Total Body Composition by DXA of 241 HIV-Negative Men and 162 HIV-Infected Men

Bonnet, É.; Delpierre, Cyrille; Sommet, Agnès; Marion-Latard, F.; Hervé, R.; Aquilina, C.; Labau, E.; Obadia, Martine; Marchou, B.; Massip, Patrice; Perret, Bertrand; Bernard, Jacques

doi:10.1385/jcd:8:3:287

Cited by 82 publications

(86 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Analysis of the results obtained in this study, however, further broadens our understanding of the metabolic effects of these two regimens, and helps to justify planning for further trials in an HIV-infected population. Also, correlations in metabolic disturbances between HIVinfected and uninfected individuals have been documented in other studies [28,29]. As would be expected, changes in most lipid and glucose parameters were generally comparable between the treatment groups during treatment with low-dose RTV alone.…”

Section: Discussionsupporting

confidence: 77%

Effects of ritonavir‐boosted darunavir vs. ritonavir‐boosted atazanavir on lipid and glucose parameters in HIV‐negative, healthy volunteers

Tomaka¹,

Lefebvre

Sekar³

et al. 2009

HIV Medicine

View full text Add to dashboard Cite

Background Darunavir (TMC114) is a new HIV protease inhibitor (PI). DesignThis Phase I, randomized, open-label trial compared the effects of darunavir plus low-dose ritonavir (RTV) (darunavir/RTV) with those of atazanavir/RTV on lipid and glucose parameters. MethodsForty-nine HIV-negative, healthy male volunteers received RTV 100 mg once a day (qd) for 7 days, followed by either darunavir/RTV 800/100 mg qd (n 5 25) or atazanavir/RTV 300/100 mg qd (n 5 24) for 21 days. Mean changes in fasting lipid and glucose parameters at day 28 were calculated using post-RTV alone (day 7) and baseline (day À 1) values as references. Short-term safety, tolerability and RTV pharmacokinetic parameters were evaluated. ResultsAfter 7 days of RTV treatment, the mean triglyceride concentration increased by approximately 30 mg/dL in both groups, changes in other lipid and glucose parameters were relatively small. Mean concentrations of lipids and glucose over the treatment period were mostly similar between the treatment groups. Mean changes from day 7 to day 28 for the darunavir/RTV and atazanavir/RTV groups, respectively, were À 3.6 and À 0.5 mg/dL for high-density lipoprotein cholesterol; 5.0 and 5.3 mg/dL for low-density lipoprotein cholesterol; 4.9 and 1.2 mg/dL for total cholesterol; 6.4 and 14.0 mg/dL for triglycerides; À 1.7 and À 2.4 mg/dL for glucose; and À 1.4 and 0.3 mg/dL for insulin. No grade 3 or 4 lipid or glucose laboratory abnormalities were reported. Treatmentemergent hyperbilirubinaemia was reported for all volunteers (including five grade 4 cases) during atazanavir/RTV treatment. ConclusionsCo-administration of darunavir or atazanavir with low-dose RTV resulted in minor and similar changes in lipid and glucose parameters in HIV-negative healthy volunteers. IntroductionThe introduction of HIV protease inhibitors (PIs) as part of highly active antiretroviral therapy (HAART) has drastically reduced the morbidity and mortality associated with HIV infection [1]. A new PI, darunavir (TMC114), has recently been shown to have considerable antiretroviral (ARV) activity in treatment-experienced patients. Darunavir boosted with low-dose ritonavir (RTV) (darunavir/RTV) led to significantly higher 24-and 48-week virological and immunological responses compared with currently available PIs in the POWER 1 and 2 (TMC114-C213 and TMC114-C202) studies in treatment-experienced HIVinfected patients, and was well tolerated [2][3][4].Given the need for lifelong antiretroviral therapy (ART), consideration of long-term toxicities is becoming increasingly important when choosing among different treatment regimens. It is therefore important to characterize the longterm tolerability profile of any new treatment, including DOI: 10.1111/j.1468-1293.00690.x HIV Medicine (2009 r 2009 British HIV Association 318 long-term metabolic abnormalities such as fat redistribution, dyslipidaemia, glucose intolerance and insulin resistance [5][6][7]. The association between ART and changes in lipid metabolism is well documented, particularly with PIs [...

show abstract

Section: Discussionsupporting

confidence: 77%

Effects of ritonavir‐boosted darunavir vs. ritonavir‐boosted atazanavir on lipid and glucose parameters in HIV‐negative, healthy volunteers

Tomaka¹,

Lefebvre

Sekar³

et al. 2009

HIV Medicine

View full text Add to dashboard Cite

show abstract

“…The BMI and WC were normal for sex and age. The DXA-derived total body fat percentage (median = 13.8%) was lower than in agematched HIV-negative Caucasian men but consistent with that observed previously in treated HIV-infected patients [9]. The median VAT area was 127 cm VAT vs. WC scatter plot …”

Section: Discussionsupporting

confidence: 87%

Surrogate markers of visceral adipose tissue in treated HIV‐infected patients: accuracy of waist circumference determination

et al. 2013

View full text Add to dashboard Cite

ObjectivesThe accuracy of the use of anthropometrics to quantify visceral adipose tissue (VAT) in treated HIV-infected patients is unknown. We evaluated the predictive accuracy of waist circumference (WC) with and without dual-energy X-ray absorptiometry (DXA)-derived trunk : limb fat ratio [fat mass ratio (FMR)] as surrogates for VAT determined using computerized axial tomography (CT-determined VAT). MethodsWe performed a retrospective cohort analysis of treated HIV-infected male patients followed at the Modena HIV Clinic. We developed prediction equations for VAT using linear regression analysis and Spearman correlations. Receiver operating characteristic (ROC) analysis evaluated the accuracy of WC alone or with FMR at discrete VAT thresholds. ResultsThe 1500 Caucasian male patients had a median age of 45 years, body mass index (BMI) of 24, WC of 87 cm, VAT area of 127 cm 2 and body fat percentage of 14%. The correlation between WC-predicted VAT and CT-VAT was 0.613, and this increased significantly if FMR was added. ConclusionsWC is a limited surrogate for CT-VAT in this population and DXA-derived parameters do not improve performance indices to a clinically relevant level. These findings should inform the applicability of WC to predict VAT in treated HIV-infected male patients.

show abstract

“…In the literature, the trunk/leg ratio (TLR) has been proposed as a marker of lipodystrophy in HIV patients [9,10], and it correlates with insulin resistance and dyslipidemia [5]. The FM of the trunk (FM-tr) and of the legs (FM-legs), and their ratio (TLR) can be considered in studying FM distribution changes occurring in disease and with aging.…”

Section: Introductionmentioning

confidence: 99%

Trunk and Lower Limb Fat Mass Evaluated by Dual-Energy X-Ray Absorptiometry in a 20- to 80-Year-Old Healthy Italian Population

Coin¹,

Ruggiero²,

Giannini

et al. 2012

Ann Nutr Metab

View full text Add to dashboard Cite

Background and Aims: Global fat mass distribution seems to correlate with different levels of cardio-metabolic risk; centrally distributed fat carries a high risk of cardiovascular disease, while lower limb adiposity may have a protective effect against insulin resistance. Reference data regarding body composition have already been published for the Italian population; the aim of this study was to add reference values for trunk and lower limb fat mass, and their ratio (TLR), developing percentile distributions for age brackets between 20 and 80 years. Methods: A retrospective analysis of a multicenter, cross-sectional study was conducted and 1,570 healthy Italian adults (1,241 females and 329 males) were selected. The regional fat mass, measured by dual-energy X-ray absorptiometry total body scan, was analyzed and the TLR was calculated. Results: In both genders we observed higher trunk fat mass values in older subjects against a smaller difference in BMI values. The leg fat mass was higher in old men, while it was similar in women at different ages. The TLR values in older subjects doubled those of younger subjects in both genders (62% in males and 71% in females). Conclusions: The identified ranges for trunk, leg fat mass, and TLR may be used as reference values to describe the global fat mass distribution in healthy individuals and to identify states of altered body fat distribution.

show abstract

Total Body Composition by DXA of 241 HIV-Negative Men and 162 HIV-Infected Men

Cited by 82 publications

References 28 publications

Effects of ritonavir‐boosted darunavir vs. ritonavir‐boosted atazanavir on lipid and glucose parameters in HIV‐negative, healthy volunteers

Effects of ritonavir‐boosted darunavir vs. ritonavir‐boosted atazanavir on lipid and glucose parameters in HIV‐negative, healthy volunteers

Surrogate markers of visceral adipose tissue in treated HIV‐infected patients: accuracy of waist circumference determination

Trunk and Lower Limb Fat Mass Evaluated by Dual-Energy X-Ray Absorptiometry in a 20- to 80-Year-Old Healthy Italian Population

Contact Info

Product

Resources

About