Total glucosides of paeony inhibits Th1/Th17 cells via decreasing dendritic cells activation in rheumatoid arthritis

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

“…As an anti-inflammatory and immune-regulatory drug, PF has been reported to have a clinically significant therapeutic effect on several inflammatory diseases, such as RA and Sjogren's syndrome. [2][3][4][5][6] vesicular formulations have demonstrated an impressive ability to enhance the permeability of RA drugs. 13 Studies have previously reported that liposomal encapsulation of RA drugs may improve drug accumulation in inflamed synovial tissue, but conventional liposomes often suffer from the shortcomings of instability, low encapsulation efficiency (EE), and limited drug delivery efficiency.…”

“…Equation (2) indicates that the amount of glycerol in water significantly affected the particle size of glycerosomes. Particle size tended to correlate positively with the amount of glycerol.…”

Clinical experience of combination therapy of infliximab and total glucosides of paeony for severe psoriasis with liver disorder history

“…In another research, anti-TNF drug-induced psoriasiform skin lesions are attributed to the infiltrates of interleukin (IL)-17A/ IL-22-expressing Th17 cells and IFN-expressing Th1 cells, and the severity of skin disease were positively correlated with the number of IL-17A-expressing T cells [27] . At the same time, TGP can inhibit the maturation and function of dendritic cells (DCS) by selectively blocking the activation of TLR4/5 activation in vivo, which in turn reduces T cell proliferation and leads to impaired Th1 and Th17 differentiation [28,29] . This might help to explain why the infliximab-induced exacerbation in Case 2 got resolved after combination with TGP.…”

Paeoniflorin suppresses inflammatory response in imiquimod-induced psoriasis-like mice and peripheral blood mononuclear cells (PBMCs) from psoriasis patients

“…Although the pathogenesis of psoriasis is not fully elucidated, it is widely accepted that cellular infiltration of T cells, DCs and neutrophils is important in the pathogenesis of psoriasis by provoking inflammation (Boehncke et al 2015). Several studies also supported that abundant production of inflammatory cytokines, such as interleukin (IL)-17, interferon (IFN)-γ, IL-6 and tumor necrosis factor-α (TNF-α) plays a key role in the development of this disease (Clark et al 2006;Lin et al 2012;Lowes et al 2008) Total glucosides of paeony (TGP) is an effective constituent purified and extracted from the dried root of Paeonia. The Paeonia lactiflora, which is called 'Shao Yao' in Chinese, has been widely used in China as a therapeutic drug for pain, cramp, congestion and giddiness for more than 1000 years.…”

“…PF has been used for the treatment of systemic lupus erythematosus (SLE), D r a f t rheumatoid arthritis (RA), Sjögren's syndrome (SS) and other inflammatory and autoimmune diseases (Lin et al 2012;Wang et al 2014;Zhao et al 2012) In order to further extend the understanding of the pharmacological functions of PF and to provide experimental evidence for its potential clinical use in the treatment of psoriasis, the therapeutic effects and the mechanisms of PF in imiquimod (IMQ)-induced psoriasis like mouse model were investigated. The effects of PF on the expression of inflammatory cytokines, such as IL-17, INF-γ, IL-6 and TNF-α in lesional skin in IMQ-induced mice and peripheral blood mononuclear cells (PBMCs) from patients with psoriasis vulgaris were also investigated.…”