Total Thyroidectomy for Cancer of the Thyroid: Significance of Intraglandular Dissemination

Clark, R. Lee; White, Edgar C.; Russell, William O.

doi:10.1097/00000658-195906000-00009

Cited by 141 publications

(36 citation statements)

References 3 publications

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“…patients and up to 87% in other studies; 8,19 (2) an extremely high rate of involvement of the pre-and paratracheal lymph nodes of 80% in our series and up to 90% in other series; 5,16 and (3) finally, this age group of patients has a long life expectancy, and we believe that such an aggressive approach would improve prognosis.…”

supporting

confidence: 57%

Surgery of thyroid cancer in children and adolescents

et al. 1998

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supporting

confidence: 57%

Surgery of thyroid cancer in children and adolescents

et al. 1998

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“…The reported frequency is about 20%, with wide variations depending on the extent of the sampling and reporting by the pa-thologist [1][2][3] . Multifocal papillary thyroid carcinomas (PTC) can be divided into 2 categories depending on the tumor size: multifocal papillary microcarcinoma (all of the lesions sized <1 cm) and multifocal macroscopic papillary thyroid cancer (includes more than 1 tumor focus sized ≥ 1 cm).…”

Section: Introductionmentioning

confidence: 99%

Patients with Multifocal Macroscopic Papillary Thyroid Carcinoma Have a Low Risk of Recurrence at Early Follow-Up after Total Thyroidectomy and Radioactive Iodine Treatment

Greca¹,

Xu²,

Ghossein³

et al. 2016

Eur Thyroid J

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Background: Multifocal thyroid cancer involvement is a common presentation in papillary thyroid cancer. The risk of recurrence of intrathyroidal multifocal papillary microcarcinoma (<1 cm) is documented to be low. However, the risk of recurrence of multifocal macroscopic thyroid cancer is not known. Prior studies have suggested that both the number of foci and the presence of nodal involvement at diagnosis are important predictors of recurrence in multifocal papillary thyroid carcinoma (PTC). Objectives: In this retrospective review of 99 patients presenting with multifocal macroscopic PTC (with 2 tumor foci >1 cm) without gross extrathyroidal extension, we examined the clinical outcomes of patients in the first 2 years after the initial therapy and at the end of the follow-up period (median: 5 years). Results: Half of the patients presenting with multifocal macroscopic PTC had nodal involvement at diagnosis. Only 4 patients had a recurrence on long-term follow-up, all with classic or tall-cell variant PTC with bulky nodal involvement at diagnosis. The number of tumor foci did not influence the risk of recurrence in this cohort. The median time to recurrence in these 4 patients was 11 years, with all patients having a recurrence after 9 years of follow-up. None of patients developed distant metastasis or died from thyroid cancer. Conclusions: Patients presenting with multifocal macroscopic papillary thyroid cancer without bulky nodal involvement or gross extrathyroidal extension have a low risk of thyroid cancer recurrence.

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“…Recent reports of improved prognosis after more extensive operations further advocate total thyroidectomy (13). The main argument against total thyroidectomy has been the hazard of a higher complication rate.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Carcinoma

Grimelius

Johansson

Nilsson

et al. 1978

Upsala Journal of Medical Sciences

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During the years 1969-1975, 58 patients were treated for thyroid carcinoma. 48 patients had differentiated and 10 had anaplastic carcinomas. The material is presented with special attention given to diagnostic methods and treatment for the differentiated forms. The value of cytological examination of fine needle biopsy is clearly documented. 40 patients with differentiated carcinomas were treated with total thyroidectomy, with low complication rate. Accidental persistent recurrent nerve paralysis as well as persistent hypoparathyroidism occurred in less than 3 %, Subdivision of papillary and follicular carcinomas on the hasis of their local growth pattern is emphasized as being of value in the determination of subsequent therapy.

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Total Thyroidectomy for Cancer of the Thyroid: Significance of Intraglandular Dissemination

Cited by 141 publications

References 3 publications

Surgery of thyroid cancer in children and adolescents

Surgery of thyroid cancer in children and adolescents

Patients with Multifocal Macroscopic Papillary Thyroid Carcinoma Have a Low Risk of Recurrence at Early Follow-Up after Total Thyroidectomy and Radioactive Iodine Treatment

Thyroid Carcinoma

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