Total hip replacement using femoral neck bone to graft the dysplastic acetabulum. Follow-up study of 18 patients with old congenital dislocation of the hip

Inao, Shigenori; Gotoh, Eiji; Ando, Mifumi

doi:10.1302/0301-620x.76b5.8083261

Cited by 24 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The paracrine effect of MSCs is also well described; they secrete factors to promote angiogenesis [17,18] as well as various other growth factors and r bioactive molecules. They stimulate cell differentiation, modulate extracellular matrix, and promote bone formation and neovascularization.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Femoral Head of Patients with Hip Dysplasia is not as Osteogenic as Iliac Crest Bone Location

Hernigou¹

2017

J Stem Cell Ther Transplant

View full text Add to dashboard Cite

When Total Hip Arthroplasty (THA) is required in a patient with developmental dysplasia of the hip (DDH), bone defi ciency in the acetabular roof often remains a problem. The iliac crest (IC) has long been the preferred source of autograft material, but graft harvest is associated with frequent complications and pain. Autologous bone graft can also be obtained from the femoral head (FH) for reconstruction of the acetabulum in hip arthroplasty. However, in certain challenging clinical scenarios, incorporation of the femoral head autograft appears less successful than the iliac crest autograft. The difference in potential for proliferation and osteoblastic differentiation between the two sites has still not been evaluated; therefore, it is not known how to compensate for this difference when it is present. We designed this study to evaluate the number of mesenchymal stem cells (MSCs) in both the iliac crest and femoral head of the same patient. We also determined the best operating room procedure for loading the femoral head with MSCs to achieve equivalent numbers of MSCs as in the IC. Twenty patients (8 men and 16 women) undergoing THA for DDH were enrolled in the study. The mean age was 55.5 years (range 41-65 years). Bone marrow aspirates were obtained from three depths within the femoral head and the aspirates were quantifi ed relative to matched iliac crest aspirates that were obtained from the same patient at the same time. The cell count, progenitor cell concentration (cells/ mL marrow), and progenitor cell prevalence (progenitor cells/million nucleated cells) were calculated.Aspirates of FH marrow demonstrated less concentrations of mononuclear cells compared with matched controls from the iliac crest. Progenitor cell concentrations were consistently lower in FH aspirates compared to matched controls from the iliac crest (p = 0.05). The concentration of osteogenic progenitor cells was, on average, 40% lower in the FH aspirates than in the paired iliac crest samples (p = 0.05). However, with bone marrow aspirated from the iliac crest, we were able to load the femoral head autograft with suffi cient MSCs to obtain the same number as present in an iliac crest. With concentrated bone marrow from the IC, supercharging the femoral autograft with MSCs to numbers above that present in the IC was possible in the operating room, and the number of MSCs supercharged in the femoral head was predictable.Based on these fi ndings we suggest that FH graft supercharged with BM-MSCs from the IC is comparable to IC graft for osseous graft supplementation especially in THA for patients with DDH.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Graft resorption in hip revision with or without cement [18,[20][21][22][23][24] is probably due to different mechanical factors but also biological factors. The mechanical factors and the revascularization process have been extensively discussed in the literature.…”

Section: Discussionmentioning

confidence: 99%

The Femoral Head of Patients with Hip Dysplasia is not as Osteogenic as Iliac Crest Bone Location

Hernigou¹

2017

J Stem Cell Ther Transplant

View full text Add to dashboard Cite

show abstract

“…mit Darstellung der Planung bei Dysplasiekoxarthrose und Z. n. ehemaliger Pfannendachplastik in Appositionstechnik. [11,13,17,23,26,35]; seltener wurden zementfreie Pfannen eingesetzt [19,22]. Nach kurzen und mittelfristigen Nachuntersuchungszeiträumen beschreiben viele Autoren gute bis sehr gute Ergebnisse [11,13,17,19,22,23,26,35,42] Die vorgestellte lnterpositionsarthroplastik ist als Modifikation und Weiterentwicklung der Nut-und Federplastik [28] aufzufassen und soll der direkten Krafteinleitung in den autologen Span, der wenn möglich mit seinen Trabekeln in den Kraftfluss ausgerichtet ist, Rechnung tragen.…”

Section: Methodikunclassified

Kurzfristige Ergebnisse der Interpositionsarthroplastik mittels autologem Femurkopfresektat in Kombination mit zementfreien Schraubpfannen zur Behandlung der Dysplasiecoxarthrose

Weingärtner

Fitz²,

Horn³

et al. 2000

Z Orthop Ihre Grenzgeb

View full text Add to dashboard Cite

show abstract

“…2,[10][11][12][13][14][15][16][17][18] The results with cementless components have been inconsistent. [19][20][21][22][23] The absence of satisfactory acetabular bone stock and poor positioning of the component have resulted in aseptic loosening and osteolysis due to polyethylene wear, particularly with first-generation cementless components, thereby compromising the results.…”

mentioning

confidence: 99%

The 15° face-changing acetabular component for treatment of osteoarthritis secondary to developmental dysplasia of the hip

Pedowitz

Yamaguchi

Ahmad

et al. 2012

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

We report the use of a 15° face-changing cementless acetabular component in patients undergoing total hip replacement for osteoarthritis secondary to developmental dysplasia of the hip. The rationale behind its design and the surgical technique used for its implantation are described. It is distinctly different from a standard cementless hemispherical component as it is designed to position the bearing surface at the optimal angle of inclination, that is, < 45°, while maximising the cover of the component by host bone.

show abstract

Total hip replacement using femoral neck bone to graft the dysplastic acetabulum. Follow-up study of 18 patients with old congenital dislocation of the hip

Cited by 24 publications

References 0 publications

The Femoral Head of Patients with Hip Dysplasia is not as Osteogenic as Iliac Crest Bone Location

The Femoral Head of Patients with Hip Dysplasia is not as Osteogenic as Iliac Crest Bone Location

Kurzfristige Ergebnisse der Interpositionsarthroplastik mittels autologem Femurkopfresektat in Kombination mit zementfreien Schraubpfannen zur Behandlung der Dysplasiecoxarthrose

The 15° face-changing acetabular component for treatment of osteoarthritis secondary to developmental dysplasia of the hip

Contact Info

Product

Resources

About