Dietary supplementation with multiple micronutrients: No beneficial effects in pediatric cystic fibrosis patients

Oudshoorn, Johanna H.; Klijn, Peter; Hofman, Zandrie; Voorbij, H. A. M.; Ent, Cors K. van der; Berger, Ruud; Houwen, Roderick H. J.

doi:10.1016/j.jcf.2006.05.005

Cited by 25 publications

(7 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are comparable to those seen in previous trials that have examined supplementation with β-carotene and/or other antioxidant formulations in CF [4,[21][22][23][24][25][26][27]. The results of several of these studies have been previously reviewed [28].…”

Section: Parametersupporting

confidence: 83%

Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis

Sagel

Sontag

Anthony

et al. 2011

Journal of Cystic Fibrosis

View full text Add to dashboard Cite

show abstract

Section: Parametersupporting

confidence: 83%

Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis

Sagel

Sontag

Anthony

et al. 2011

Journal of Cystic Fibrosis

View full text Add to dashboard Cite

show abstract

“…Clinical trials directed toward enhancing lung antioxidants using NAC and other direct antioxidant molecules, such as vitamin E, showed modest or no effect on FEV 1 decline (49)(50)(51). This failure may be attributed to the fact that a single antioxidant molecule may not be efficacious in affording protection against the plethora of oxidants present in cigarette smoke.…”

Section: Discussionmentioning

confidence: 99%

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

Malhotra¹,

Thimmulappa²,

Navas‐Acien³

et al. 2008

Am J Respir Crit Care Med

340

307

View full text Add to dashboard Cite

show abstract

“…Also each participant appears in both the treatment and control group, so the two groups are not independent. In order to combine these results with the data entered from already included parallel studies, the authors will use the methods recommended by Curtin (Curtin 2002a; Curtin 2002b; Curtin 2002c). …”

Section: Methodsmentioning

confidence: 99%

Oral protein calorie supplementation for children with chronic disease

Smith

Saljuqi²,

Watling

2015

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Background Poor growth and nutritional status are common in children with chronic diseases. Oral protein calorie supplements are used to improve nutritional status in these children. These expensive products may be associated with some adverse effects, e.g. the development of inappropriate eating behaviour patterns. This is a new update of a Cochrane review last updated in 2009. Objectives To examine evidence that in children with chronic disease, oral protein calorie supplements alter daily nutrient intake, nutritional indices, survival and quality of life and are associated with adverse effects, e.g. diarrhoea, vomiting, reduced appetite, glucose intolerance, bloating and eating behaviour problems. Search methods Trials of oral protein calorie supplements in children with chronic diseases were identified through comprehensive electronic database searches, handsearching relevant journals and abstract books of conference proceedings. Companies marketing these products were also contacted. Most recent search of the Group's Trials Register: 24 February 2015. Selection criteria Randomised or quasi‐randomised controlled trials comparing oral protein calorie supplements for at least one month to increase calorie intake with existing conventional therapy (including advice on improving nutritional intake from food or no specific intervention) in children with chronic disease. Data collection and analysis We independently assessed the outcomes: indices of nutrition and growth; anthropometric measures of body composition; calorie and nutrient intake (total from oral protein calorie supplements and food); eating behaviour; compliance; quality of life; specific adverse effects; disease severity scores; and mortality; we also assessed the risk of bias in the included trials. Main results Four studies (187 children) met the inclusion criteria. Three studies were carried out in children with cystic fibrosis and one study included children with paediatric malignant disease. Overall there was a low risk of bias for blinding and incomplete outcome data.Two studies had a high risk of bias for allocation concealment. Few statistical differences were found in the outcomes we assessed between treatment and control groups, except change in total energy intake at six and 12 months, mean difference 304.86 kcal per day (95% confidence interval 5.62 to 604.10) and mean difference 265.70 kcal per day (95% confidence interval 42.94 to 485.46), respectively. However, these were based on the analysis of just 58 children in only one study. Only two chronic diseases were included in these analyses, cystic fibrosis and paediatric malignant disease. No other studies were identified which assessed the effectiveness of oral protein calorie supplements in children with other chronic diseases. Authors' conclusions Oral protein calor...

show abstract

Dietary supplementation with multiple micronutrients: No beneficial effects in pediatric cystic fibrosis patients

Abstract: The micronutrient mixture was not superior to placebo with respect to changes in pulmonary function or muscle performance in pediatric CF patients, despite a significant increase in plasma vitamin E concentrations.

Cited by 25 publications

References 39 publications

Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis

Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

Oral protein calorie supplementation for children with chronic disease

Contact Info

Product

Resources

About