Total Phenolic Content, Anti-inflammatory, Analgesic, and Antipyretic Activities of Some Extracts ofInula viscosa(L.) from Algeria

Abstract

Inula viscosa (L.) is a medicinal plant that has been used for a long time for its many therapeutic properties, especially to treat pain and inflammation. The aim of this study was to evaluate the anti-inflammatory, analgesic, and antipyretic activities of methanolic extracts and decoctions of Inula viscosa leaves and flowers. The phenol content of the extracts was determined by spectrophotometric methods. The extracts were administered orally (400, 600, and 800 mg/kg) to mice and/or rats in the study of antiinflammatory (carrageenan-induced paw edema test), analgesic (acetic acid-induced writhes test), and antipyretic (Brewer’s yeast-induced pyrexia method) activities. The highest phenolic content was found in leaf methanolic extract. Methanolic extracts and decoctions of leaves and flowers showed significant decrease in mice paw edema after 4 h (P < 0.01; P < 0.001), and an appreciable analgesic effect at the tested doses with a maximum of writhing inhibition observed with leaf methanolic extract at the dose of 800 mg/kg (93.39%; P < 0.001). The rectal temperature of the rats decreased significantly (P < 0.01; P < 0.001) after 4 h in groups treated with leaves and flowers extracts at the doses of 600 and 800 mg/kg. The obtained results confirm the traditional uses of Inula viscosa.

Ointment-Based Combination of Dittrichia viscosa L. and Marrubium vulgare L. Accelerate Burn Wound Healing

“…In the study of Ouahchia et al [ 36 ], D. viscosa was reported to possess analgesic activity with 93.39% of writhing inhibition at a dose of 800 mg/kg. Additionally, in another study conducted by Martin et al [ 37 ], D. viscosa proved its analgesic activity.…”

A comprehensive review on ethnomedicinal uses, phytochemistry, toxicology, and pharmacological activities of Dittrichia viscosa (L.) Greuter

“…The maximum inhibition for writhing was observed with a dose of 800 mg/kg of the ethanolic extract obtained from leaves (93.39%). 92 The conclusions of the last studies are backed by the findings of Side Larbi et al (2016) who investigated the effect of both the methanol extract and essential oil on central analgesia in rats. The study revealed that both samples had a significant central analgesia by increasing the latency time in the tail immersion test, with a clear dose-dependent relationship in the induced analgesic effect.…”

Phytochemical Properties of Crataegus azarolus Berries Decoction Extract and Evaluation of its Protective Activity Against Acetic Acid-Induced Ulcerative Colitis in Rats

“…However, the cytoprotection provided by CAB-DE is in part correlated to its richness in phenolic compounds which are also known for their antioxidant and anti-inflammatory properties. 54,55 Moreover, tannins have several physiological activities such as blocking the inflammatory mediator synthesis, like prostaglandins and leukotrienes. 56 The study of Pierre et al 57 has shown that condensed tannins provide the protection and integrity of intestinal physiology; they stimulate mucus secretion by goblet cells, minimize inflammatory reaction, and preserve intestinal profile.…”