Nitric oxide products are not associated with metabolic syndrome

Abstract

Summary Background Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS. Methods A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002–1.019; p=0.016), XO (OR=1.014; 95% CI 1.003–1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038–1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005–1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 μmol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusion Unlike XOD, MDA and AOPP, NOx is not associated with MetS.

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

“…Similar results were reported by other authors who found no statistical differences in NO levels in obesity. 48,49 Furthermore, it is described that the capacity of the endothelium to release NO under basal conditions is not compromised in overweight and obese adults. 50 Adipocytes secrete TNF-α and IL-6, and their concentration is associated with the percentage and distribution of adipose tissue in the body.…”

Nitric oxide, lipid peroxidation products, and antioxidants in primary fibromyalgia and correlation with disease severity

“…According to available literature, NO may be involved in the initiation of LPO (34) by many putative ways, NO a donor of S-nitroso-N-acetyl penicillamine (SNAP) in U937 cells can inhibit glutathione peroxidase that leads to increased levels of lipid peroxidation (34). Another way is the reaction of NO with molecular oxygen generates a radical-radical combination of product nitrogen dioxide (•NO 2 ), which can initiate lipid peroxidation (8).…”

“…It has a great capability of diffusion between body tissues and performs several important biological functions such as vasodilatation, modulation of nociception, immune function, neurotransmission, and excitation-contraction coupling (6,7). NO a free radical signal-transuding agent, has been shown to undergo a sequence of reactions, leading to the generation of reactive nitrogen species (RNS) in a variety of cells (8).…”

“…Recent studies have shown the involvement of NO in the initiation of lipid peroxidation, which may have a role in the severity of FMS (8).…”

Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism

“…With this balance, the damage to the organism by the free radicals is prevented. The imbalance between free radical production and the antioxidant defence system for free radicals is called the »oxidative stress« (7,8) Total antioxidant status (TAS) reflects the total effect of all antioxidants, and total oxidant status (TOS) reflects the total effect of all oxidants in plasma and body fluids (7,9,10). Paraoxonase 1 (PON1) is a serum esterase and the most known member of the paraoxonase multigene family (11).…”