Total mouth photodynamic therapy mediated by red LED and porphyrin in individuals with AIDS

Silva, Francine Cristina da; Rosa, Luciano Pereira; Jesus, Iasmym Mendes de; Santos, Gabriel Pinto de Oliveira; Inada, Natália Mayumi; Blanco, Kate Cristina; Araújo, Thalita Santos Dantas; Bagnato, Vanderlei Salvador

doi:10.1007/s10103-021-03377-z

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Though the treatment was able to reduce the general count of microorganisms in the oral cavity, the reduction in the number of Log10 CFU/ml of Candida spp. was not significant (da Silva et al, 2022). Wiench et al introduced aPDT using toluidine blue O and a 635 nm diode laser with the energy density of 24 J/cm 2 , 400 mW power, and 30 s irradiation time as a possible therapeutic approach in future clinical studies (Wiench et al, 2019).…”

Section: Applications Of Apdt In the Treatment Of Oral Fungal Infectionsmentioning

confidence: 99%

Clinical applications of antimicrobial photodynamic therapy in dentistry

et al. 2023

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Given the emergence of resistant bacterial strains and novel microorganisms that globally threaten human life, moving toward new treatment modalities for microbial infections has become a priority more than ever. Antimicrobial photodynamic therapy (aPDT) has been introduced as a promising and non-invasive local and adjuvant treatment in several oral infectious diseases. Its efficacy for elimination of bacterial, fungal, and viral infections and key pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Candida albicans, and Enterococcus faecalis have been investigated by many invitro and clinical studies. Researchers have also investigated methods of increasing the efficacy of such treatment modalities by amazing developments in the production of natural, nano based, and targeted photosensitizers. As clinical studies have an important role in paving the way towards evidence-based applications in oral infection treatment by this method, the current review aimed to provide an overall view of potential clinical applications in this field and summarize the data of available randomized controlled clinical studies conducted on the applications of aPDT in dentistry and investigate its future horizons in the dental practice. Four databases including PubMed (Medline), Web of Science, Scopus and Embase were searched up to September 2022 to retrieve related clinical studies. There are several clinical studies reporting aPDT as an effective adjunctive treatment modality capable of reducing pathogenic bacterial loads in periodontal and peri-implant, and persistent endodontic infections. Clinical evidence also reveals a therapeutic potential for aPDT in prevention and reduction of cariogenic organisms and treatment of infections with fungal or viral origins, however, the number of randomized clinical studies in these groups are much less. Altogether, various photosensitizers have been used and it is still not possible to recommend specific irradiation parameters due to heterogenicity among studies. Reaching effective clinical protocols and parameters of this treatment is difficult and requires further high quality randomized controlled trials focusing on specific PS and irradiation parameters that have shown to have clinical efficacy and are able to reduce pathogenic bacterial loads with sufficient follow-up periods.

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Section: Applications Of Apdt In the Treatment Of Oral Fungal Infectionsmentioning

confidence: 99%

Clinical applications of antimicrobial photodynamic therapy in dentistry

et al. 2023

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“…aPDT can be an efficient approach to dealing with the Monkeypox virus. The use of aPDT, which combines light and a photosensitizing substance to kill microorganisms, is advocated as a complementary treatment for various viral infections [17] , [18] , [19] , [20] , [21] , [22] . Natural products have gained major interest among scientists as photosensitizers due to their unique chemical structures and properties.…”

Section: Introductionmentioning

confidence: 99%

Natural photosensitizers potentiate the targeted antimicrobial photodynamic therapy as the Monkeypox virus entry inhibitors: An in silico approach

Pourhajibagher

Bahador

2023

Photodiagnosis and Photodynamic Therapy

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“…Porphyrins have been used as linkers in metal and covalent organic frameworks and for a wide variety of applications, such as photovoltaics, photocatalysis, and energy storage [ 12 , 13 , 14 ]. Porphyrins have also been explored for biomedical applications, photodynamic therapy, sensing and spintronics [ 15 , 16 , 17 , 18 ]. Despite the numerous photonic applications utilizing porphyrin materials, our understanding of energy migration in these synthetic materials is still relatively limited.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembly-Directed Exciton Diffusion in Solution-Processable Metalloporphyrin Thin Films

Shibu¹,

Middleton²,

Kwiatkowski³

et al. 2021

Molecules

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The study of excited-state energy diffusion has had an important impact in the development and optimization of organic electronics. For instance, optimizing excited-state energy migration in the photoactive layer in an organic solar cell device has been shown to yield efficient solar energy conversion. Despite the crucial role that energy migration plays in molecular electronic device physics, there is still a great deal to be explored to establish how molecular orientation impacts energy diffusion mechanisms. In this work, we have synthesized a new library of solution-processable, Zn (alkoxycarbonyl)phenylporphyrins containing butyl (ZnTCB4PP), hexyl (ZnTCH4PP), 2-ethylhexyl (ZnTCEH4PP), and octyl (ZnTCO4PP) alkoxycarbonyl groups. We establish that, by varying the length of the peripheral alkyl chains on the metalloporphyrin macrocycle, preferential orientation and molecular self-assembly is observed in solution-processed thin films. The resultant arrangement of molecules consequently affects the electronic and photophysical characteristics of the metalloporphyrin thin films. The various molecular arrangements in the porphyrin thin films and their resultant impact were determined using UV-Vis absorption spectroscopy, steady-state and time-resolved fluorescence emission lifetimes, and X-ray diffraction in thin films. The films were doped with C60 quencher molecules and the change in fluorescence was measured to derive a relative quenching efficiency. Using emission decay, relative quenching efficiency, and dopant volume fraction as input, insights on exciton diffusion coefficient and exciton diffusion lengths were obtained from a Monte Carlo simulation. The octyl derivative (ZnTCO4PP) showed the strongest relative fluorescence quenching and, therefore, the highest exciton diffusion coefficient (5.29 × 10−3 cm2 s−1) and longest exciton diffusion length (~81 nm). The octyl derivative also showed the strongest out-of-plane stacking among the metalloporphyrins studied. This work demonstrates how molecular self-assembly can be used to modulate and direct exciton diffusion in solution-processable metalloporphyrin thin films engineered for optoelectronic and photonic applications.

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Total mouth photodynamic therapy mediated by red LED and porphyrin in individuals with AIDS

Cited by 5 publications

References 22 publications

Clinical applications of antimicrobial photodynamic therapy in dentistry

Clinical applications of antimicrobial photodynamic therapy in dentistry

Natural photosensitizers potentiate the targeted antimicrobial photodynamic therapy as the Monkeypox virus entry inhibitors: An in silico approach

Self-Assembly-Directed Exciton Diffusion in Solution-Processable Metalloporphyrin Thin Films

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