Clinical Outcomes of Definitive and Postoperative Radiotherapy for Stage I-IVB Hypopharyngeal Cancer

Shirai, Katsuyuki; Saitoh, Jun‐ichi; Abe, Takanori; Kobayashi, Daijiro; Takakusagi, Yosuke; Takaysu, Yukihiro; Shino, Masato; Toyoda, Minoru; Takahashi, Katsumasa; Chikamatsu, Kazuaki; Ohno, Tatsuya; Nakano, Takashi

doi:10.21873/anticanres.11261

Cited by 14 publications

(10 citation statements)

References 27 publications

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“…Optimal treatment for locally advanced hypopharyngeal cancer is controversial, especially in T4a cancer. For T4a hypopharyngeal cancer, (chemo)radiotherapy showed a poor survival rate compared to the radical surgery, and the invasion of thyroid or cricoid cartilage were considered as to be difficult to preserve laryngopharyngeal function after chemoradiotherapy . Therefore, surgery is considered as the treatment of choice for T4a cancer.…”

Section: Introductionmentioning

confidence: 99%

Surgery vs. radiotherapy for locally advanced hypopharyngeal cancer in the contemporary era: A population‐based study

Kim

Lee

2018

Cancer Medicine

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ObjectivesTo compare overall survival (OS) in locally advanced hypopharyngeal cancer treated with surgery or definitive chemoradiotherapy in the contemporary era.MethodsFrom 2010 to 2015, data for patients diagnosed with hypopharyngeal cancer (T2‐T4aM0) and treated with total pharyngectomy with lymph node dissection (surgery group) or definitive radiotherapy and chemotherapy (chemoradiotherapy group) was retrieved from the SEER database. Multivariate analyses were performed in each subgroup divided according to T category (T2‐3 or T4a).ResultsThe number of patients in the surgery and chemoradiotherapy groups was 209 and 648, respectively. Among them, the number of T4a patients was 111 and 126 in each group. Three‐year OS rate in the surgery and chemoradiotherapy groups was 37.9% and 44.1%, respectively (P = 0.178). The 3‐year OS rate for the T2‐3 patients was 46.5% and 48.7% (P = 0.598), and the 3‐year OS rate for the T4a patients was 29.9% and 26.1% in the surgery and chemoradiotherapy groups, respectively (P = 0.439). On multivariate analysis, the chemoradiotherapy group was not inferior to the surgery group in T2‐T4a patients (Hazard ratio [HR] for the chemoradiotherapy group 0.889, 95% confidence interval [CI] 0.699‐1.129, P = 0.334), in T2‐3 patients (HR 0.932, 95% CI 0.699‐1.297, P = 0.675), and in T4a patients (HR 0.880, 95% CI 0.617‐1.256, P = 0.481).ConclusionsChemoradiotherapy for locally advanced hypophagyngeal cancer showed a comparable OS rate to surgery. For patients with T4a category cancer with high possibility of preserving the laryngopharyngeal function, chemoradiotherapy may be a promising alternative treatment.

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Section: Introductionmentioning

confidence: 99%

Surgery vs. radiotherapy for locally advanced hypopharyngeal cancer in the contemporary era: A population‐based study

Kim

Lee

2018

Cancer Medicine

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“…There have been few advances in improving overall and disease-free survival rates in the past decades for advanced, recurrent and metastatic disease (4)(5)(6). Surgical and conservative options are often limited in these cases, as certain cancers show significant resistance to chemo-and radiotherapy (7)(8)(9)(10)(11). While targeted therapy has been successful in other oncologic entities, there has been only one approval in HNSCC for cetuximab, a therapeutic antibody against epidermal growth factorreceptor (EGFR) (4,5).…”

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confidence: 99%

Spheroid-based 3D Cell Cultures Enable Personalized Therapy Testing and Drug Discovery in Head and Neck Cancer

Hagemann

Jacobi

Hahn

et al. 2017

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“…6,23 Organ preservation approaches are being increasingly utilized in head and neck cancers with RT and chemoradiotherapy (CRT), even for those older than 70 years at presentation. 14,24,25 Some are advocating this approach just for stage III disease, 18 ; however, for many, it is for all advanced disease. Edson, in a series of 98 patients, noted a functional laryngeal preservation rate of 76% at 2 years, with an advantage to concurrent CRT, however, for a grade 3 toxicity rate of 21% at 5 years.…”

Section: Figurementioning

confidence: 99%

Surgery is not the only determinant of an outcome in patients with hypopharyngeal carcinoma

Smee

Kotevski

2019

Head & Neck

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Background The aim of this study was to evaluate the outcomes in patients treated for hypopharyngeal carcinoma in a single‐center and the importance of considering how patient factors influence outcomes. Methods A retrospective review was conducted on patients who were seen at the Prince of Wales Hospital from 1968 to 2015. Kaplan‐Meier and Cox regression analyses were performed for each patient and treatment factor to investigate outcomes of local control, cancer‐specific survival (CSS), and ultimate local control. Results Three hundred thirty patients were analyzed. Significant multivariate predictors for improved local control and CSS were fitness for surgery, cancer operability, surgery with adjuvant radiotherapy, no treatment interruptions (P < .05). Five‐year local control (84%), CSS (50%), and ultimate local control (84%) rates were significantly higher in patients treated surgically with adjuvant radiotherapy, compared to single modality treatment (P < .05). Conclusion Patient factors influence the outcomes experienced by patients with hypopharyngeal carcinoma.

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Clinical Outcomes of Definitive and Postoperative Radiotherapy for Stage I-IVB Hypopharyngeal Cancer

Cited by 14 publications

References 27 publications

Surgery vs. radiotherapy for locally advanced hypopharyngeal cancer in the contemporary era: A population‐based study

Surgery vs. radiotherapy for locally advanced hypopharyngeal cancer in the contemporary era: A population‐based study

Spheroid-based 3D Cell Cultures Enable Personalized Therapy Testing and Drug Discovery in Head and Neck Cancer

Surgery is not the only determinant of an outcome in patients with hypopharyngeal carcinoma

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