Total plasma homocysteine, folate, and vitamin b12 status in healthy Iranian adults: the Tehran homocysteine survey (2003–2004)/a cross – sectional population based study

Fakhrzadeh, Hossein; Ghotbi, Sara; Pourebrahim, Rasoul; Nouri, Masoumeh; Heshmat, Ramin; Bandarian, Fatemeh; Shafaee, A; Larijani, Bagher

doi:10.1186/1471-2458-6-29

Cited by 61 publications

(54 citation statements)

References 47 publications

(72 reference statements)

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“…In our study, the highest frequency of deficiency was observed in We also noted that men had lower levels of vitamin B 12 compared to women. The same result has been noted in other studies [14,18].…”

Section: Discussionsupporting

confidence: 81%

“…This is similar to a previous report from north Jordan on 216 healthy individuals by Fora and Mohammad where a suboptimal (< 222 pg/mL) serum level of B 12 was observed in 48.1% of patients [14], and also similar to reports from Israel by Masalha et al (49%) and Gielchinsky et al (31%) [15,16]. Similar reports of high prevalence in this region came from Turkey (46.8%) [17] and the Islamic Republic of Iran (26.7%) [18]. These are higher than the reported global prevalence, which ranges from 3% to 40% of the adult population [3][4][5][6][7].…”

Section: Discussionsupporting

confidence: 73%

“…These are higher than the reported global prevalence, which ranges from 3% to 40% of the adult population [3][4][5][6][7]. Some evidence suggests that this variation is mainly related to ethnic variations, dietary habits, geographical variation and intestinal malabsorption problems, or to different cut-off values for serum vitamin B 12 level in the definition of deficiency [17,18].…”

Section: Discussionmentioning

confidence: 42%

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High frequency of low serum levels of vitamin B [12] among patients attending Jordan University Hospital

Barghouti¹,

Younes²,

Halaseh³

et al. 2009

East Mediterr Health J

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This study aimed to estimate the status of serum vitamin B 12 level in patients attending Jordan University Hospital in Amman, and to examine the relationship with demographic data, chronic illness, dietary habits, haematological parameters and symptoms related to vitamin B 12 levels. A total of 838 patients completed a questionnaire and gave blood samples; 44.6% were vitamin B 12 deficient (< 180 pg/mL) and 34.2% had hypovitaminosis (180-300 pg/mL). Vitamin B 12 deficiency was associated with memory impairment, low meat intake and strict vegetarian (vegan) diets. The high frequency of low vitamin B 12 warrants the development of a strategy to correct this problem in Jordan. Fréquence élevée de faibles taux de vitamine B 12 sériques chez les patients de l'hôpital universitaire de Jordanie RÉSUMÉ Cette étude visait à estimer les taux de vitamine B12 sériques chez les patients de l'hôpital universitaire de Jordanie à Amman, et à examiner la relation avec les données démographiques, les maladies chroniques, les habitudes alimentaires, les paramètres hématologiques et les symptômes liés à ces taux. Au total, 838 patients ont rempli un questionnaire et ont été soumis à une prise de sang ; 44,6 % présentaient une déficience en vitamine B12 (< 180 pg/mL) et 34,2 % une hypovitaminose (180-300 pg/mL). La déficience en vitamine B12 était associée à des troubles de la mémoire, de faibles apports carnés et un régime végétarien strict (végétalien). La fréquence élevée de faibles taux de vitamine B12 justifie l'élaboration d'une stratégie visant à corriger ce problème en Jordanie.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 42%

See 1 more Smart Citation

High frequency of low serum levels of vitamin B [12] among patients attending Jordan University Hospital

Barghouti¹,

Younes²,

Halaseh³

et al. 2009

East Mediterr Health J

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“…This is consistent with studies of healthy population (Lim and Heo, 2002;Chang et al, 2003;Fakhrzadeh et al, 2006;Taskin et al, 2006). Higher homocysteine concentrations in men than in women may be explained by differences in muscle mass, hormone and vitamin status (Refsum et al, 2006).…”

Section: Conventional Cardiovascular Risk Factorssupporting

confidence: 90%

Total cardiovascular risk profile of Taiwanese vegetarians

Chen

Lin

et al. 2007

Eur J Clin Nutr

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Background: Although the health benefits of vegetarian diets have been well documented among Western population, there are geographic differences of vegetarian diets and the health benefits of the Taiwanese vegetarian diet have not been studied extensively. In addition to conventional risk factors, homocysteine and high-sensitivity C-reactive protein (hs-CRP) levels have been found to predict first atherothrombotic events. We undertook this study to examine the total risk profile of Taiwanese vegetarians. Methods: A total of 198 healthy subjects (99 vegetarians and 99 omnivores) were recruited. Fasting blood samples were analyzed for glucose, cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), white blood cell count, hs-CRP and homocysteine. Results: There was no significant difference in age, body mass index, blood glucose, white blood cell count, triglyceride and HDL-C between the two groups. The vegetarian group had significantly more females (65.7 vs 46.5%); lower body weight (58.66711.13 vs 62.88712.24 kg); shorter height (159.1477.88 vs 162.53 78.14 cm); lower total cholesterol (184.74733.23 vs 202.01741.05 mg/dl); and lower LDL-C (119.63731.59 vs 135.89739.50 mg/dl). Hs-CRP was significantly lower (0.1470.23 vs 0.2370.44 mg/dl, P ¼ 0.025), whereas homocysteine was significantly higher (10.9776.69 vs 8.4472.50 mmol/l, P ¼ 0.001) in vegetarians than omnivores. Conclusions: Taiwanese vegetarians have lower total cholesterol, LDL-C and hs-CRP levels, and higher homocysteine levels than omnivores. Owing to different predictive value of each risk factor, the Taiwanese vegetarians had a better cardiovascular risk profile than omnivores. Whether the Taiwanese vegetarian diet should be supplemented with vitamin B 12 to lower serum homocysteine level remains to be addressed.

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“…As shown in Table 3 and 4, out of the 7 samples that showed low holoTC levels, 6 showed normal serum vitamin B12 levels, and the serum vitamin B12 levels in 4 of Further, folate and vitamin B12 act as cosubstrate and cofactor, respectively in Hcy metabolism [20]. As shown in Table 4, elevated serum Hcy levels have been linked to both vitamin B12 and folate deficiency [10,21,22].…”

mentioning

confidence: 99%

Relationship between the Levels of Holotranscobalamin and Vitamin B12

et al. 2010

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Vitamin B12 is essential for cellular metabolism, particularly DNA synthesis and regulation. Vitamin B12 deficiency may cause severe and irreversible damage, and early detection of vitamin B12 deficiency is important. While vitamin B12 status is currently determined by performing blood tests to assess serum vitamin B12 levels, the diagnostic accuracy of these tests is low [1,2].To obtain a more sensitive marker of vitamin B12 status, a new test involving measurement of the levels of holotranscobalamin (holoTC)-transcobalamin-vitamin B12 complex-has been introduced [3][4][5][6][7]. HoloTC promotes global cellular uptake of cobalamin by specific receptors; therefore, it may be more sensitive than serum vitamin B12 levels in indicating vitamin B12 status [8]. We investigated the association between the levels of holoTC and serum vitamin B12, determined the diagnostic value of holoTC levels in populations susceptible to vitamin B12 deficiency, and performed a precision test for the AxSYM holoTC assay.We included 45 samples from patients for whom a serum 185To date, the determination of serum vitamin B12 levels has been the most common laboratory test for the assessment of vitamin B12 status; however, the diagnostic accuracy of this test is low. To obtain a more sensitive marker, a new test to measure holotranscobalamin (holoTC) levels has been introduced. In this study, we assessed 45 patients for whom a vitamin B12 test had been requested and 139 anemic patients. We investigated the associations between the levels of homocysteine (Hcy) and those of holoTC, serum vitamin B12, and folate and assessed the diagnostic value of holoTC levels as a marker for vitamin B12 deficiency. We also determined the precision of the AxSYM holoTC assay by calculating the coefficient of variance (CV). The within-run and betweenrun precision values were excellent, as all CV values were less than 3.5%. The holoTC levels were low (<35 pmol/L) in 7 samples, and 6 of these samples had normal total serum vitamin B12 levels. In 2 of these samples, high Hcy levels (>12 mmol/L) indicated vitamin B12 deficiency. Thus, the holoTC levels were more sensitive than the serum vitamin B12 levels for indicating vitamin B12 status. If the serum vitamin B12 level is 151-300 pmol/L, the levels of holoTC alone or in combination with serum vitamin B12 levels are likely to be more useful markers than serum vitamin B12 levels alone. (Korean J Lab Med 2010;30:185-9)

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Total plasma homocysteine, folate, and vitamin b12 status in healthy Iranian adults: the Tehran homocysteine survey (2003–2004)/a cross – sectional population based study

Cited by 61 publications

References 47 publications

High frequency of low serum levels of vitamin B [12] among patients attending Jordan University Hospital

High frequency of low serum levels of vitamin B [12] among patients attending Jordan University Hospital

Total cardiovascular risk profile of Taiwanese vegetarians

Relationship between the Levels of Holotranscobalamin and Vitamin B12

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