Total Serum Antioxidant Capacity in Healthy Normal Weight and Asymptomatic Overweight Adults

Abstract

Obesity and overweight are major contributors to the burden of chronic disease. Both are defined as abnormal or excessive fat accumulation and by increased production of free radicals leading to oxidative stress. The aim of the present study was to evaluate whether overweight and fat accumulation is associated with serum total antioxidant capacity (TAC) in men and women, irrespective of nutritional habits, nutrient intakes, physical activity, smoking, and other confounders, which may be responsible for modifying the association between serum TAC and overweight/obesity measures. This cross-sectional study was conducted on 60 normal weight and 60 overweight adults aged 25-49. All participants underwent standard anthromorphological measurements of body composition, blood pressure and biochemical measurements, aerobic capabilities assessment and dietary intake evaluation. TAC was measured by using the photochemioluminescence method. All data were analysed with SPSS software. Men had higher values of TAC than women and concentrations of TAC were significantly higher in overweight subjects compared to normal weight subjects. In the present study TAC tended to be increased by various metabolic risk factors, especially overweight/obesity parameters (body mass index, body fat), inflammation and increased serum levels of Cysteine, irrespective of nutritional habits, nutrient intakes, physical activity and smoking. Overweight and obesity at an early stage may stimulate TAC. Therefore, the elevation of TAC in overweight adults may be a compensatory response to oxidative stress, generated by reactive oxygen species.

Obesity and STING1 genotype associate with 23-valent pneumococcal vaccination efficacy

“…The nonobese individuals were younger than the obese individuals (mean ± SEM, 95% CI: 23.0 ± 0.643, 21.7-24.4 vs. 29.0 ± 1.11, 26.7-31.3; P < 0.001). Participants in the obese group showed significantly elevated BMI, waist/hip ratio, WBC counts, hemoglobin A1C, erythrocyte sedimentation rate, and blood pressure compared with the nonobese group, which aligns with other studies involving obese participants (Table 1) (18)(19)(20). One adverse event occurred due to local swelling at the site of the vaccine injection, which resolved within 2 weeks.…”

Nitric oxide products are not associated with metabolic syndrome

“…Considering the fact that abdominal obesity is the key characteristic of MetS (2), it is assumed that visceral adipose tissue through increased mitochondrial oxidation of free fatty acids represents the main generator of reactive oxygen (ROS) and reactive nitrogen species (RNS) (3). Indeed, previous studies confirmed an increase in some of the oxidative stress biomarkers, as well as a decrease in the antioxidant defence system in individuals with overweight/obesity (4, 5). However, it is questionable whether all of these biomarkers can predict MetS since discrepancies in the literature exist considering the relationship between oxidative stress biomarkers and MetS and/or its components (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16).…”

Relationship between oxygen radical absorbance capacity (ORAC) index, body composition and blood biochemical markers in overweight /obese compared to normal weight subjects: a cross-sectional study

“…As well as, Many studies have supported these ndings [48][49][50]. Some studies have also reported that antioxidant capacity in obese and overweight volunteers is promoted which was postulated to be due to immune system's trying to override the present in ammation [51,52].…”