Total Laryngectomy Versus Larynx Preservation for T4a Larynx Cancer: Patterns of Care and Survival Outcomes

Clinical Outcomes of Definitive and Postoperative Radiotherapy for Stage I-IVB Hypopharyngeal Cancer

“…In a randomized control trial in 1997, Beauvillain et al reported that induction chemotherapy followed by surgery gave significantly better local control and overall survival rate than did induction chemotherapy followed by radiotherapy (5-year local control rate, 63% vs. 39%; 5-year overall survival rate, 37% vs. 19%, respectively) (18). Furthermore, a study of the National Cancer Database showed that total laryngectomy led to a significantly better overall survival rate than did chemoradiotherapy for laryngeal preservation in patients with T4a laryngeal cancer (19). Harris et al retrospectively compared primary surgery followed by radiotherapy to definitive radiotherapy in locally advanced hypopharyngeal cancer, including 82% with stage IV (20).…”

Evidence and evidence gaps of laryngeal cancer surgery

“…After primary total laryngectomy it was significantly longer and amounted to 61 months whereas the median survival after primary radiochemotherapy was 39 months. Additionally, it was revealed that patients who were treated in high-volume hospitals underwent more frequently total laryngectomy [141]. This aspect corresponds to a better patient selection in specialized centers.…”

Neck Management with Total Laryngectomy and Adjuvant Radiotherapy in Locally Advanced Larynx Cancer

“…In 2016, there will be an estimated 13,430 new cases and 3,620 deaths from laryngeal cancer [1]. While larynx preservation chemoradiation is the most frequently employed modality, patients with full-thickness thyroid cartilage invasion and/or high-volume tumors necessitate primary total laryngectomy with or without postoperative radiation therapy (RT).…”