Total body irradiation effects on the bone resorption mechanism in rats subjected to orthodontic movements

Praodi, R. J.; Ubios, A. M.; J, Mayo; Cabrini, R. L.

doi:10.1111/j.1600-0714.1973.tb01668.x

Cited by 11 publications

(4 citation statements)

References 6 publications

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“…Data obtained in this experiment clearly indicated that uranyl nitrate alters the healing of sockets afler tooth extraction by inhibition of bone formation. The use of standard histometric methods (18) repeatedly proved in alveolar bone (15,16,19,20) revealed this effect in every parameter considered.…”

Section: Discussionmentioning

confidence: 90%

“…The left jaws were embedded in paraffin, sectioned and stained with hematoxylin and eosin. The first molar mesial socket was chosen as it is one of the biggest of the three mandibular molars Histometric measurements based on standard stereological methods (15)(16)(17)(18)(19)(20) were performed using an image analysing system (KiJntron MOP AM 03) on tracings oblained from projections of the sections. Bone formation and bone resorption zones observed mi-croscopically were transferred to Ihe corresponding zones on Ihe tracings.…”

Section: Methodsmentioning

confidence: 99%

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Alveolar wound healing alteration under uranyl nitrate intoxication

1985

J Oral Pathology Medicine

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The deposit of uranium compounds in calcifying zones has been demonstrated in hone. Nevertheless, no studies on the effect of uranium on osteogenesis have been performed. A histologic and histometric study of the effect of a single intraperitoneal injection of 2 mg/kg of body weight of uranyl nitrate on bone formation is presented. It was performed on rats' healing sockets. 14 days after tooth extraction. The alveolar bone volume (15 × 105μm2 vs. 34 × 105μm2), total bone formation areas (4.85% vs. 19.55%). and volume density of bone in the alveolar apical third (0.26 vs. 0.40) were significantly lower in intoxicated animals than in the controls. These results indicate the inhibitory effect of uranyl nitrate on bone formation.

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Section: Discussionmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Alveolar wound healing alteration under uranyl nitrate intoxication

1985

J Oral Pathology Medicine

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“…The accuracy of the methodology used in this experiment has been repeatedly verified botb for the procedure of tooth extraction (5,8) and for the histometrie methods (5,(8)(9)(10)(11)(12), In the first case an atraumatic surgical technique was employed (5), whieh allows tooth extraction without post-operatory complications. The histometric methods are based on standard stereologic procedures and are employed to accurately assess bone aetivity (9, 10,12,14). This methodology was employed in the study of alveolar wound healing after X-radiation affording a numerical characterization ol such process (4,15).…”

Section: Discussionmentioning

confidence: 84%

Effect of diphosphonate on the prevention of X‐radiation‐induced inhibition of bone formation in rats

Ubios

Guglielmotti

Cabrini

1986

J Oral Pathology Medicine

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A histologic and histometric study of the effect of EHDP (ethane‐ 1–hydroxy‐1,1–diphosphonate) on the alveolar wound healing of irradiated animals is presented. This drug was selected based on its osteosclerotic effect when applied at low doses. The three left mandibular molars of 80 male Wistar rats were extracted. The rats were grouped into 4 sets of 20 rats each. Group I received no further treatment; Group II received daily intraperitoneal injections of EHDP (7.5 mg/Kg of body weight during 10 days); Group III: 15 Gy of X‐radiation were applied to the head; and Group IV were irradiated and injected with EHDP as were animals of Groups III and II. Half of the animals were killed after 14 days and the other half 30 days post‐extraction. Sections were made at the level of the mesial socket of the first molar in a buccolingual orientation, on which histometric determinations of bone activity were made. The results showed the attenuation of the inhibitory effect of radiation on bone formation when the animals were treated with EHDP.

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“…The present study suggests that active odontoclasts are highly susceptible to low doses of PTE resulting in an increase in the numbers of nuclei per cell. The extra nuclei could arise by mitotic division of existing nuclei but in osteociasts at least, replication of DNA does not occur (Parodi et al 1973). Alternatively they could arise by fusion of existing odontoclasts which would cause a reduction in total number of cells.…”

Section: Discussionmentioning

confidence: 99%

The effect of parathyroid hormone on the numbers of nuclei in feline odontoclasts in vivo

Addison

1980

J of Periodontal Research

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Odontoclasts exhibit varying numbers of nuclei. The purpose of the present study was to determine the effect of a low dose (4 USP units per 100 g. body weight) of parathyroid hormone extract (PTE) in vivo on the numbers of nuclei in whole feline odontoclasts. Odontoclasts were recovered in smear type preparations from the resorbing primary teeth of 12 kittens aged approximately 18 weeks. Four kittens had received PTE intravenously one hour prior to sacrifice, four six hours previously, and four were controls. The fresh smears were allowed to dry and subjected to dehydrogenase enzyme histochemical reactions. The unstained odontoclast nuclei contrasted with the stained cytoplasm and were counted at a magnification of × 125. The three groups had similar distribution patterns of nuclei per cell but progressive increases in the mean and median numbers of nuclei per cell were found following PTE treatment. The mean in control animals was 7.0 S.E. ± 0.12 and in the PTE 1 hour and PTE 6 hours groups was 8.0 S.E. ± 0.12 and 8.9 S.E. ± 0.12 respectively. The median values were 5.5, 6.6 and 7.3 respectively. The differences between both the control and PTE 1 hour, and between the PTE 1 hour and PTE 6 hours groups were statistically significant (p < 0.001). This rapid increase in the numbers of nuclei in odontoclasts after PTE treatment has not been reported previously.

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Total body irradiation effects on the bone resorption mechanism in rats subjected to orthodontic movements

Cited by 11 publications

References 6 publications

Alveolar wound healing alteration under uranyl nitrate intoxication

Alveolar wound healing alteration under uranyl nitrate intoxication

Effect of diphosphonate on the prevention of X‐radiation‐induced inhibition of bone formation in rats

The effect of parathyroid hormone on the numbers of nuclei in feline odontoclasts in vivo

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