Total Oxidant Scavenging Capacity of <i>Euterpe oleracea </i>Mart. (Açaí) Seeds and Identification of Their Polyphenolic Compounds

Rodrigues, Roberta K.; Lichtenthäler, Ramona; Zimmermann, Benno F.; Papagiannopoulos, Menelaos; Fabricius, Heinz; Marx, Friedhelm; Maia, José Guilherme S.; Almeida, Ossalin de

doi:10.1021/jf058169p

Cited by 128 publications

(94 citation statements)

References 23 publications

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“…It has been reported by Matthan et al that impaired cholesterol homeostasis, reflected by increased cholesterol absorption and low synthesis markers, is the profile associated with prevasis that consumption of Euterpe oleracea can attenuate atherosclerosis. In addition to the previously reported possible antiatherosclerotic properties of Euterpe oleracea, mainly based on the high content of antioxidant compounds in their fruits [14][15][16] , our study has shown that consumption of Euterpe oleracea extract improved of Euterpe oleracea, which has these two constituents, may be associated with a lower rate of cholesterol absorption by the small intestine.…”

Section: Histopathology and Immunohistochemistrysupporting

confidence: 63%

Euterpe Oleracea (Açai) Modifies Sterol Metabolism and Attenuates Experimentally-Induced Atherosclerosis

Feio

Izar

Ihara

et al. 2012

JAT

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Aim: Euterpe oleracea (açai) is a fruit from the Amazon region whose chemical composition may be beneficial for individuals with atherosclerosis. We hypothesized that consumption of Euterpe oleracea would reduce atherosclerosis development by decreasing cholesterol absorption and synthesis. Methods: Male New Zealand rabbits were fed a cholesterol-enriched diet (0.5%) for 12 weeks, when they were randomized to receive Euterpe oleracea extract (n = 15) or water (n = 12) plus a 0.05% cholesterol-enriched diet for an additional 12 weeks. Plasma phytosterols and desmosterol were determined by ultra-performance liquid chromatography and mass spectrometry. Atherosclerotic lesions were estimated by computerized planimetry and histomorphometry. Results: At sacrifice, animals treated with Euterpe oleracea had lower levels of total cholesterol (p=0.03), non-HDL-cholesterol (p = 0.03) and triglycerides (p = 0.02) than controls. These animals had smaller atherosclerotic plaque area in their aortas (p= 0.001) and a smaller intima/media ratio (p=0.002) than controls, without differences in plaque composition. At the end of the study, campesterol, β-sitosterol, and desmosterol plasma levels did not differ between groups; however, animals treated with Euterpe oleracea showed lower desmosterol/campesterol (p = 0.026) and desmosterol/ β-sitosterol (p = 0.006) ratios than controls. Conclusions: Consumption of Euterpe oleracea extract markedly improved the lipid profile and attenuated atherosclerosis. These effects were related in part to a better balance in the synthesis and absorption of sterols. J Atheroscler Thromb, 2012; 19:237-245.

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Section: Histopathology and Immunohistochemistrysupporting

confidence: 63%

Euterpe Oleracea (Açai) Modifies Sterol Metabolism and Attenuates Experimentally-Induced Atherosclerosis

Feio

Izar

Ihara

et al. 2012

JAT

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“…oleracea Mart. is a botanical species that is widely used as food and its fruit, known as açaí berries, presents considerable potential for the development of new medicines, being therapeutically used by rural inhabitants especially in Amazon region (Calvazara, 1972;Rodrigues et al, 2006). Our literature review showed that there are no previous studies involving the in vitro assessment of the genotoxic or antigenotoxic effects of EOO.…”

Section: Resultsmentioning

confidence: 93%

Research Article First cytotoxic, genotoxic, and antigenotoxic assessment of Euterpe oleracea fruit oil (açaí) in cultured human cells.

Marques¹,

Tsuboy²,

Carvalho³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Euterpe oleracea Mart., popularly known as "açaí", is a tropical fruit from the Amazon region where it has considerable economic importance. Açaí has been used as food and for several medicinal purposes. Despite the widespread use of this fruit, there is 2 E.S. Marques et al. Genetics and Molecular Research 16 (3): gmr16039700 a lack of data regarding the safety of using this fruit oil exclusively. Therefore, we evaluated the in vitro cytotoxic, genotoxic, and antigenotoxic effects of E. oleracea fruit oil (EOO) in cultured human lymphocytes (non-metabolizing cells) and HepG2 cell line (human hepatoma) (metabolizing cells) by using MTT, comet, and micronucleus assays. A wide range of EOO concentrations was tested with a preliminary MTT assay, which allowed selecting five concentrations for comet and micronucleus assays: 2.5, 10, 100, 500, and 1000 µg/mL. The results showed that none of the EOO tested concentrations presented cytotoxic effects. The genotoxic assessment revealed an absence of significant DNA and chromosome damage in human lymphocytes and HepG2 cells but did not show chemoprotection against the DNA damage induced by methyl methanesulfonate and benzo [a]pyrene, used as DNA-damaging agents.

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“…Still, there has not been enough research on the subject yet, which affects toxicological safety in some way 10 . Thus, it is important to conduct studies to understand the effect of the açaí seed in cachectic syndrome caused by cancer.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant effects of açaí seed ( Euterpe oleracea ) in anorexia-cachexia syndrome induced by Walker-256 tumor

et al. 2016

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PURPOSE:To assess antioxidant effects of açaí seed extract on anorexia-cachexia induced by Walker-256 tumor. METHODS:A population of 20 lab rats were distributed into four groups (n=5): Control Group (CG), which only received tumor inoculation. Experimental Group-100 (EG-100), with animals submitted to tumor inoculation and treated with seed extract in a 100 mg / ml concentration through gavage. Experimental , with animals submitted to tumor inoculation and treated with seed extract in a 200 mg / ml concentration. Placebo Group (GP), which received tumor inoculation and ethanol-water solution. We analyzed proteolysis, lipid peroxidation, tumor diameter and weight. RESULTS:Lipid peroxidation was representative only in the cerebral cortex, where there was more oxidative stress in rats treated with the extract (p = 0.0276). For proteolysis, there was less muscle damage in untreated rats (p = 0.0312). Only tumor diameter in treated rats was significantly lower (p = 0.0200) compared to untreated ones. CONCLUSIONS:The açaí seed extract showed no beneficial effect on the general framework of the cachectic syndrome in lab rats.However, some anticarcinogenic effects were observed in the tumor diameter and weight.

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Total Oxidant Scavenging Capacity of Euterpe oleracea Mart. (Açaí) Seeds and Identification of Their Polyphenolic Compounds

Cited by 128 publications

References 23 publications

Euterpe Oleracea (Açai) Modifies Sterol Metabolism and Attenuates Experimentally-Induced Atherosclerosis

Euterpe Oleracea (Açai) Modifies Sterol Metabolism and Attenuates Experimentally-Induced Atherosclerosis

Research Article First cytotoxic, genotoxic, and antigenotoxic assessment of Euterpe oleracea fruit oil (açaí) in cultured human cells.

Antioxidant effects of açaí seed ( Euterpe oleracea ) in anorexia-cachexia syndrome induced by Walker-256 tumor

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