Total phenolic content and antioxidant and anticholinesterase activities of medicinal plants from the State’s Cocó Park (Fortaleza-CE, Brazil)

Abstract

The State’s Cocó Park in the city of Fortaleza-CE present mainly a mangrove flora and include landscape and medicinal plants. The aim of this study is determining the total phenol content, antioxidant activity against the free radical DPPH and the inhibition of the enzyme acetylcholinesterase (AChE) in ethanolic extracts of 30 medicinal plants and thus assess which plants have potential against Alzheimer's Disease. The plants rich in phenolic compounds with amounts ranging from 297.46 ± 26.94 to 599.30 ± 17.08 mg GAE/g plant extract, which showed greater antioxidant activities (with IC50 against DPPH radical from 3.44 ± 0.16 to 3.73 ± 0.12 µg mL-1) and higher acetylcholinesterase inhibiting power (IC50 < 20 μg mL-1) were Anacardium occidentale, Ceiba pentandraLaguncularia racemosa, Mangifera indica, Myracrodrum urundeuva and Terminalia catappa. Then, these species and their constituents are recommended for more specific studies related to Alzheimer´s Disease.

Chemical Characterization, Phenolic Compounds Quantification, and Assessment of Antioxidant and Anti‐Acetylcholinesterase Activities of Byrsonima sericea DC fruits

“…The authors found that extracts with the high content of total phenols had the highest antioxidant activity. [27] The antioxidant capacity of the extracts was quantified in terms of the median inhibitory concentration of the free radicals DPPH * and ABTS + * (IC 50 ). These methods have been widely used to determine the antioxidant action of plant products due to their easy execution, low cost, high sensitivity and speed.…”

“…The most common compounds are phenolic acids, flavonoids, carotenoids, and vitamins C and E. A study carried out with medicinal plants from Cocó State Park in the city of Fortaleza, Ceará, Brazil, indicated that species with high antioxidant capacity also had in vitro anticholinesterase activity. [27] The anticholinesterase capacity of the extracts was quantified as the median inhibitory concentration of the AChE enzyme and the results obtained were compared to those of the alkaloids physostigmine (the first natural inhibitor discovered) and galantamine (among the natural alkaloids most used as a standard drug against AD). [30] In the anti-AChE test, the samples had IC 50 values ranging from 6.02 to 10.92 μg mL À 1 , and PEE presented the best result.…”

CG-MS, Radical Scavenging, Acetylcholinesterase Inhibition, Antifungal and Molecular Docking Studies of Essential Oil from the Leaves of Tapirira guianensis Aubl

“…Plants with high levels of phenolic compounds such as Anacardium occidentale, Ceiba pentandra, Laguncularia racemosa, Mangifera indica, Myracrodrum urundeuva and Terminalia catappa showed excellent antioxidant activity against the DPPH radical (with IC50 ranging from 3.44 ± 0.16 to 3.73 ± 0.12 µg mL -1 ) and high power of inhibition of the AChE enzyme (IC50< 20 μg mL -1 ) were recommended for more specific studies related to Alzheimer's disease [8].…”

Potencial da planta Psidium guajava L. contra a doença de Alzheimer pela reversão do déficit de memória induzido por escopolamina

“…Uma abordagem promissora no tratamento da doença de Alzheimer (DA) é o uso de produtos naturais que, ao inibir a enzima aceticolinesterase, aumentam níveis de acetilcolina e, consequentemente, revertem o déficit de memória, por tanto, medicamentos que têm a inibição da AChE como mecanismo de ação são chamados de anticolinesterase ou indiretamente colinérgicos (Morais de et al, 2021;Barbosa et al, 2006). Portanto, plantas que tenham de atividades acetilcolinesterásica, anti-inflamatória e antioxidante são potenciais fontes de tratamento para DA.…”