Chemistry and Pharmacology of Flavonoids- A Review

Rana, Avtar Chand; Gulliya, Bhawna

doi:10.5530/ijper.53.1.3

Cited by 59 publications

(20 citation statements)

References 145 publications

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“…Processes 2020, 8, x FOR PEER REVIEW 2 of 29 existing chemotherapeutics [10]. Because of their positive effects on human and animal health and medical application for disease therapy and chemoprevention, interest in flavonoids is increasing [1,3,4]. Furthermore, they are used in the food and cosmetic industries as pigments and biopreservatives [8].…”

Section: Flavonoids-classification and Natural Sourcesmentioning

confidence: 99%

“…Flavonoids are small molecules, produced de novo by plants as secondary metabolites in response to diverse biotic and abiotic factors. These chemical compounds have a broad spectrum of established health-promoting effects [1][2][3][4]. They are due to their antioxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme functions.…”

Section: Introductionmentioning

confidence: 99%

“…A lot of research teams compared classical modern methods for the extraction of flavonoids from plant materials and discussed their advantages and disadvantages [4,[11][12][13][14][15][16]. But the focus was not on the selectivity of the reviewed methods.…”

Section: Introductionmentioning

confidence: 99%

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Selectivity of Current Extraction Techniques for Flavonoids from Plant Materials

et al. 2020

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Flavonoids have a broad spectrum of established positive effects on human and animal health. They find an application in medicine for disease therapy and chemoprevention, whence the interest in flavonoids increases. In addition, they are used in food and cosmetic industries as pigments and biopreservatives. Plants are an inexhaustible source of flavonoids. The most important step of plant raw material processing is extraction and isolation of target compounds. The quality of an extract and efficiency of a procedure are influenced by several factors: Plant material and pre-extracting sample preparation, type of solvent, extraction technique, physicochemical conditions, etc. The present overview discusses the common problems and key challenges of the extraction procedures and the different mechanisms for selective extraction of flavonoids from different plant sources. In summary, there is no universal extraction method and each optimized procedure is individual for the respective plants. For an extraction technique to be selective, it must combine an optimal solvent or mixture of solvents with an appropriate technique. Last but not least, its optimization is important for a variety of applications. Moreover, when the selected method needs to be standardized, it must achieve acceptable degree of repeatability and reproducibility.

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Section: Flavonoids-classification and Natural Sourcesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Selectivity of Current Extraction Techniques for Flavonoids from Plant Materials

et al. 2020

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“…Extensive biological studies of flavonoids have revealed their health benefits including disease prevention [5,72]. They have exhibited anti-oxidant, anti-inflammatory, antibacterial, and anti-viral activities [73], anti-oxidant [74], anti-allergic anti-carcinogenic properties [75].…”

Section: Health Benefits Of Flavonoidsmentioning

confidence: 99%

Flavonoids: isolation, characterization, and health benefits

Ekalu¹,

Habila

2020

Beni-Suef Univ J Basic Appl Sci

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Background The unique and vast pharmacological activities of flavonoids have made them of research interest. This led to the use of various techniques to isolate and characterize them, intending to determine their potential health benefits. Main text The medicinal values of plant-based flavonoids that this literature review tends to summarize the pharmacological activities of these secondary metabolites from 22 selected plant families. The pharmacological shreds of evidence reported in the literature have proven that flavonoids have shown anti-cancer, anti-microbial, anti-oxidant, anti-inflammatory, anti-fungal, anti-ulcer, and anti-edematogenic activities. Out of these, 30% showed to have anti-oxidant activity, key in protecting the body against free radicals. Besides, 18% of the references showed anti-microbial and anti-cancer activities. Further literature reports indicated that flavonoids from these families exhibited anti-inflammatory and anti-edematogenic (9%), anti-viral and anti-ulcer (5%), anti-fungal, anti-nociceptive, and anti-histamine (2%). Conclusion The pharmacological activities of flavonoids from the various sources reviewed in this study show that the secondary metabolites could provide a scaffold for the development of potent anti-cancer drugs in the future.

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“…However, the quantitative structure-activity relationship (QSAR) for flavonoids as antibacterial agents has been capturing interest through the quantitative construction of associations between the molecular structures or properties with a variation in biological activities [18,33]. It is significant that anticancer activity, which is comprised of the most interesting pharmacological properties of flavonoids [34], proceeds via a unique mechanism, and aids in the prevention of cancer growth through the flavonoids' ability to function as anti-oxidants [35][36][37], enzyme inhibitors [38], and growth regulators [39]. Moreover, the biological performance of flavonoid molecules is reliant on their position and number of substitutions as well as their structures' condensation level, namely glucosides, homodimers, heterodimers, hydroxy groups, and isoprenyl units [40,41].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Biological Assessment, and Structure Activity Relationship Studies of New Flavanones Embodying Chromene Moieties

et al. 2020

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Novel flavanones that incorporate chromene motifs are synthesized via a one-step multicomponent reaction. The structures of the new chromenes are elucidated by using IR, 1H-NMR, 13C-NMR, 1H-1H COSY, HSQC, HMBC, and elemental analysis. The new compounds are screened for their in vitro antimicrobial and cytotoxic activities. The antimicrobial properties are investigated and established against seven human pathogens, employing the agar well diffusion method and the minimum inhibitory concentrations. A majority of the assessed derivatives are found to exhibit significant antimicrobial activities against most bacterial strains, in comparison to standard reference drugs. Moreover, their cytotoxicity is appraised against four different human carcinoma cell lines: human colon carcinoma (HCT-116), human hepatocellular carcinoma (HepG-2), human breast adenocarcinoma (MCF-7), and adenocarcinoma human alveolar basal epithelial cell (A-549). All the desired compounds are subjected to in-silico studies, forecasting their drug likeness, bioactivity, and the absorption, distribution, metabolism, and excretion (ADME) properties prior to their synthetic assembly. The in-silico molecular docking evaluation of all the targeted derivatives is undertaken on gyrase B and the cyclin-dependent kinase. The in-silico predicted outcomes were endorsed by the in vitro studies.

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Chemistry and Pharmacology of Flavonoids- A Review

Cited by 59 publications

References 145 publications

Selectivity of Current Extraction Techniques for Flavonoids from Plant Materials

Selectivity of Current Extraction Techniques for Flavonoids from Plant Materials

Flavonoids: isolation, characterization, and health benefits

Synthesis, Biological Assessment, and Structure Activity Relationship Studies of New Flavanones Embodying Chromene Moieties

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