Total caries experience in monozygotic and like-sexed dizygotic twins of caucasoid origin aged 5 to 15 years

Fairpo, C G

doi:10.1016/0003-9969(79)90125-0

Cited by 23 publications

(14 citation statements)

References 4 publications

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“…1959; Nakata ct al., 1967;Fairpo, 1979;Boraas et al, 1988] and parent-child similarities [Garn et al, 1976a] or sibling similarities [Garn et al, 1976b], Some reports have suggest ed a significant contribution of genetic factors to dental car ies, others not. The reason is that it is impossible to control the environmental factors affecting human beings.…”

Section: Discussionmentioning

confidence: 99%

Genetic Variation in Experimental Dental Caries in Four Inbred Strains of Rats

Kanamoto

Nonaka²,

Nakata

1994

Caries Res

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The relative contribution of the host genetic effect on the susceptibility to dental caries was examined. Four inbred strains of male rats (BN/Sea, F344/Ms, PVG/ cSea, and WKA/Sea) were inoculated with Streptococcus mutans and fed a cariogenic diet. The caries scores of the molar teeth were compared among these four strains, and the degree of genetic determination was estimated by analysis of variance. Statistically significant differences in caries scores were found among these strains (F344 > WKA > PVG/c > BN), and a high degree of genetic determination was obtained.

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Section: Discussionmentioning

confidence: 99%

Genetic Variation in Experimental Dental Caries in Four Inbred Strains of Rats

Kanamoto

Nonaka²,

Nakata

1994

Caries Res

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“…Aside from hereditary factors relating directly to enamel constitution, Goodman and co-workers thus established other genetically influenced factors as operative in caries etiology. Fairpo (1979), working in Leeds (England), expanded on previous studies of caries susceptibility by greatly increasing the "N" in the twin study population, and by evaluating total caries experience in a racially discreet, age-matched sample. The results carried previous conclusions (Finn and Caldwell, 1963;Akhmedov, 1973) into both the permanent and the deciduous dentitions, implicating a strong genetic factor in caries susceptibility.…”

Section: Dental Cariesmentioning

confidence: 99%

Genetic Influences in Caries and Periodontal Diseases

Hassell

Harris

1995

Critical Reviews in Oral Biology & Medicine

114

101

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Deciphering the relative roles of heredity and environmental factors ("nature vs. nurture") in the pathogenesis of dental caries and diseases of the periodontium has occupied clinical and basic researchers for decades. Success in the endeavor has come more easily in the case of caries; the complex interactions that occur between host-response mechanisms and putative microbiologic pathogens in periodontal disease have made elucidation of genetic factors in disease susceptibility more difficult. In addition, during the 30-year period between 1958 and 1987, only meager resources were targeted toward the "nature" side of the nature/nurture dipole in periodontology. In this article, we present a brief history of the development of genetic epistemology, then describe the three main research mechanisms by which questions about the hereditary component of diseases in humans can be addressed. A critical discussion of the evidence for a hereditary component in caries susceptibility is next presented, also from a historical perspective. The evolution of knowledge concerning possible genetic ("endogenous", "idiotypic") factors in the pathogenesis of inflammatory periodontal disease is initiated with an analysis of some foreign-language (primarily German) literature that is likely to be unfamiliar to the reader. We identify a turning point at about 1960, when the periodontal research community turned away from genetics in favor of microbiology research. During the past five years, investigators have re-initiated the search for the hereditary component in susceptibility to common adult periodontal disease; this small but growing body of literature is reviewed. Recent applications of in vitro methods for genetic analyses in periodontal research are presented, with an eye toward a future in which persons who are at risk-genetically predisposed-to periodontal disease may be identified and targeted for interventive strategies. Critical is the realization that genes and environment do not act independently of each other; the appearance or magnitude of heritability may differ with various environments.

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“…Twin studies have yielded some evidence for a genetic basis for susceptibility to dental cari e s , although it must be acknowledged that fluoride (and other environmental fa c t o rs presumably) can override this genetic influence. 128 MZ twins are more similar than DZ twins in relation to cari e s experience, [129][130][131] and this seems to apply particularly to the lower anterior teeth 132 and smooth surface approximal lesions. 133 The Minnesota Study of Twins Reared Apart (MSTRA) has produced the most conv i n c i n g evidence for heritability of caries susceptibility.…”

Section: Dental Cariesmentioning

confidence: 99%