Total DDT and dieldrin content of human adipose tissue

Physiologically Based Pharmacokinetic Models for the Transport of Trichloroethylene in Adipose Tissue

“…This class includes organochloride pesticides such as aldrin, dieldrin, endrin, chlordane, heptachlor and DDT (Ahmad et al, 1988), as well as polychlorinated biphenyls (Ahmad et al, 1988;Lordo, 1996), polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-furans (Byard, 1987). Moreover, a variety of other halogenated organic compounds are known to accumulate in fat tissue (Ahmad et al, 1988).…”

“…This class includes organochloride pesticides such as aldrin, dieldrin, endrin, chlordane, heptachlor and DDT (Ahmad et al, 1988), as well as polychlorinated biphenyls (Ahmad et al, 1988;Lordo, 1996), polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-furans (Byard, 1987). Moreover, a variety of other halogenated organic compounds are known to accumulate in fat tissue (Ahmad et al, 1988). This tissue accumulation is related to the lipophilicity of the compounds and the low perfusion rate of adipose tissue, although studies in Di Francesco and Bickel (1985) and Minder (1994) suggest that the tissue distribution of lipophilic compounds is also dependent on binding competition between fat tissue and well-perfused lean tissues.…”

Research Related to Forensic Toxicology and Environmental Hazard

“…Toxicology is the branch of bio forensics that deals with the symptoms, adverse effect of poison drugs to living organisms with the out viewing the postmortem response of the addicted poison or drug addicted body their treatment their exposure their detection whereas toxicants and toxins both have major distributive differences toxins is mainly produced by the living organism in response to poisonous substance whereas toxicants if the foreign material extract from the manmade or human semi synthetic in nature which leads to ill biological process of the person and together this toxicants and toxin leads to become poison at a poison or poisoning substances at a point poisoning inherently lead to damage the psychological process of the human anatomy's the functioning of the accurate bio concentration of the chemicals produces ill effects in short interval of time. Whereas the pharmacopeia is a patent poison or a term through which gene related factors through which is a factor which decides for any poison to its adverse potential for making any substance a poison is decided by the evaluation of the dose response which is in graded dose response in an individual or the quantal dose response graded response is given to a population which results in greater magnitude of response as dose increased and in the quantal dose response relationship the percentage of the population affected uplift as the dose is raised this dose relationship gives a way to the broad way which is lethal dose ld50 which is defined as the measure of the amount of the substance needed to kill 50% of the tested population it measure the acute toxicity of the substances scientist mainly perform experiments on rats to test the animals basically the formula lies that that amount of chemical administered/100gm for small animal and in kgs for large animals they are entered through many routes whereas dermal injections are preferred (lc50) lethal concentration stands for the concentration of chemical in air which can kill 50% of tested animals [1][2][3][4][5]. These studies contribute to therapeutic dosage which determines any substance to be a healer or the toxic poison the therapeutic dosage is the ratio that compares as the blood concentration at which drug become toxic and the concentration at which it become effective the larger the therapeutic the safer is the drugs if the TI is smaller than which is the difference between the two concentration is small the drug toxicity appears and produces sign and symptoms on the body [6,7].…”

Forensic Toxicology Research to Investigate Environmental Hazard

“…Renal toxicity has been reported in humans and animals on acute [18], intermediate duration [19,20] and chronic exposure [21,22]. The liver is the most sensitive target of toxicity in intermediate duration exposure [19,23,24] and chronic-duration studies as in rats [22,25]. The adaptive changes in the liver have been observed in acutely exposed animals [26].…”