Total, Dialyzable, and Nondialyzable Postabsorptive Hydroxyproline

Niell, Harvey B.; Palmieri, Genaro M. A.; Neely, Charles L.; Maxwell, Theresa A.; Hopkins, Stanley C.; Soloway, Mark S.

doi:10.1001/archinte.1983.00350100097020

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Arch Intern Med

1983

DOI: 10.1001/archinte.1983.00350100097020

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Total, Dialyzable, and Nondialyzable Postabsorptive Hydroxyproline

Harvey B. Niell

Genaro M. A. Palmieri²,

Charles L. Neely³

et al.

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Cited by 8 publications

References 23 publications

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The role of tumor microenvironment in prostate cancer bone metastasis

Morrissey

Vessella

2007

J of Cellular Biochemistry

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Prostate cancer (PCa) epithelial cells require a number of factors to facilitate their establishment and growth at a distant site of metastasis. Their ability to adapt to their microenvironment, proliferate and recruit an underlying stroma is integral to the survival and growth of the metastasis. PCa predominantly metastasizes to the bone, and bone metastases are the main cause of morbidity. The bone marrow provides a permissive environment for the formation of a metastasis. In some cases, the cells may remain dormant for some time, eventually proliferating in response to an unknown "trigger." The marrow is rich in progenitor cells that differentiate into numerous cell types, producing new blood vessels, supporting fibroblasts, and an underlying extracellular matrix (ECM) that form the reactive stroma. By secreting a number of cytokines, growth factors and proteases they recruit auxiliary cells required to produce a functional stroma. These components are involved in a reciprocal interaction between the stroma and the PCa cells, allowing for the growth and survival of the tumor. Left unchecked, once a PCa tumor has established itself in the bone marrow it will eventually replace the marrow, interrupting bone homeostasis and typically promoting an osteoblastic response in the bone including osteoclastic events. The abundant deposition of new woven bone results in nerve compression, bone pain and an increase in fractures in patients with PCa bone metastases. This review will examine the tumor microenvironment, its role in facilitating tumor dissemination, growth and the resultant pathologies associated with PCa bone metastasis.

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The role of tumor microenvironment in prostate cancer bone metastasis

Morrissey

Vessella

2007

J of Cellular Biochemistry

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Skeletal surveys in multiple myeloma

et al. 1986

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Thirty-three patients with multiple myeloma were studied with serial skeletal surveys, serum immunoglobulin levels, and postabsorptive urinary hydroxyproline (Spot-HYPRO) determinations. Twenty receiving chemotherapy were also followed with skeletal surveys in order to evaluate bone response to treatment. A close association was found between skeletal findings and changes in immunoglobulin levels with positive correlation in 71% of the patients. A similar association was found between skeletal disease and Spot-HYPRO level changes in 65%. Five of 12 patients (42%) with partial or complete clinical response to chemotherapy, demonstrated improvement in the appearance of skeletal lesions. Positive correlation between the roentgenographic changes and clinical markers of myeloma as well as therapeutic response, indicates that skeletal surveys are useful and effective in monitoring patients with multiple myeloma.

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Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment

et al. 2010

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Total, Dialyzable, and Nondialyzable Postabsorptive Hydroxyproline

Cited by 8 publications

References 23 publications

The role of tumor microenvironment in prostate cancer bone metastasis

The role of tumor microenvironment in prostate cancer bone metastasis

Skeletal surveys in multiple myeloma

Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment

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