In this work, by using two kinds of viologen ligands three POM-based Compounds were obtained under hydrothermal conditions, namely [Ag I (bmypd) 0.5 (β-Mo 8 O 26 ) 0.5 ] (1)The structures were characterized by Fourier transform infrared spectroscopy (FT-IR), Powder X-ray diffraction (PXRD), X-ray photoelectron spectroscopy (XPS) and single crystal X-ray diffraction. Compounds 1-3 show excellent photochromic ability with fast photoresponse under the irradiation of ultraviolet light with different degrees of color changes. So compounds 1-3 can be used as visible ultraviolet detectors. Compounds 1-3 also possess photoluminescence properties with fast and excellent fluorescence quenching effect. Compounds 1-3 also can be used as inkless and erasable printing materials with suspensions of 1-3 applied to filter paper. Compounds 1-3 can also produce color changes in amine vapor environment, especially in an NH 3 atmosphere. Compounds 1-3 can be used as organic amine detectors.

Despite the high profile of aconine in WuTou injection, there has been no preparative technology or structural studies of its salt as the pharmaceutical product. The lack of any halide salt forms is surprising as aconine contains a tertiary nitrogen atom. In this work, aconine was prepared from the degradation of aconitine in Aconiti kusnezoffii radix (CaoWu). A green chemistry technique was applied to enrich the lipophilic‐poor aconine. Reaction of aconine with hydrochloride acid resulted in protonation of the nitrogen atom and gave a novel salt form (C25H42NO9+·Cl−·H2O; aconine hydrochloride monohydrate, AHM), whose cation in the crystal structure was elucidated based on extensive spectroscopic and X‐ray crystallographic analyses. The AHM crystal had a Z′ = 3 structure with three independent cation–anion pairs, with profound conformational differences among the aconine cations. The central framework of each aconine cation was compared with that of previously reported aconitine, proving that protonation of the nitrogen atom induced the structure rearrangement. In the crystal of AHM, aconine cations, chloride anions and water molecules interacted through inter‐species O—H…Cl and O—H…O hydrogen bonds; this complex hydrogen‐bonding network stabilizes the supramolecular structure. The seriously disordered solvent molecules were treated using the PLATON SQUEEZE procedure [Spek (2015). Acta Cryst. C71, 9–18] and their atoms were therefore omitted from the refinement. Bioactivity studies indicated that AHM promoted in vitro proliferative activities of RAW264.7 cells. Molecular docking suggested AHM could target cardiotoxic protein through the hydrogen‐bonding interactions. The structural confirmation of AHM offers a rational approach for improving the pharmaceutical technology of WuTou injection.

Objective To evaluate the clinical efficacy and safety of total glucosides of paeony (TGP) for primary Sjögren's syndrome (pSS). Methods Eight electronic databases were searched from their inception to July 2016. Clinical randomized controlled trials (RCTs) were included. The study quality was evaluated according to the standard suggested in the Cochrane Handbook. RevMan 5.1 was used for statistical analysis. Results Seven RCTs involving 443 patients were included. The results showed that TGP combined with an immunosuppressant (IS) showed greater efficacy for improving the saliva flow test of pSS compared to immunosuppressant alone (WMD −6.88, 95% CI −9.02 to −4.74, and P < 0.00001). And the same trend favouring TGP-IS dual combination was found in Schirmer test (WMD 1.63, 95% CI 0.26 to 3.01, and P = 0.02), ESR (WMD 7.33, 95% CI −10.08 to −4.59, and P < 0.00001), CRP (WMD −6.00, 95% CI −7.17 to −4.83, and P < 0.00001), IgM (WMD = −0.42, 95% CI −0.70 to 0.13, and P = 0.004), and IgG (WMD −3.22, 95% CI −4.32 to −2.12, and P < 0.00001) analysis. However, TGP did not affect IgA (WMD 0.53, 95% CI −1.34 to −0.29, and P = 0.20). The adverse events manifested no significant differences between the two groups. Conclusions The TGP-IS combination is superior to IS alone in the treatment of pSS. However, due to the low quality of included studies, high-quality RCTs are needed to confirm the beneficial effects of TGP.

Four polyoxometalate-based compounds were synthesized by hydrothermal method, namely [Ni2(HPtpi)(H2O)7.5Mo0.17(TeMo6O24)]·2.5H2O (1)，[Co(HPtpi)2(H2Ptpi)2(GeMo12O40)2]·4H2O (2) and {[M(Ptpi)(H2Ptpi)(H2O)][(γ-Mo8O26)0.5(α-Mo8O26)0.5]}·4H2O (M = Co in 3; Ni in 4) (Ptpi = 1-[2-(3-Pyridin-4-yl-[1,2,4]triazol-4-yl)-propyl]-imidazol). Compound 1 exhibits a 3D...