Total glucosides of paeony inhibit the inflammatory responses of mice with allergic contact dermatitis by restoring the balanced secretion of pro-/anti-inflammatory cytokines

Wang, Chun; Yuan, Jun; Wu, Hua; Cao, Yan; Wang, Qingtong; Wu, Yu; Zhou, Peng; Xiao, Yang; Yu, Jun; Wei, Wei

doi:10.1016/j.intimp.2014.12.026

Cited by 39 publications

(28 citation statements)

References 32 publications

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“…Similar effects of TGP were reported in psoriatic arthritis patients and rheumatoid arthritis mice (Lin et al, 2012). TGP also could reduce the severity of skin inflammation through decreasing the production of IL-17 but increasing the production of IL-4 and IL-10 in the serum and lymphocyte supernatant of mice with allergic contact dermatitis (Wang et al, 2015).…”

Section: Discussionsupporting

confidence: 69%

Total glucosides of peony attenuates experimental autoimmune encephalomyelitis in C57BL/6 mice

Huang

Zhu

et al. 2015

Journal of Neuroimmunology

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Section: Discussionsupporting

confidence: 69%

Total glucosides of peony attenuates experimental autoimmune encephalomyelitis in C57BL/6 mice

Huang

Zhu

et al. 2015

Journal of Neuroimmunology

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“…TGP has been well known for a long time for the treatment of autoimmune diseases. It regulates inflammation responses by reducing lymphocytes proliferation, activation and cytokine secretion including IL-10, IL-2, IL-4, IL-17 and so on (Chen et al, 2008;Wang et al, 2015;Xu et al, 2014). So, based on the above report, we speculated that TGP might have regulatory effects on B lymphocytes in tumor microenvironment.…”

Section: Discussionmentioning

confidence: 88%

Protective Effects ofTotal Glucosides of Paeonyon N-nitrosodiethylamine-induced Hepatocellular Carcinoma in Rats via Down-regulation of Regulatory B Cells

Song

Yuan

et al. 2015

Immunological Investigations

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Total glucoside of paeony (TGP), extracted from the root of Paeonia Lactiflora, has been known to show anti-inflammatory, anti-oxidative, hepato-protective and immuno-regulatory activities. The aim of this present study was to determine the anti-tumor effect of TGP against N-nitrosodiethylamine (DEN)-induced hepatocellular carcinoma (HCC) in rats, and to find the related mechanisms. Rat HCC model was established by intragastrically administrating with DEN (8 mg/kg). We found the number of tumor nodules and the index of liver and spleen were increased in the model group compared with the normal group, and was significantly decreased by TGP. Additionally, TGP obviously improved the hepatic pathological lesions induced by DEN, and decreased the elevated levels of serum alanine aminotransferase (ALT), glutamic oxalacetic transaminase (AST), alkaline phosphatase (ALP) and alpha fetoprotein (AFP) by DEN. Moreover, TGP decreased the level of B cell-activating factor (BAFF) and the proportion of IL-10-producing regulatory B cells (Bregs), and the decrease of BAFF by TGP is positively correlated to the decrease of IL-10-producing Bregs by TGP. These results suggest that TGP had a good therapeutic action on DEN-induced HCC rats, which might be due to its down-regulation of Bregs through reducing the level of BAFF.

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“…Firstly, TGP has bidirectional regulatory effects on T lymphocytes and tends to favour immune cell balance [37]. It may adjust the balance of Th1/Th2 cytokines by decreasing proinflammatory cytokines and increasing anti-inflammatory cytokines [38, 39]. In addition, TGP can inhibit maturation and activation of dendritic cells, which leads to impaired Th1/Th17 differentiation in vivo and downregulation of the Th1/Th17 inflammatory response [40, 41].…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy and Safety of Total Glucosides of Paeony for Primary Sjögren’s Syndrome: A Systematic Review

Jin

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Objective To evaluate the clinical efficacy and safety of total glucosides of paeony (TGP) for primary Sjögren's syndrome (pSS). Methods Eight electronic databases were searched from their inception to July 2016. Clinical randomized controlled trials (RCTs) were included. The study quality was evaluated according to the standard suggested in the Cochrane Handbook. RevMan 5.1 was used for statistical analysis. Results Seven RCTs involving 443 patients were included. The results showed that TGP combined with an immunosuppressant (IS) showed greater efficacy for improving the saliva flow test of pSS compared to immunosuppressant alone (WMD −6.88, 95% CI −9.02 to −4.74, and P < 0.00001). And the same trend favouring TGP-IS dual combination was found in Schirmer test (WMD 1.63, 95% CI 0.26 to 3.01, and P = 0.02), ESR (WMD 7.33, 95% CI −10.08 to −4.59, and P < 0.00001), CRP (WMD −6.00, 95% CI −7.17 to −4.83, and P < 0.00001), IgM (WMD = −0.42, 95% CI −0.70 to 0.13, and P = 0.004), and IgG (WMD −3.22, 95% CI −4.32 to −2.12, and P < 0.00001) analysis. However, TGP did not affect IgA (WMD 0.53, 95% CI −1.34 to −0.29, and P = 0.20). The adverse events manifested no significant differences between the two groups. Conclusions The TGP-IS combination is superior to IS alone in the treatment of pSS. However, due to the low quality of included studies, high-quality RCTs are needed to confirm the beneficial effects of TGP.

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Total glucosides of paeony inhibit the inflammatory responses of mice with allergic contact dermatitis by restoring the balanced secretion of pro-/anti-inflammatory cytokines

Cited by 39 publications

References 32 publications

Total glucosides of peony attenuates experimental autoimmune encephalomyelitis in C57BL/6 mice

Total glucosides of peony attenuates experimental autoimmune encephalomyelitis in C57BL/6 mice

Protective Effects ofTotal Glucosides of Paeonyon N-nitrosodiethylamine-induced Hepatocellular Carcinoma in Rats via Down-regulation of Regulatory B Cells

Clinical Efficacy and Safety of Total Glucosides of Paeony for Primary Sjögren’s Syndrome: A Systematic Review

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