RAI ablation was only recently permitted for outpatient basis. However, no patient selection tool nor response predictor has been proposed. This study evaluated factors to find response predictor and determinant for the suitable patients. The retrospective study reviewed 47 eligible non-metastatic papillary DTC patients whose had first 30 mCi RAI ablation after total thyroidectomy. Age, gender, clinical stage, risk category, and preablation serum thyroglobulin (Tg) level were among covariates analyzed to determine the patient selection factors; while the thyroid bed uptake on initial whole body scan (WBS) was later also included in determining RAI ablation response. Thirteen (28%) patients had a low risk (T1-2) while 23 (49%) and 11 (23%) had an intermediate (T3) or high risk (T4), respectively. Twenty-five patients were responders, and 22 were non-responders. All factors were similar between responders and nonresponders except pre-ablation serum Tg level (p < 0.001). In multivariate analysis, pre-ablation serum Tg level was the only significant factor for both patient selection (odd ratio (OR) = 1.52, 95% confidence interval (CI) = 1.13-2.06) and response predictor (OR = 1.48; 95% CI = 1.12-1.95). With the cut-off of 5.4 ng/mL, pre-ablation serum Tg level predicts RAI ablation response with 92% specificity and 73% sensitivity. Pre-ablation serum Tg level may help patient selection and predict the response to outpatient 30 mCi RAI ablation among post total thyroidectomy non-metastatic DTC patients.

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Total thyroidectomy versus thyroid lobectomy for papillary thyroid cancer: Comparative analysis after propensity score matching—A multicenter study.

Cited by 19 publications

References 0 publications

The Effect of Prophylactic Central Neck Dissection During Hemithyroidectomy on Locoregional Recurrence in Patients With Papillary Thyroid Carcinoma: A Meta-Analysis

The Effect of Prophylactic Central Neck Dissection During Hemithyroidectomy on Locoregional Recurrence in Patients With Papillary Thyroid Carcinoma: A Meta-Analysis

The optimal surgical approach for papillary thyroid carcinoma with pathological n1 metastases: An analysis from the SEER database

Determining patient selection tool and response predictor for outpatient 30 mCi radioiodine ablation dose in non-metastatic differentiated thyroid carcinoma: a Japanese perspective

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