Total syntheses of marchantin A and riccardin B, cytotoxic bis(bibenzyls) from liverworts

Cyclic bisbibenzyls induce growth arrest and apoptosis of human prostate cancer PC3 cells

“…Recently, bisbibenzyls are gaining much more attention for their cytotoxic effects and anti-tumor activities [7,[15][16][17][18] . The current work represents the beginning of collaborative efforts to identify novel natural products that target androgen-independent prostate cancer.…”

“…Liverworts has been shown to produce various types of natural products including terpenoids, phenolic compounds, and cyclic bisbibenzyls [6][7][8][9][10][11][12] . The cyclic bisbibenzyls are particularly interesting because they constitute a class of natural products with unique structural frameworks, and exhibit a diversity of biological activities as indicated by their antimicrobial and antifungal activities [8,9,13,14] , cytotoxicity [6,7,15,16] , induction of apoptosis [17] , reversal of multidrug resistance [18] , and inhibitory effects on 5-lipoxygenase, cyclooxygenase and DNA polymerase [8,19] .…”

Syntheses of Macrocyclic Bis(bibenzyl) Compounds Derived from Perrottetin E

“…The combined organic layers were washed with saturated aqueous NaCl (5 ϫ 50 mL) and dried (MgSO 4 ), and the solvent was evaporated under reduced pressure. [39] The aldehyde 18 (27.2 g, 86.5 mmol) was dissolved in THF (50 mL) and EtOH (250 mL). NaBH 4 (3.28 g, 86.7 mmol) was added at 0°C and the mixture was stirred for 30 min.…”

Synthesis and Electrochemical Properties of Tetrasubstituted Tetraphenylethenes

“…Scheme 3 shows the synthesis of the tetrakis(4-phenoxyphenyl)ethene 1i, which was obtained from 4,4Ј-dihydroxybenzophenone 2b which underwent an Ullmann etherification [27] in the presence of bromobenzene, CuO and K 2 CO 3 in pyridine to give the benzophenone derivative 3a in 29 % yield. Subsequent McMurry coupling under the usual conditions [19] yielded the target ether 1i in 34 %.…”