The Effect of Prophylactic Central Neck Dissection During Hemithyroidectomy on Locoregional Recurrence in Patients With Papillary Thyroid Carcinoma: A Meta-Analysis

Abstract

Objectives. Hemithyroidectomy is commonly performed in patients with low- to intermediate-risk papillary thyroid carcinoma. The purpose of this meta-analysis was to evaluate the effect of prophylactic central neck dissection on locoregional recurrence in patients undergoing hemithyroidectomy.Methods. A meta-analysis was performed of full-text publications published in English retrieved from the Embase database.Results. The rate of regional recurrence in the central compartment after hemithyroidectomy, with or without prophylactic central neck dissection, was 0.17% and 1.78%, respectively. This difference was statistically significant. Recurrence in the lateral compartment or contralateral thyroid was not affected by prophylactic central neck dissection; the overall rate of recurrence was 1.3% and 5.4%, respectively.Conclusion. Prophylactic central neck dissection significantly reduced the risk of recurrence in the central compartment in patients undergoing hemithyroidectomy.

Prophylactic Central Lymph Node Dissection Improves Disease-Free Survival in Patients with Intermediate and High Risk Differentiated Thyroid Carcinoma: A Retrospective Analysis on 399 Patients

“…These findings are in accordance with a recent meta-analysis by Zhao et al, which included 22 studies with over 6000 patients, where pCLND proved to be effective in reducing the risk of loco-regional recurrence [34]; another meta-analysis regarding pCNLD in patients who underwent hemithyroidectomy was consistent with this result [35].…”

Risk Factors for Central Lymph Node Metastases and Benefit of Prophylactic Central Lymph Node Dissection in Middle Eastern Patients With cN0 Papillary Thyroid Carcinoma

“…This is of high clinical importance since it shows the benefit from aggressive surgery in modifying the outcome of the disease and significantly improved the recurrence free survival in Middle Eastern PTC patients, where recurrence rate is relatively high. In concordance with our findings, two previous meta-analyses conducted on PTC patients from different ethnicity have shown that PCLND is beneficial in reducing risk of recurrence ( 51 , 52 ).…”

Protective Effect of Alpha-Lipoic Acid on Salivary Dysfunction in a Mouse Model of Radioiodine Therapy-Induced Sialoadenitis

“…Although thyroid cancer surgery has advanced [32][33][34][35][36][37], patients with differentiated thyroid cancer undergo high-dose RI treatment to achieve complete ablation of thyroid remnants following total thyroidectomy. Therapeutic RI exposure, such as exposure to 131 I, is known to generate oxidative stress and cause cellular damage in target organs [38].…”