Total plasma antioxidant capacity in cystic fibrosis

Lands, Larry C.; Grey, Vijaylaxmi; Grenier, C.

doi:10.1002/(sici)1099-0496(200002)29:2<81::aid-ppul1>3.0.co;2-n

Cited by 29 publications

(13 citation statements)

References 28 publications

(31 reference statements)

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“…Although statistically significant, the correlations obtained were relatively small and considered related to a complex, non-linear interaction between various components while studies on groups of human patients with particular disease i. e. cystic fibrosis show different pattern of interrelation like significant correlation with uric acis but not with albumin, vitamin A or E or lymphocyte glutathione concentration (Lands et al 2000). In experimentally induced diabetes in rats TAC significantly correlated with plasma albumin levels (F eillet-Coudray et al 1999) or direct, highly significant correlation of TAC and bilirubin was found in neonatal plasma (Gopinathan et al 1994).…”

Section: Discussionmentioning

confidence: 87%

“…Several human studies investigated a correlation between TAC and different individual antioxidants, i. e. uric acid as major antioxidant in humans, albumin, vitamin A and E and bilirubin (Cao and Prior 1998;Chapple 1997;Dailly et al 998; L a n d s et al 2000;Moore et al 1994). As no data could be obtained about the correlation between TAC and specific individual antioxidants in dogs, our study also focused on interrelation between TAC and albumin, total bilirubin, vitamin A and E, β-carotene and Vit E(LS).…”

Section: Discussionmentioning

confidence: 99%

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Total Antioxidant Capacity (TAC) Values and Their Correlation with Individual Antioxidants in Healthy Beagles

Nemec¹,

Drobnič‐Košorok²,

Skitek³

et al. 2000

Acta Vet. Brno

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The paper aims to establish a range for serum Total Antioxidant Capacity (TAC) and to determine the correlation between TAC and some individual antioxidants (vitamin A and E, lipid standardised vitamin E [Vit E/LS/], β-carotene, total bilirubin and albumin) in a uniform population of beagle dogs. Emphasis was directed on their general health status to establish a basis for future investigation of the role of TAC in diseases of dogs as species most frequently studied in veterinary medicine. The animal body possesses a variety of protective antioxidant substances that act as a harmoniously and finely tuned mechanism to neutralise harmful oxidants. TAC measurements provide a tool for establishing links between antioxidant capacity and the risk of disease as well as for monitoring of antioxidant therapy. Serum samples of 19 healthy beagles were assayed for TAC on LP 700 photometer (Dr. Lange, Germany) with a commercially available TAS kit ("Total Antioxidant Status" -TAS; Randox, Crumlin, UK). TAS kit measures the capacity of all of the antioxidants present in serum or plasma sample. The assay is based on the suppression of the absorbance of the radical cation of 2,2"-azinobis (3-ethylbenzothiazoline-6-sulfonate) (ABTS •+ ) by antioxidants. Assay results are expressed as mmol/l of Trolox (6-hydroxy-2, 5, 7, -tetramethylchroman-2-carboxylic acid -a water-soluble analogue of α-tocopherol) equivalents. The range for TAC expressed as mean ± SD resulted in 1.08 ± 0.08 mmol/l. TAC correlated positively with albumin (r = 0.18), vitamin E (r=0.14) and Vit E (LS) (r = 0.20), and negatively with total bilirubin (r = -0.30), vitamin A (r = -0.15) and β-carotene (r = -0.13) although no significant correaltion has been found.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Total Antioxidant Capacity (TAC) Values and Their Correlation with Individual Antioxidants in Healthy Beagles

Nemec¹,

Drobnič‐Košorok²,

Skitek³

et al. 2000

Acta Vet. Brno

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“…During active infection neutrophils and macrophages generate reactive oxygen species (ROS), which are necessary for bacterial killing, but may be harmful when tissue antioxidant capacity is exceeded [3]. Despite routine supplementation with fat soluble vitamins, such as the antioxidants vitamin E and carotenoids, biochemical markers for a disturbed oxidantantioxidant balance remain present in many CF patients [4][5][6][7]. Therefore, several studies concerning micronutrient supplements have been performed in CF patients, using various amounts of α-tocopherol, retinol, ascorbic acid, and carotenoids.…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation with multiple micronutrients: No beneficial effects in pediatric cystic fibrosis patients

Oudshoorn

Klijn²,

Hofman³

et al. 2007

Journal of Cystic Fibrosis

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“…There has been renewed interest in antioxidants in CF following various observational studies that reported an association of low levels of antioxidants, increased OxS markers, and impaired clinical condition in patients (8,62,90,157,159). Their incorporation into patient management protocols in the form of routine supplementation has therefore been widespread.…”

Section: Antioxidantsmentioning

confidence: 99%

“…Their incorporation into patient management protocols in the form of routine supplementation has therefore been widespread. However, certain studies aimed at evaluating the effects of this type of supplementation in CF patients have revealed generally low levels of antioxidants (CoQ 10, a-tocopherol, vitamin A, GSH) (8,62,77,90,119,159), more or less casting doubt on their efficacy. This was the motivation for various intervention studies aimed at supplementing patients over a determined period and evaluating the impact on their antioxidant profile.…”

Section: Antioxidantsmentioning

confidence: 99%

Cystic Fibrosis-Related Oxidative Stress and Intestinal Lipid Disorders

Kleme

Lévy²

2015

Antioxidants & Redox Signaling

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Significance: Cystic fibrosis (CF) is the most common lethal genetic disorder in the Caucasian people. It is due to the mutation of cystic fibrosis transmembrane conductance regulator (CFTR) gene located on the long arm of the chromosome 7, which encodes for CFTR protein. The latter, an adenosine triphosphate binding cassette, is a transmembrane chloride channel that is also involved in glutathione transport. As glutathione/glutathione disulfide constitutes the most important pool of cellular redox systems, CFTR defects could thus disrupt the intracellular redox balance. Resulting multisystemic diseases are essentially characterized by a chronic respiratory failure, a pancreatic insufficiency, an essential fatty acid deficiency (EFAD), and inadequate levels of antioxidant vitamins. Recent Advances: The pathophysiology of CF is complex; however, several mechanisms are proposed, including oxidative stress (OxS) whose implication is recognized and has been clearly demonstrated in CF airways. Critical Issues: Little is known about OxS intrinsic triggers and its own involvement in intestinal lipid disorders. Despite the regular administration of pancreatic supplements, high-fat high-calorie diets, and antioxidant fat-soluble vitamins, there is a persistence of steatorrhea, EFAD, and harmful OxS. Intriguingly, several trials with elevated doses of antioxidant vitamins have not yielded significant improvements. Future Directions: The main sources and self-maintenance of OxS in CF should be clarified to improve treatment of patients. Therefore, this review will discuss the potential sources and study the mechanisms of OxS in the intestine, known to develop various complications, and its involvement in intestinal lipid disorders in CF patients. Antioxid. Redox Signal. 22, 614-631.

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Total plasma antioxidant capacity in cystic fibrosis

Cited by 29 publications

References 28 publications

Total Antioxidant Capacity (TAC) Values and Their Correlation with Individual Antioxidants in Healthy Beagles

Total Antioxidant Capacity (TAC) Values and Their Correlation with Individual Antioxidants in Healthy Beagles

Dietary supplementation with multiple micronutrients: No beneficial effects in pediatric cystic fibrosis patients

Cystic Fibrosis-Related Oxidative Stress and Intestinal Lipid Disorders

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