Total phenolic and flavonoid content and antibacterial activity of Punica granatum L. var. pleniflora flowers (Golnar) against bacterial strains causing foodborne diseases

Mahboubi, Arash; Asgarpanah, Jinous; Sadaghiyani, Parisa Nosrati; Faizi, Mehrdad

doi:10.1186/s12906-015-0887-x

Cited by 92 publications

(63 citation statements)

References 28 publications

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“…The content of the phenolic compounds (PC) in PPE was determined by the Folin–Ciocalteu colorimetric method [13] using gallic acid as standard (10–100 μg/mL concentration range). The amounts of PC were assayed in triplicate and expressed as mg of gallic acid in 100 g of PPE.…”

Section: Methodsmentioning

confidence: 99%

Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice

et al. 2016

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Alzheimer’s disease is a chronic and degenerative condition that had no treatment until recently. The current therapeutic strategies reduce progression of the disease but are expensive and commonly cause side effects that are uncomfortable for treated patients. Functional foods to prevent and/or treat many conditions, including neurodegenerative diseases, represent a promising field of study currently gaining attention. To this end, here we demonstrate the effects of pomegranate (Punica granatum) peel extract (PPE) regarding spatial memory, biomarkers of neuroplasticity, oxidative stress and inflammation in a mouse model of neurodegeneration. Male C57Bl/6 mice were chronically infused for 35 days with amyloid-β peptide 1–42 (Aβ) or vehicle (control) using mini-osmotic pumps. Another group, also infused with Aβ, was treated with PPE (p.o.– βA+PPE, 800 mg/kg/day). Spatial memory was evaluated in the Barnes maze. Animals treated with PPE and in the control group exhibited a reduction in failure to find the escape box, a finding that was not observed in the Aβ group. The consumption of PPE reduced amyloid plaque density, increased the expression of neurotrophin BDNF and reduced the activity of acetylcholinesterase enzyme. A reduction in lipid peroxidation and in the concentration of the pro-inflammatory cytokine TNF-α was also observed in the PPE group. No hepatic lesions were observed in animals treated with PPE. In conclusion, administration of pomegranate peel extract has neuroprotective effects involving multiple mechanisms to prevent establishment and progression of the neurodegenerative process induced by infusion with amyloid-β peptide in mice.

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Section: Methodsmentioning

confidence: 99%

Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice

et al. 2016

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“…137 Golnar extract has played a successful role in preventing food poisoning as it exhibited antibacterial action against both gram positive and gram negative food poisoning causing bacterias. 138…”

Section: Anti-bacterialmentioning

confidence: 99%

Chemistry and Pharmacology of Flavonoids- A Review

Rana¹,

Gulliya²

2019

IJPER

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“…Flavonoids also have antiseptic properties, forming complex compounds with different cells in the bacterial cell wall or extracellular protein, which can disrupt bacterial growth. 24 The antimicrobial effects of P. granatum on pathogenic bacteria render it an effective and natural alternative antibacterial treatment; however, further investigation incorporating several bacterial groups is required to ascertain the relationship between antimicrobial activity and polyphenolic substances. The identification of the antimicrobial agents in P. granatum extract has yielded valuable information.…”

Section: Discussionmentioning

confidence: 99%

In vitro Antibiofilm Activity of Pomegranate (Punica granatum) Juice on Oral Pathogens

Pramadita

Widyarman

2019

JIDA

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Introduction: Pomegranate (Punica granatum) fruit contains valuable ingredients, such as ellagitannins and flavonoids, that have many potential effects, including antibacterial, antifungal, and anti-inflammatory functions. Objectives: The aim of this study was to investigate the effects of pomegranate fruit juice on F. nucleatum and S. sanguinis monospecies and multispecies biofilm formation in vitro. Methods: Pomegranate juice was obtained using a juicer and diluted using a brain heart infusion (BHI) broth into five different concentrations. The biofilm assay was performed as follows: F. nucleatum and S. sanguinis were cultured separately in the BHI broth for 48 hours at 37°C in an anaerobic atmosphere. A 200 L bacterial suspension (10 7 CFU/mL) was distributed into a 96-well plate and incubated for 24 hours to form a biofilm. Subsequently, pomegranate juice was added to the biofilm well and observed after 1 hours, 3 hours, 6 hours, and 24 hours. The biofilm mass was measured using a microplate reader (490 nm) after crystal violet staining. Chlorhexidine (0.2%) and the biofilms without treatment were used as the positive and negative controls, respectively. The data were statistically analyzed using one-way analysis of variance, with p<0.05 as the level of significance. Result: There was a significant biofilm reduction after treatment with pomegranate juice for all the concentrations and incubation times (p<0.05). The effective concentrations to inhibit the biofilm monospecies F. nucleatum and S. sanguinis and the multispecies were 6.25% (OD 0.148±0.019), 50% (OD 0.211±0.026), and 6.25% (OD 0.024±0.209), respectively. Conclusion: Pomegranate juice inhibits F. nucleatum and S. sanguinis biofilm formation as a monospecies and a multispecies. Future studies are needed to observe the mechanism of this active substance.

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Total phenolic and flavonoid content and antibacterial activity of Punica granatum L. var. pleniflora flowers (Golnar) against bacterial strains causing foodborne diseases

Cited by 92 publications

References 28 publications

Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice

Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice

Chemistry and Pharmacology of Flavonoids- A Review

In vitro Antibiofilm Activity of Pomegranate (Punica granatum) Juice on Oral Pathogens

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