Total arsenic in urine: palladium-persulfate vs nickel as a matrix modifier for graphite furnace atomic absorption spectrophotometry

Nixon, David E.; Mussmann, G V; Eckdahl, Steven J.; Moyer, Thomas P.

doi:10.1093/clinchem/37.9.1575

Cited by 135 publications

(53 citation statements)

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“…Total urinary As concentration was measured in the Columbia University Trace Metals Core Laboratory by GFAA, using the Analyst 600 graphite furnace system, essentially as described (Nixon et al, 1991). This newer version of the GFAA system has a detection limit of 1 mg/l and therefore no ICP-MS analysis was required for urine samples.…”

Section: Laboratory Analysesmentioning

confidence: 99%

Health Effects of Arsenic Longitudinal Study (HEALS): Description of a multidisciplinary epidemiologic investigation

Ahsan

Chen

Parvez

et al. 2005

J Expo Sci Environ Epidemiol

264

300

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Health Effects of Arsenic Longitudinal Study (HEALS), a multidisciplinary and large prospective cohort study in Araihazar, Bangladesh, was established to evaluate the effects of full-dose range arsenic (As) exposure on various health outcomes, including premalignant and malignant skin tumors, total mortality, pregnancy outcomes, and children's cognitive development. In this paper, we provide descriptions of the study methods including study design, study population, data collection, response rates, and exposure and outcome assessments. We also present characteristics of the study participants including the distribution of exposure and the prevalence of skin lesion at baseline recruitment. A total of 11,746 married men and women between 18 and 75 years of age participated in the study at baseline (a response rate of 98%) and completed a full questionnaire interview that included a food frequency questionnaire, with a response rate of 98%. Among the 98% of the participants who completed the clinical evaluation, over 90% provided blood samples and spot urine samples. Higher educational status, male gender, and presence of premalignant skin lesions were associated with an increased likelihood of providing blood and urine samples. Older participants were less likely to donate a blood sample. About one-third of the participants consumed water from a well with As concentration in each of three groups: >100 microg/l, 25-100 microg/l, and <25 microg/l. Average urinary As concentrations were 140 and 136 microg/l for males and females, respectively. HEALS has several unique features, including a prospective study design, comprehensive assessments of both past and future changes in As exposure at the individual level, a large repository of biological samples, and a full dose range of As exposures in the study population. HEALS is a valuable resource for examining novel research questions on the health effects of As exposure.

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Section: Laboratory Analysesmentioning

confidence: 99%

Health Effects of Arsenic Longitudinal Study (HEALS): Description of a multidisciplinary epidemiologic investigation

Ahsan

Chen

Parvez

et al. 2005

J Expo Sci Environ Epidemiol

264

300

View full text Add to dashboard Cite

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“…This was done to attempt to increase participants' understanding of genetic susceptibility, as this community has low levels of formal education ( Table 1) Urine samples were collected at recruitment and follow-up visits. Arsenic concentrations were measured using graphite furnace atomic absorption (Perkin-Elmer Analyst 600 graphite furnace system) (limit of detection = 5 µg/L) at the Columbia University Trace Metal Core Laboratory [24,25]. For some newly recruited participants, follow-up arsenic measurements are not yet available.…”

Section: Methodsmentioning

confidence: 99%

Research Participants’ Attitudes towards Receiving Information on Genetic Susceptibility to Arsenic Toxicity in Rural Bangladesh

Tamayo¹,

Lin²,

Ahmed³

et al. 2020

Public Health Genomics

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Background: In human genetics research, it has become common practice for researchers to consider returning genetic information to participants who wish to receive it. Research participants in lower-resource settings may have barriers or competing interests that reduce the benefit or relevance of such information. Thus, the decision to return genetic information in these settings may involve special considerations of participants' interests and preferences. In this project, our goal was to assess Bangladeshi research participants' attitudes towards receiving information regarding genetic susceptibility to the effects of consuming arseniccontaminated drinking water, a serious environmental health concern in Bangladesh and other countries. Methods:We administered a short questionnaire to 200 individuals participating in the Health Effects of Arsenic Longitudinal Study. Associations between survey responses and participant characteristics were estimated using logistic regression. Results: Overall, 100% of our participants were inter-ested in receiving information regarding their genetic susceptibility to arsenic toxicities, and 91% indicated that being at increased genetic risk would motivate them to make efforts to reduce their exposure. Lower levels of education showed evidence of association with less concern regarding the health effects of arsenic and lower levels of motivation to reduce exposure in response to genetic information. Conclusions: Research participants in this low-resource setting appeared interested in receiving information on their genetic susceptibility to arsenic toxicity and motivated to reduce exposure in response to such information. Additional research is needed to understand how best to communicate genetic information in this population and to assess the impact of such information on individuals' behaviors and health.

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“…In each study, urinary arsenic was measured using graphite furnace atomic absorption spectrometry in a single laboratory (Nixon et al, 1991). Urinary arsenic was measured at the Trace Metals Core Laboratory at Columbia University, which is a member of the quality control program run by Institute de Sante Publique du Quebec and uses their quality control samples to standardize the measurements of urinary arsenic.…”

Section: Measurements Of Arsenic In Water and Urinementioning

confidence: 99%

Arsenic Exposure, Telomere Length, and Expression of Telomere-Related Genes among Bangladeshi Individuals

Pierce

Gao

Zhang

et al. 2014

ISEE Conference Abstracts

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Background-Inorganic arsenic is a carcinogen whose mode of action may involve telomere dysfunction. Recent epidemiological studies suggest that chronic arsenic exposure is associated with longer telomeres and altered expression of telomere-related genes in peripheral blood. In this study, we evaluated the association of urinary arsenic concentration with expression of telomererelated genes and telomere length in Bangladeshi individuals with a wide range of arsenic exposure through naturally contaminated drinking water.Methods-We used linear regression models to estimate associations between urinary arsenic and array-based expression measures for 69 telomere related genes using mononuclear cell RNA samples from 1,799 individuals. Association between arsenic exposure and a qPCR-based telomere length was assessed among 167 individuals.Results-Urinary arsenic was possitively associated with expression of WRN, and negatively associated with TERF2, DKC1, TERF2IP and OBFC1 (all P < 0.00035, Bonferroni correction threshold). We detected interaction between urinary arsenic and arsenic metabolism efficiency in relation to expression of WRN (P for interaction = 0.00008). In addition, we observed that very high arsenic exposure was associated with longer telomeres compared to very low exposure (P=0.02).Discussion-Our findings suggest that arsenic's carcinogenic mode of action may involve alteration of telomere maintenance and/or telomere damage. This study extends our knowledge regarding the effect of arsenic on telomere length and expression of telomere-related genes.

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Total arsenic in urine: palladium-persulfate vs nickel as a matrix modifier for graphite furnace atomic absorption spectrophotometry

Cited by 135 publications

References 0 publications

Health Effects of Arsenic Longitudinal Study (HEALS): Description of a multidisciplinary epidemiologic investigation

Health Effects of Arsenic Longitudinal Study (HEALS): Description of a multidisciplinary epidemiologic investigation

Research Participants’ Attitudes towards Receiving Information on Genetic Susceptibility to Arsenic Toxicity in Rural Bangladesh

Arsenic Exposure, Telomere Length, and Expression of Telomere-Related Genes among Bangladeshi Individuals

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