Total Hip Arthroplasty with Hydroxyapatite-Coated Prostheses

Jaffe, William L.; Scott, David F.

doi:10.1007/978-4-431-68529-6_16

Cited by 44 publications

(50 citation statements)

References 128 publications

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“…To achieve biological fixation of uncemented or pressfit implants, close apposition of bone to the implant surface and initial mechanical stability are required. 1 Osteoconductive coatings not only enhance both the integration of an implant with host bone and the strength of the bone-implant interface, but also prolong the implant's useful life. 2 Titanium and titanium alloy implants with such coatings are widely used to encourage biological fixation, 3 due to the biocompatibility and mechanical properties of the metals, and the stability and conductivity of the coatings.…”

Section: Introductionmentioning

confidence: 99%

Osseointegration on metallic implant surfaces: Effects of microgeometry and growth factor treatment

Frenkel

Simon

Alexander³

et al. 2002

J. Biomed. Mater. Res.

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Orthopedic implants often loosen due to the invasion of fibrous tissue. The aim of this study was to devise a novel implant surface that would speed healing adjacent to the surface, and create a stable interface for bone integration, by using a chemoattractant for bone precursor cells, and by controlling tissue migration at implant surfaces via specific surface microgeometry design. Experimental surfaces were tested in a canine implantable chamber that simulates the intramedullary bone response around total joint implants. Titanium and alloy surfaces were prepared with specific microgeometries, designed to optimize tissue attachment and control fibrous encapsulation. TGF beta, a mitogen and chemoattractant (Hunziker EB, Rosenberg LC. J Bone Joint Surg Am 1996;78:721-733) for osteoprogenitor cells, was used to recruit progenitor cells to the implant surface and to enhance their proliferation. Calcium sulfate hemihydrate (CS) was the delivery vehicle for TGF beta; CS resorbs rapidly and appears to be osteoconductive. Animals were sacrificed at 6 and 12 weeks postoperatively. Results indicated that TGFbeta can be reliably released in an active form from a calcium sulfate carrier in vivo. The growth factor had a significant effect on bone ingrowth into implant channels at an early time period, although this effect was not seen with higher doses at later periods. Adjustment of dosage should render TGF beta more potent at later time periods. Calcium sulfate treatment without TGF beta resulted in a significant increase in bone ingrowth throughout the 12-week time period studied. Bone response to the microgrooved surfaces was dramatic, causing greater ingrowth in 9 of the 12 experimental conditions. Microgrooves also enhanced the mechanical strength of CS-coated specimens. The grooved surface was able to control the direction of ingrowth. This surface treatment may result in a clinically valuable implant design to induce rapid ingrowth and a strong bone-implant interface, contributing to implant longevity.

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Section: Introductionmentioning

confidence: 99%

Osseointegration on metallic implant surfaces: Effects of microgeometry and growth factor treatment

Frenkel

Simon

Alexander³

et al. 2002

J. Biomed. Mater. Res.

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show abstract

“…To increase the bioactivity and/or to achieve a strong bone/implant fixation, many surface modification techniques are being intensively studied. [1][2][3][4][5][6][7][8] It has been reported that proper surface topography could not only improve the bone integration of implants, 3,8 but could also influence cell organization. 5,9,10 This is the first step to organize bone tissue, which is mechanically anisotropic, so that a strong implant/bone interface can be achieved.…”

Section: Introductionmentioning

confidence: 99%

“…However, a thin layer of hydroxyapatite (HA) has been widely accepted as a biocoating to enhance the osteoconductivity of titanium implants. 2,4,[11][12][13] One of the main problems with HA coating is its mechanical integrity. Residual stresses, due to either specific processing techniques or thermal expansion mismatch, exist in many of the coating methods and can cause coatings to crack or debond under external loading.…”

Section: Introductionmentioning

confidence: 99%

Patterning hydroxyapatite biocoating by electrophoretic deposition

Wang¹,

Hu²

2003

J Biomedical Materials Res

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Patterned bioceramic coatings may find potential applications in orthopedic implants and biosensors. In this study, various hydroxyapatite (HA) patterns were created on silicon and titanium substrates. Electrophoretic deposition technique was used together with surface patterning of the cathode specimen. When gold/palladium patterns (hexagons, spherical dots, etc.) were created on the cathode surface, HA colloidal particles in ethanol would preferentially deposit on the gold-coated area and form patterns. When silicon, instead of gold, was evaporated onto a conducting cathode surface, HA mainly deposited on the exposed area of the substrate. Detailed mechanisms for forming HA patterns may involve local concentration of the electric field when a second metal is patterned on the cathode. The difference in electric field across the two metals on the cathode also enhances HA patterning through an electrohydrodynamic process. This study demonstrated the possibility and flexibility of electrophoretic deposition in patterning charged particles onto a substrate.

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“…HA is often used as a bone filler, or coating for metal implants to enhance fixation of the implant to bone tissue [6]. Though HA has shown promising clinical outcomes [7,8], some reports have suggested that HA coatings can produce nanoparticulate debris causing inflammation in the body [9,10]. This nanoparticle debris is recognized as foreign material by the innate immune system which subsequently initiates the recruitment and activation of inflammatory cells such as neutrophils, blood monocytes, and macrophages [11,12].…”

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro evaluation of hydroxyapatite nanoparticle morphology on the acute inflammatory response

et al. 2016

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In vivo and in vitro evaluation of hydroxyapatite nanoparticle morphology on the acute inflammatory response. AbstractBiomedical implants have been widely used in bone repair applications. However, nanosized degradation products from these implants could elicit an inflammatory reaction, which may lead to implant failure. It is well known that the size, chemistry, and charge of these nanoparticles can modulate this response, but little is known regarding the role that the particle's morphology plays in inducing inflammation. The present study aims to investigate the effect of hydroxyapatite nanoparticle (HANPs) morphology on inflammation, in-vitro and in-vivo. Four distinct HANP morphologies were fabricated and characterized: long rods, dots, sheets, and fibers. Primary human polymorphonuclear cells (PMNCs), mononuclear cells (MNCs), and human dermal fibroblasts (hDFs) were exposed to HANPs and alterations in cell viability, morphology, apoptotic activity, and reactive oxygen species (ROS) production were evaluated, in vitro. PMNCs and hDFs experienced a 2-fold decrease in viability following exposure to fibers, while MNC viability decreased 5-fold after treatment with the dots. Additionally, the fibers stimulated an elevated ROS response in both PMNCs and MNCs, and the largest apoptotic behavior for all cell types. Furthermore, exposure to fibers and dots resulted in greater capsule thickness when implanted subcutaneously in mice. Collectively, these results suggest that nanoparticle morphology can significantly impact the inflammatory response.

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Total Hip Arthroplasty with Hydroxyapatite-Coated Prostheses

Cited by 44 publications

References 128 publications

Osseointegration on metallic implant surfaces: Effects of microgeometry and growth factor treatment

Osseointegration on metallic implant surfaces: Effects of microgeometry and growth factor treatment

Patterning hydroxyapatite biocoating by electrophoretic deposition

In vivo and in vitro evaluation of hydroxyapatite nanoparticle morphology on the acute inflammatory response

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