Total colonic dye-spray increases the detection of diminutive adenomas during routine colonoscopy: A randomized controlled trial

Randomized controlled trial of low-volume bowel preparation agents for colonic bowel preparation: 2-L polyethylene glycol with ascorbic acid versus sodium picosulfate with magnesium citrate

“…Adequate right colon cleansing was observed in more than 90 % of both the ITT and PP populations in the current study. Cleansing in the right colon is particularly important because flat polyps have significant premalignant potential and are found preferentially in the right colon [23,24]. However, bowel cleansing of the right colon is difficult because of concealment by opaque small-bowel effluent such as mucus and chime [25,26].…”

A Pilot Study of Fluorescent Imaging of Colorectal Tumors Using a γ-Glutamyl-Transpeptidase-Activatable Fluorescent Probe

“…Indeed, early detection of polyps and their subsequent endoscopic removal are the best ways to reduce colorectal cancer mortality [1,2,3]. Various image-enhanced endoscopy techniques, such as chromoendoscopy [4,5], narrow-band imaging [6,7], autofluorescence imaging [8] and confocal laser endomicroscopy [9], have improved the detection and characterization of colorectal neoplasms. However, laterally spreading tumors (LSTs) are still difficult to detect with such modalities [10,11,12,13,14].…”

The use of indigocarmine spray increases the colonoscopic detection rate of adenomas

“…Two recent randomized control trials [9][10][11] did not detect a statistically significant increase in adenoma detection with chromocolonoscopy although there was a significant increase on subgroup analysis. These two studies [9,11], however, failed to adequately control for confounding variables such as observation/withdrawal time, colonoscopic lavage and Japanese technical expertise.…”

“…An initial randomized trial by Brooker et al [9] in 2002 did not detect a statistically significant increase in overall adenoma detection with chromocolonoscopy although it did show a significant increase in the detection of diminutive adenomas of the proximal colon. Two recent randomized control trials [9][10][11] did not detect a statistically significant increase in adenoma detection with chromocolonoscopy although there was a significant increase on subgroup analysis. These two studies [9,11], however, failed to adequately control for confounding variables such as observation/withdrawal time, colonoscopic lavage and Japanese technical expertise.…”

“…Previous studies have shown that the prevalence of all neoplastic lesions using IC spray chromocolonoscopy ranges from 23 to 48% [2,[6][7][8][9][10][11], whereas the background prevalence in asymptomatic populations ranges from 25 to 40% [12]. An initial randomized trial by Brooker et al [9] in 2002 did not detect a statistically significant increase in overall adenoma detection with chromocolonoscopy although it did show a significant increase in the detection of diminutive adenomas of the proximal colon. Two recent randomized control trials [9][10][11] did not detect a statistically significant increase in adenoma detection with chromocolonoscopy although there was a significant increase on subgroup analysis.…”