Total mandibular reconstruction for massive osteolysis of the mandible (Gorham–Stout syndrome)

Paley, Martin; Lloyd, Christopher J.; Penfold, Christopher N.

doi:10.1016/j.bjoms.2004.09.008

Cited by 55 publications

(27 citation statements)

References 7 publications

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“…It has been reported that progression of bone graft has led to failure of reconstruction (Woodward et al, 1981;Kulenkampff et al, 1990;Paley et al, 2005); however, reconstruction using prostheses seems to be more effective. In our case series, six patients who underwent reconstruction using prostheses had the disorder controlled and three patients who underwent reconstruction using bone grafts had a symptom progression.…”

Section: Discussionmentioning

confidence: 99%

Gorham-Stout syndrome in mainland China: a case series of 67 patients and review of the literature

Yuan

et al. 2013

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Gorham-Stout syndrome (GSS) is a rare disorder of uncertain etiology and unpredictable prognosis. This study aims to present a comprehensive understanding of this rare entity. Methods: A literature search in PubMed and three Chinese databases was performed to screen histologically proven GSS cases among Chinese residents in the mainland. We analyzed the patients' clinical characteristics, the value of different treatment modalities and their influence on the clinical outcome. Results: Sixty-seven cases were finally enrolled. There were 43 men (64.2%) and 24 women (35.8%). The mean age at diagnosis was 28 years (1.5-71 years). The most common clinical symptoms included pain (n=40, 59.7%), functional impairment (n=13, 19.4%), and swelling (n=12, 17.9%). The radiographic presentation of 37 cases (55.2%) was disappearance of a portion of the bone. The others presented as radiolucent foci in the intramedullary or subcortical regions. A total of 42 cases provided data on therapy, these included surgery (n=27, 40.3%), radiation therapy (n=6, 9.0%), surgery combined with radiation therapy (n=2, 3.0%), and medicine therapy (n=7, 10.4%). For 30 of these 42 cases, follow-up data were available: 21 cases had the disorder locally controlled and 9 had a symptom progression. Fortunately, the disease is not fatal in the majority of cases. Conclusions: GSS has no specific symptoms and it should be taken into consideration when an unclear massive osteolysis occurs. The efficacies of different treatment modalities are still unpredictable and further research is required to assess the values of different treatments.

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Section: Discussionmentioning

confidence: 99%

Gorham-Stout syndrome in mainland China: a case series of 67 patients and review of the literature

Yuan

et al. 2013

J. Zhejiang Univ. Sci. B

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show abstract

“…A large number of treatments have been proposed, including sodium fluoride, vitamin D, calcium, alpha interferon [12], calcitonin and reconstructive surgery with a micro-vascularized graft [10], but the results have been variable [14,25]. Radiotherapy has achieved positive results due to the radio-sensitive nature of endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…Micro-vascularized or free bone grafts for the treatment of massive osteolysis have been reported, with different degrees of success depending over all on whether the disease is active at the time of the graft [10,14,25]. Although a graft make work for a particular period of time, long-term follow-up is needed, as the disease may involve the soft tissue, which could lead to osteoclastic activity in the grafted tissue [10].…”

Section: Discussionmentioning

confidence: 99%

“…Gorham-Stout syndrome has an unknown etiology [3,[7][8][9][10]. Diagnosis is difficult, especially in the early stages.…”

Section: Introductionmentioning

confidence: 99%

“…The syndrome is normally wrongly diagnosed in the maxillofacial region due to its rarity and bizarre clinical characteristics [9]. A number of different treatments have been proposed, with a huge variety in long-term results [10][11][12]. The clinical evolution of the disease normally requires multiple treatments.…”

Section: Introductionmentioning

confidence: 99%

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