Total spondylectomy of recurrent giant cell tumors in the cervical spine

Abstract

Rationale:Spinal Giant Cell Tumors (SGCTs) are rare, aggressive, and benign tumors. Their presence in the cervical spine is even more exceptional. There are few reports of cervical GCT in the literature, especially recurrent cases. The treatment are challenging to clinically because radical resection is extremely difficult.Patient concerns:In this study, we present the cases of a 25-year-old man and a 41-year-old woman who suffered from recurrent cervical GCT.Interventions:They underwent extensive total spondylectomy of C3-5 and C2-4, respectively, by a combined anterior and posterior approach.Outcomes:Both patients had a satisfactory prognosis after 2 years followe-up, and extensive total spondylectomy provided good disease-free survival rates. Extensive total spondylectomy of cervical recurrent giant cell tumor was successfully achieved combined anterior and posterior approach.Lessons:This surgical technique can be an effective option for this pathological condition, which is difficult to manage using other conventional treatment options including repeated curettage and radiotherapy. However, there are insufficient data on long-term subjective outcomes in this type of patient, and larger series studies are needed to determine the efficacy of this approach, especially compared with piecemeal resection techniques.

Multimodal Management of Combined Posterior and Anterior Surgical Approach and Postoperative Pharmacological Therapy for Giant Cell Tumor of the Cervical Spine Encasing the Vertebral Artery: A Technical Case Report

“…In general, local radiation, denosumab, or bisphosphonate can be used as adjuvant treatments after partial or subtotal resection of cervical GCT (Table 1). 1,2,[8][9][10][11][12][13] Radiation is administered as an adjuvant treatment to prevent postoperative recurrence in cases in which complete resection is difficult, but its efficacy is still controversial. 14,15) It has also been reported that myelopathy and radiationinduced sarcoma may develop due to radiotherapy.…”

Primary malignancy in giant cell tumor of thoracic vertebrae

“…Giant cell tumor of bone (GCTB) usually appears as a benign tumor with local aggressiveness. [ 1 ] Malignant giant cell tumor of bone (MGCTB) is rare and is currently described as either primary or secondary. Only a few cases have been described in the literature to date.…”

Anterior stabilization of C1–C4 vertebrae after transoral removal of a giant cell tumor of C2–C3 vertebrae

“…Заболеваемость опухолями в подвижном отделе позвоночника (выше крестца) колеблется от 1,4 до 9,4 %, а вовлечение шейного отдела позвоночника происходит еще реже [7]. Несмотря на доброкачественную природу опухоли, локально она может быть агрессивной и иметь метастатический потенциал [8].…”