Total estrogenic activity and nonylphenol concentration in the Donggang River, Taiwan

Shue, Meei‐Fang; Chen, Fu‐An; Chen, Ting-Chien

doi:10.1007/s10661-009-1093-4

Cited by 18 publications

(8 citation statements)

References 65 publications

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“…The higher NP concentrations in the warm season confirm the relationship between NP contamination and sewage discharge into the surface water, because more detergents, showers with shower cream, and plastic ware were used in the warm season compared to the cold one [15]. As to the flow rate, concentrations of NP in the water’s low flow period were higher than in its high flow period due to a low dilution factor [13,16]. …”

Section: Occurrence Of Nonylphenol In the Environmentmentioning

confidence: 79%

Occurrence and Biodegradation of Nonylphenol in the Environment

Mao

Zheng

Zhang

et al. 2012

IJMS

133

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Nonylphenol (NP) is an ultimate degradation product of nonylphenol polyethoxylates (NPE) that is primarily used in cleaning and industrial processes. Its widespread use has led to the wide existence of NP in various environmental matrices, such as water, sediment, air and soil. NP can be decreased by biodegradation through the action of microorganisms under aerobic or anaerobic conditions. Half-lives of biodegradation ranged from a few days to almost one hundred days. The degradation rate for NP was influenced by temperature, pH and additions of yeast extracts, surfactants, aluminum sulfate, acetate, pyruvate, lactate, manganese dioxide, ferric chloride, sodium chloride, hydrogen peroxide, heavy metals, and phthalic acid esters. Although NP is present at low concentrations in the environment, as an endocrine disruptor the risks of long-term exposure to low concentrations remain largely unknown. This paper reviews the occurrence of NP in the environment and its aerobic and anaerobic biodegradation in natural environments and sewage treatment plants, which is essential for assessing the potential risk associated with low level exposure to NP and other endocrine disruptors.

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Section: Occurrence Of Nonylphenol In the Environmentmentioning

confidence: 79%

Occurrence and Biodegradation of Nonylphenol in the Environment

Mao

Zheng

Zhang

et al. 2012

IJMS

133

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“…Nevertheless, under these conditions treatment with the natural estrogen 17β-estradiol (E2) exhibited an EC 50 of ∼20 pM after a 24-h exposure period. However, as technology has improved, this assay has been modernized, and is now commonly carried out in a more standard 96-well plate format and with a 48-h exposure [100, 101]. Concurrent with this modernization has been the introduction of additional bioreporter cell lines that function in a similar manner.…”

Section: Evaluation Of Organic Toxicant-induced Health Risks Using mentioning

confidence: 99%

“…This study recognized varying degrees of correlation between chemically determined concentrations and total estrogenicity on a sample-by-sample basis, demonstrating that, although alkylphenols of GC/MS-determined concentrations could explain a large part of the estrogenic potency in the studied sediment samples, their abundance only provided little to a very low contribution toward the overall observed estrogenic effects in the water samples. These findings have since been repeated, suggesting the presence of other unintended or unknown estrogenic contaminants in studied sites [100]. However, despite their utility to assess biological effects rapidly, it is critical to acknowledge that these bioluminescent assays are not capable of identifying the causative agents, and therefore should not be used as a stand-alone technique for environmental evaluation.…”

Section: Evaluation Of Organic Toxicant-induced Health Risks Using mentioning

confidence: 99%

Detection of Organic Compounds with Whole-Cell Bioluminescent Bioassays

Smartt

et al. 2014

Advances in Biochemical Engineering/Biotechnology

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Natural and manmade organic chemicals are widely deposited across a diverse range of ecosystems including air, surface water, groundwater, wastewater, soil, sediment, and marine environments. Some organic compounds, despite their industrial values, are toxic to living organisms and pose significant health risks to humans and wildlife. Detection and monitoring of these organic pollutants in environmental matrices therefore is of great interest and need for remediation and health risk assessment. Although these detections have traditionally been performed using analytical chemical approaches that offer highly sensitive and specific identification of target compounds, these methods require specialized equipment and trained operators, and fail to describe potential bioavailable effects on living organisms. Alternatively, the integration of bioluminescent systems into whole-cell bioreporters presents a new capacity for organic compound detection. These bioreporters are constructed by incorporating reporter genes into catabolic or signaling pathways that are present within living cells and emit a bioluminescent signal that can be detected upon exposure to target chemicals. Although relatively less specific compared to analytical methods, bioluminescent bioassays are more cost-effective, more rapid, can be scaled to higher throughput, and can be designed to report not only the presence but also the bioavailability of target substances. This chapter reviews available bacterial and eukaryotic whole-cell bioreporters for sensing organic pollutants and their applications in a variety of sample matrices.

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“…In Taiwan, NP has been detected in most rivers, sludge, and sediments [21], [22], [23], [24], [25]. The unrestricted and intensive use of NPEs in detergents for daily activities may result in the high and ubiquitous levels of NP in Taiwan.…”

Section: Introductionmentioning

confidence: 99%

The Association between Nonylphenols and Sexual Hormones Levels among Pregnant Women: A Cohort Study in Taiwan

et al. 2014

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BackgroundNonylphenol (NP) has been proven as an endocrine disrupter and had the ability to interfere with the endocrine system. Though the health effects of NP on pregnant women and their fetuses are sustained, these negative associations related to the mechanisms of regulation for estrogen during pregnancy need to be further clarified. The objective of this study is to explore the association between maternal NP and hormonal levels, such as estradiol, testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH), and progesterone.MethodsA pregnant women cohort was established in North Taiwan between March and December 2010. Maternal urine and blood samples from the first, second, and third trimesters of gestation were collected. Urinary NP concentration was measured by high-performance liquid chromatography coupled with fluorescent detection. A mixed-effects model using a generalised estimating equation (GEE) was applied to assess the associations between maternal NP concentration and plasma hormones throughout the three trimesters.ResultsIn total, 162 singleton pregnant women completed this study through delivery. The geometric mean of creatinine-adjusted urinary NP concentrations were 4.27, 4.21, and 4.10 µg/g cre. in the first, second, and third trimesters respectively. A natural log-transformation of urinary NP concentrations were significantly associated with LH in the GEE model (β = −0.23 mIU/ml, p<0.01).ConclusionThis perspective cohort study demonstrates that negative association occurs between maternal NP exposure and plasma LH levels. The estrogen-mimic effect of NP might influence the negative feedback on LH during pregnancy.

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Total estrogenic activity and nonylphenol concentration in the Donggang River, Taiwan

Cited by 18 publications

References 65 publications

Occurrence and Biodegradation of Nonylphenol in the Environment

Occurrence and Biodegradation of Nonylphenol in the Environment

Detection of Organic Compounds with Whole-Cell Bioluminescent Bioassays

The Association between Nonylphenols and Sexual Hormones Levels among Pregnant Women: A Cohort Study in Taiwan

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