Total intravenous anesthesia with propofol and S(+)-ketamine in rabbits

Cruz, Fernando Silvério Ferreira da; Carregaro, Adriano Bonfim; Raiser, Alceu Gaspar; Zimmerman, Marina; Lukarsewski, Rafael; Steffen, Renata

doi:10.1111/j.1467-2995.2009.00513.x

Cited by 19 publications

(25 citation statements)

References 31 publications

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“…Respiratory complications such as problematic airway maintenance and inadequately ventilation are most commonly occurred in anaesthesia 1,15 . Depressed or inadequate ventilation related death can be obtained in rabbit anaesthesia but ventilation support can prevent this complication 16 .…”

Section: Discussionmentioning

confidence: 99%

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The investigation of airway management capacity of v-gel and cobra-PLA in anaesthetised rabbits

et al. 2015

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PURPOSE:To evaluate the applicability and airway management capacity of v-gel ® and Cobra PLA in rabbit anaesthesia during assisted (AV) or controlled ventilation (CV). METHODS:This study was carried out in 44 adult New Zealand white rabbit. Baseline arterial pH, PaCO 2 and PaO 2 values were recorded. Anaesthesia was induced with 5 mg/kg xylasine and 35 mg/kg ketamine HCI combination. AV rabbits were assigned as;control (CG-AV; n=5), LMA (LMA-AV; n=5), cobra PLA (PLA-AV; n=5) and v-gel (v-gelAV; n=5). Rabbits have CV were also assigned as; ET (ET-CV; n=6), LMA (LMA-CV; n=6), cobraPLA (PLA-CV; n=6) and v-gel (v-gelCV; n=6). All measurements were repeated 1st, 5th, 15th and 30th mins during anaesthesia. RESULTS:The less insertion time, number of attempt and complications are recorded in v-gel applied rabbits compared to other apparatus. For arterial pH values significant differences are recorded in especially at 15th and 30th min between groups of CV (p<0.005 or p<0.001). All groups had similar results with each other during anaesthesia for PaCO 2 except for LMA-CV group. CONCLUSION:The v-gel may be used as airway device in rabbit anaesthesia undergoing AV or CV and also can be a suitable alternative to endotracheal tubes and laryngeal mask airway.

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Section: Discussionmentioning

confidence: 99%

“…Analysing arterial blood gas values at anesthetised rabbits is important due to some anaesthetics can cause depression of ventilation 15,25,26 . In our study, any significant change in terms of arterial pH values is not found in AV rabbits.…”

Section: Discussionmentioning

confidence: 99%

The investigation of airway management capacity of v-gel and cobra-PLA in anaesthetised rabbits

et al. 2015

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“…41 Other studies in rabbits have shown transient tachycardia that may be secondary to a concomitant hypovolemia. 10,14,31 Although not proven, these vascular changes in rabbits may be induced secondary to propofol induced endothelial damage. 42 In vitro studies in rats have shown that propofol induces vasodilation of the aorta.…”

mentioning

confidence: 94%

“…Studies in rats and rabbits have shown that administration of an additional sedative, analgesic, and/or dissociative anesthetic will reduce propofol doses required to induce or maintain anesthesia. 31,47 The practice of balanced anesthesia not only reduces the amount of propofol required to be given, which may in turn reduce potential adverse effects, but has the added benefit of applying analgesia, as propofol has no analgesic qualities.…”

mentioning

confidence: 99%

“…12,13,15,20,[25][26][27] Respiratory depression without apnea, including bradypnea and/or respiratory acidosis, has been observed in red-tailed hawks (Buteo jamaicensis), great horned owls (Bubo virginianus), koi (Cyprinus carpio), sturgeon (Acipenser oxyrinchus de soti), and rabbits. [28][29][30][31][32] In a single study in mallard ducks (Anas platyrhynchos), an increase in respiratory rate was reported after propofol induction. 33 Because these studies span a variety of species and include administration at a variety of dosages (Table 1), a dose dependent and species dependent nature of apnea or bradypnea is likely and clinicians should use caution and carefully monitor their patient while under propofol anesthesia.…”

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confidence: 99%

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