Total Iron-binding Capacity Calculated from Serum Transferrin Concentration or Serum Iron Concentration and Unsaturated Iron-binding Capacity

Yamanishi, Hiroshi; Iyama, Shigeru; Yamaguchi, Yoshihiro; Kanakura, Yuzuru; Iwatani, Yoshinori

doi:10.1373/49.1.175

Cited by 83 publications

(63 citation statements)

References 11 publications

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“…Although some articles suggest that the relation between transferrin and TIBC is not fixed, others found that when each test is measured precisely and without bias, the ratio of TIBC (in mol/l) to transferrin (in g/l) is indeed close to the expected value of 25.0 [25,26] . Also, recent studies found high significant correlations between the TIBC and the serum transferrin values, even without this proposed calibration [27] .…”

Section: Discussionmentioning

confidence: 96%

Heritability of Serum Iron, Ferritin and Transferrin Saturation in a Genetically Isolated Population, the Erasmus Rucphen Family (ERF) Study

Njajou¹,

Alizadeh²,

Aulchenko³

et al. 2006

Hum Hered

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Background: Iron has been implicated in the pathogenesis of various disorders. Mutations in the HFE gene are associated with an increase in serum iron parameters. The aim of this study was to estimate the heritability in serum iron parameters explained by HFE. Methods: Ninety families (980 subjects) were included in the present analysis. Heritability estimation was conducted using the variance component method. The likelihood ratio test was used to compare models. Phenotypic and genetic correlations between serum iron parameters were calculated. Results: The heritability (h² ± SE) estimates were 0.23 ± 0.07 (p < 0.0001) for iron, 0.29 ± 0.09 (p < 0.0001) for ferritin and 0.28 ± 0.07 (p < 0.0001) for transferrin saturation while adjusting for age, age² and sex. The HFE genotypes explained between 2 to 6% of the sex and age-adjusted variance in serum iron, ferritin and transferrin saturation. There was a high genetic correlation between serum iron parameters, suggesting pleiotropy between these traits. Conclusion: A substantial proportion of the variance of iron, ferritin and transferrin saturation can be explained by additive genetic effects, independent of sex and age. The HFE genotypes explained a considerable proportion of serum iron parameters and may be an important factor in the complex iron network.

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Section: Discussionmentioning

confidence: 96%

Heritability of Serum Iron, Ferritin and Transferrin Saturation in a Genetically Isolated Population, the Erasmus Rucphen Family (ERF) Study

Njajou¹,

Alizadeh²,

Aulchenko³

et al. 2006

Hum Hered

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“…Measurements of SI, TIBC, and TSAT are useful for the clinical diagnosis of iron-deficiency anemia [32]. SI is the amount of circulating iron that is bound to transferrin.…”

Section: Si Tibc and Tsat Levels Of Ratsmentioning

confidence: 99%

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Xiao

Lei

Wang

et al. 2015

Biol Trace Elem Res

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This study aims to investigate the effects of a tripeptide iron (REE-Fe) on iron-deficiency anemia rats. Sprague-Dawley rats were randomly divided into seven groups: a normal control group, an iron-deficiency control group, and iron-deficiency groups treated with ferrous sulfate (FeSO4), ferrous glycinate (Fe-Gly), or REE-Fe at low-, medium-, or high-dose groups. The rats in the iron-deficiency groups were fed on an iron-deficient diet to establish iron-deficiency anemia (IDA) model. After the model established, different iron supplements were given to the rats once a day by intragastric administration for 21 days. The results showed that REE-Fe had effective restorative action returning body weight, organ coefficients, and hematological parameters in IDA rats to normal level. In addition, comparing with FeSO4 or Fe-Gly, high-dose REE-Fe was more effective on improving the levels of renal coefficient, total iron-binding capacity, and transferrin. Furthermore, the liver hepcidin messenger RNA (mRNA) expression in the high-dose group was significantly higher (p < 0.05) than that in the FeSO4 or Fe-Gly group and showed no significant difference (p > 0.05) with the normal control group. The findings suggest that REE-Fe is an effective source of iron supplement for IDA rats and might be exploited as a new iron fortifier.

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“…We reported recently that total ironbinding capacity (TIBC) values calculated from serum iron and unsaturated iron-binding capacity (UIBC) values were significantly lower than those obtained by a direct and fully automated TIBC assay (1,2 ). We also reported that slopes of regression lines for calculated TIBC values plotted against serum transferrin (TRF) were ϳ7% lower than the theoretical ratio of TIBC to TRF (TIBC/TRF ϭ 25.1 mol/g).…”

Section: To the Editormentioning

confidence: 99%

“…With a complete lack of both transferrin N-glycans (2,10,11 ), the structure of asialotransferrin is different from the structure(s) of the non-CDT isoforms. Thus, there is the possibility of raising a specific antibody that binds strongly to the analyte (asialotransferrin), e.g., to an epitope near or at the original point of attachment of the carbohydrate chain(s).…”

mentioning

confidence: 99%

Modification of the Colorimetric Assay for Serum Unsaturated Iron-binding Capacity

et al. 2003

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Total Iron-binding Capacity Calculated from Serum Transferrin Concentration or Serum Iron Concentration and Unsaturated Iron-binding Capacity

Cited by 83 publications

References 11 publications

Heritability of Serum Iron, Ferritin and Transferrin Saturation in a Genetically Isolated Population, the Erasmus Rucphen Family (ERF) Study

Heritability of Serum Iron, Ferritin and Transferrin Saturation in a Genetically Isolated Population, the Erasmus Rucphen Family (ERF) Study

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Modification of the Colorimetric Assay for Serum Unsaturated Iron-binding Capacity

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