“…5 Additionally, largazole ( 1 ) has shown a variety of other biological activities, such as the in vitro and in vivo induction of osteoblast differentiation biomarkers, 6 the sensitization of EBV+ tumor cells to the anti-herpes drug ganciclovir (GCV), 7 the inhibition of ubiquitin activating enzyme, E1, 8 and the in vitro and in vivo induction of apoptosis in hepatic stellate cells (HSC) in liver fibrosis models. 9 These promising biological activities led to 11 total syntheses 2,3,10–18 and a wide variety of analogues of largazole ( 1 ). 2–4,10,12,13,16,18–27 …”