Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk: Results from the EPIC cohort study

Sanikini, Harinakshi; Dik, Vincent K.; Siersema, Peter D.; Bhoo‐Pathy, Nirmala; Uiterwaal, Cuno S.P.M.; Peeters, Petra H.M.; González, Carlos; Zamora-Ros, Raúl; Overvad, Kim; Tjønneland, Anne; Roswall, Nina; Boutron-Ruault, Marie Christine; Fagherazzi, Guy; Racine, Antoine; Kühn, Tilman; Katzke, Verena; Boeing, Heiner; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Λάγιου, Παγώνα; Palli, Domenico; Grioni, Sara; Víneis, Paolo; Tumino, Rosario; Panico, Salvatore; Weiderpass, Elisabete; Skeie, Guri; Br̈aaten, Tonje; Huerta, José María; Sánchez‐Cantalejo, Emilio; Barricarte, Aurelio; Sonestedt, Emily; Wallström, Peter; Johansson, Ingegerd; Bradbury, Kathryn E.; Khaw, Kay Tee; Wareham, Nick; Huybrechts, Inge; Freisling, Heinz; Cross, Amanda J.; Riboli, Elio; Bueno-de-Mesquita, H. B.

doi:10.1002/ijc.29223

Cited by 19 publications

(23 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The risk of pancreatic cancer also appears to be higher in smokers (Gorham and others ; Harnack and others ) and nonconsumers of alcohol (Clavel and others ), whilereas genetic polymorphisms (CYP1A2 and GSTM1/GSTT1) can modify the relationship between coffee consumption and risk of breast (Kotsopoulos and others ; Bageman and others ; Ayari and others ), ovarian (Goodman and others ), and skin (Fortes and others , ) cancer. In some instances, only caffeinated coffee appears to be protective when compared with decaffeinated coffee (for example, in skin, endometrial, and some gastric cancers; Abel and others ; Bhoo‐Pathy and others ; Sanikini and others ) but in other studies, the opposite is true (for example, for ovarian, rectal and lung cancers; Michels and others ; Baker and others , ). Comparisons between other types of coffee preparations also produce equivocal results within the literature, for example for boiled (not filtered) versus filtered coffee (Nilsson and others ; Tverdal ) or hot versus iced coffee (Green and others ), and risks are also typically associated with heavy coffee consumption (Gullo and others ; Efird and others ; Luo and others ; Lueth and others ; Bissonauth and others ) or coffee abuse (Uzcudun and others ) compared to light/moderate coffee consumption.…”

Section: Resultsmentioning

confidence: 97%

A Comprehensive Overview of the Risks and Benefits of Coffee Consumption

Pourshahidi

Navarini

Petracco

et al. 2016

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Findings on both the health benefits and the potentially harmful effects of coffee consumption have been contradictory. However, the general scientific consensus is that moderate, regular coffee drinking by healthy individuals is either essentially benign or mildly beneficial. Results and generalizations are complicated by a number of factors, including differences in age, gender, health status, type of coffee preparation, serving size, and source of coffee. Coffee may have potential health benefits and risks, but causality cannot be established for either with the research currently available as these are largely based on observational data. This review aimed to provide a comprehensive overview of the risks and benefits of coffee consumption on health outcomes. A systematic search (search terms: "coffee" OR "coffee adj3" [consum * or intake * or drink * ]) of the literature (from 1970; humans; in English) using the electronic databases "OVID," "CINAHL," and "Web of Knowledge" returned 12405 results. Duplicates were removed, studies were screened (based on inclusion/exclusion criteria), and the remaining eligible studies (n = 1277) were used to collate an exhaustive list of the potential health benefits and risks of coffee consumption, which were grouped and are discussed with regard to major diseases/conditions (mortality, cardiovascular disease, cancer, and metabolic/liver/neurological disorders), atrisk/vulnerable groups, and specific coffee constituents. This qualitative assessment has shown that the health benefits (or null effects) clearly outweigh the risks of moderate coffee consumption in adult consumers for the majority of health outcomes considered. Results from this research may aid further qualitative and quantitative deterministic risk-benefit assessments of coffee consumption.

show abstract

Section: Resultsmentioning

confidence: 97%

A Comprehensive Overview of the Risks and Benefits of Coffee Consumption

Pourshahidi

Navarini

Petracco

et al. 2016

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

show abstract

“…Previously, dose-escalation studies have been performed in order to establish potentially suitable oral administration doses for caffeine in clinical treatments or animal experiments (59,60). The relationship between everyday caffeine intake and the risk of cancer is currently undefined (61,62). Notably, there is potential for caffeine to be used in the adjuvant setting during chemotherapy application (63,64).…”

Section: Discussionmentioning

confidence: 99%

Caffeine induces sustained apoptosis of human gastric cancer cells by activating the caspase-9/caspase-3 signalling pathway

Liu

Zhou

Tang

2017

Molecular Medicine Reports

View full text Add to dashboard Cite

Caffeine is one of the most widely consumed substances found in beverages, and has demonstrated anticancer effects in several types of cancer. The present study aimed to examine the anticancer effects of caffeine on gastric cancer (GC) cells (MGC-803 and SGC-7901) in vitro, and to determine whether the apoptosis-related caspase-9/−3 pathway is associated with these effects. The sustained antiproliferative effects of caffeine on gastric cancer were also investigated. GC cell viability and proliferation were evaluated using cell counting and colony forming assays, following treatment with various concentrations of caffeine. Flow cytometry was performed to assess cell cycle dynamics and apoptosis. Western blot analysis was conducted to detect the activity of the caspase-9/−3 pathway. The results indicated that caffeine treatment significantly suppressed GC cell growth and viability and induced apoptosis by activating the caspase-9/−3 pathway. Furthermore, the anticancer effects of caffeine appeared to be sustained, as the caspase-9/−3 pathway remained active following caffeine withdrawal. In conclusion, caffeine may function as a sustained anticancer agent by activating the caspase-9/−3 pathway, which indicates that it may be useful as a therapeutic candidate in gastric cancer.

show abstract

“…After retrieving the full text review of the remaining 16 articles for detailed evaluation, 3 articles were excluded because they did not report RRs and the corresponding 95 % CI of interest or provide sufficient data to calculate them. Finally, 13 prospective cohort studies [ 27 – 39 ] were included in the meta-analysis. Interobserver agreement (κ) between reviewers for study inclusion was very high (κ = 0.98).…”

Section: Resultsmentioning

confidence: 99%

Coffee consumption and the risk of gastric cancer: a meta-analysis of prospective cohort studies

Gan

et al. 2015

BMC Cancer

View full text Add to dashboard Cite

BackgroundSeveral observational studies suggest that coffee consumption may be associated with an increased risk of gastric cancer, but the results are inconsistent. We conducted a meta-analysis to evaluate the relationship of coffee consumption with gastric cancer risk and quantify the dose–response relationship between them.MethodsRelevant prospective studies were identified by a search of PubMed, Embase, and Web of Science to May 2015 and by reviewing the references of retrieved articles. Two independent reviewers extracted data and performed the quality assessment. A random-effects model was used to calculate the pooled risk estimates and 95 % confidence intervals (CI). The heterogeneity was assessed using the I2 statistic. Publication bias was assessed by using funnel plot, the Begg test and the Egger test.ResultsThirteen prospective cohort studies with 20 independent reports involving 3,368 patients with gastric cancer and 1,372,811 participants during a follow-up period ranging from 4.3–8 years were included. Compared with the lowest consumption level of coffee, the pooled relative risk (RR) was 1.13 (95 % CI: 0.94–1.35). The dose–response analysis indicated that, the RR of gastric cancer was 1.03 (95 % CI; 0.95–1.11) for per 3 cups/day of coffee consumption. Any nonlinear association of gastric cancer risk with coffee consumption was not found (P for nonlinearity = 0.68). Subgroup analyses indicated that the pooled RR for participants from the United States comparing the highest with the lowest coffee consumption was 1.36 (95 % CI, 1.06–1.75, I2 = 0 %). In addition, people with higher coffee consumption was associated with 25 % higher risk of gastric cancer in equal to or less than 10 years follow-up group (RR = 1.25; 95 % CI, 1.01–1.55, I2 = 0 %). Visual inspection of a funnel plot and the Begg’s and the Egger’s tests did not indicate evidence of publication bias.ConclusionsThis meta-analysis does not support the hypothesis that coffee consumption is associated with the risk of gastric cancer. The increased risk of gastric cancer for participants from the United States and equal to or less than 10 years follow-up group associated with coffee consumption warrant further studies.

show abstract

Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk: Results from the EPIC cohort study

Cited by 19 publications

References 51 publications

A Comprehensive Overview of the Risks and Benefits of Coffee Consumption

A Comprehensive Overview of the Risks and Benefits of Coffee Consumption

Caffeine induces sustained apoptosis of human gastric cancer cells by activating the caspase-9/caspase-3 signalling pathway

Coffee consumption and the risk of gastric cancer: a meta-analysis of prospective cohort studies

Contact Info

Product

Resources

About