Total antioxidant status in lung cancer is associated with levels of endogenous antioxidants and disease stage rather than lifestyle factors – preliminary study

Zabłocka‐Słowińska, Katarzyna; Porębska, Irena; Gołecki, Marcin; Kosacka, Monika; Pawełczyk, Konrad; Pawlik-Sobecka, Lilla; Zarębska, Katarzyna; Grajeta, Halina

doi:10.5114/wo.2016.61850

Cited by 15 publications

(17 citation statements)

References 34 publications

(45 reference statements)

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“…In this study we demonstrated that lung cancer patients had significantly lower total antioxidant capacity compared to control subjects, regardless of circulating glucose concentrations, while parameters related directly to oxidative stress were increased only in patients with elevated glucose levels. However, in our previous study [ 5 ], similarly to this one ( S2 Table ), we found that depletion of the antioxidant defense system in lung cancer was not related to smoking status but rather disease progression. Therefore, we concluded that there are possible factors, other than smoking, which affect redox state in lung cancer.…”

Section: Discussionsupporting

confidence: 72%

“…In lung cancer, as well as in many other site-specific cancers, the redox status is altered and depletion of antioxidant capacity is observed along with tumor progression [ 1 – 5 ]. Several mechanisms may induce this perturbation, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…During lung cancer development and progression, alterations of glucose metabolism as well as depletion of total antioxidant capacity, show a deepening parallel. However, there have been no studies concerning the interactions between these two phenomena [ 5 , 19 , 20 ]. These alterations are unfavorable prognostic factors, finding potential relationships between them may enhance the management of lung cancer and create an opportunity for more personalized therapy, including the impact of these two alterations.…”

Section: Introductionmentioning

confidence: 99%

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Systemic redox status in lung cancer patients is related to altered glucose metabolism

et al. 2018

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Altered systemic redox status is often observed in lung cancer. However, detailed information on factors other, than smoking, which influence this perturbation is rather scarce. Elevated oxidative stress has been linked with disturbances in glucose metabolism before, but such associations have not been investigated in lung cancer. The aim of this study was to evaluate the relationship between systemic parameters of glucose metabolism and redox status in lung cancer patients (LC). Biochemical variables related to circulating glucose, i.e. glucose, insulin, c-peptide, fructosamine (FA), and glucose metabolism, i.e. β-hydroxybutyrate (BHB), lactate (LACT), non-esterified fatty acids (NEFAs), as well as redox status i.e. total antioxidant status (TAS) and total oxidant status (TOS) were determined for LC (n = 122) and control subjects (CS) (n = 84). HOMA-IR and the oxidative stress index (OSI) were calculated. LC patients had an altered redox status and glucose metabolism compared to CS. Positive correlations in LC were observed between TOS, OSI and circulating glucose as well as FA, while TAS positively correlated with BHB and NEFAs. In contrast, in metastatic LC, NEFAs and BHB positively correlated with OSI. Smoking status additionally stratified the observed relationships. In conclusion, we found that parameters related to circulating glucose or non-enzymatic glycation were correlated with oxidative stress (TOS and OSI), while metabolites such as BHB and NEFAs were correlated with antioxidant capacity (TAS). Metastasis prevalence and smoking seem to influence these correlations. However, the detailed mechanism of this relationship requires further research, in particular as regards the surprising positive correlation between NEFAs and TAS.

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systemic redox status in lung cancer patients is related to altered glucose metabolism

et al. 2018

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“…In a study by Zabłocka-Słowińska et. al, uric acid level was found to be lower in smokers than in non-smokers (23). Further research is needed in primary care to determine if there is a clinically useful role of serum uric acid levels in risk stratification.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of Changes in The Hematological Parameters, Lipid Profile and Depressive Symptoms Before and After Smoking Cessation Treatment

Dağıstan¹,

Kutlu²

2019

J Basic Clin Health Sci

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Introduction: Tobacco dependence is a cluster of behavioural, cognitive, and physiological phenomena. We aimed to investigate the changes in the hematological parameters, lipid profile and depressive symptoms before and after smoking cessation. Methods: In this intervention study, 150 cases admitted to the clinic to quit smoking and stopped smoking for at least three months were investigated. All participants have received motivational interview and appropriate medical treatment (varenicline, bupropion, nicotine replacement therapy). We designed the study to evaluate the effects of cigarette smoking on some biochemical markers and depressive symptoms. Results: Motivational interviews were conducted on all participants, and 68,7% (n = 103) were treated with varenicline, 19,3% (n=29) with bupropion and 12% (n=18) with nicotine replacement therapy (NRT). There was a statistically significant relationship between the treatment method and the smoking cessation duration (p=0.002). Cessation period was longer in the group using varenicline. After quitting smoking, the Beck Depression Scores (BDS) decreased significantly (p<0.001). In cases with smoking duration between 3-6 months, the levels of carbon monoxide (CO) (p<0.001), white blood count (WBC) (p<0.001), hematocrit (p=0.003), hemoglobin (Hb) (p=0.002) and mean corpuscular volume (MCV) (p<0.001) decreased significantly. Conclusions: In our study, positive changes were observed in hematologic, biochemical parameters and depressive symptoms after quitting smoking. So, it is important that the society should be informed about the dangers of smoking. In particular, primary health care physicians should ask each patient whether they smoke or not, and encourage to quit smoking.

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“…It has been confirmed that antioxidant/oxidant status changes in lung cancer, as well as in many other site-specific cancers, and a depletion of antioxidant capacity has been observed along with tumor progression. 27 Despite this, the mechanisms of redox disturbance in lung cancer patients are still not entirely clear. Cigarette smoking and lung inflammation, as well as systemic inflammation, are recognized as major causes of depletion of antioxidant Differences were assessed using the Mann-Whitney U test or Student's t-test between sex-related groups of lung cancer patients and control subjects; p < 0.05 (observed significant differences between compared groups are in bold); LW -lung cancer women; CW -control women; LM -lung cancer men; CM -control men; BMI -body mass index; FFMI -fat-free mass index; BFP -body fat percentage; WC -waist circumference; HC -hip circumference; WHR -waist-to-hip ratio; CC -calf circumference; MAC -mid-arm circumference.…”

Section: Discussionmentioning

confidence: 99%

The relationships between glycemic index and glycemic load of diets and nutritional status and antioxidant/oxidant status in the serum of patients with lung cancer

Zabłocka‐Słowińska¹,

Skórska²,

Płaczkowska³

et al. 2019

Adv Clin Exp Med

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Zabłocka-Słowińska KA, Skórska K, Płaczkowska S, et al. The relationships between glycemic index and glycemic load of diets and nutritional status and antioxidant/oxidant status in the serum of patients with lung cancer. Abstract Background.A low glycemic index (GI) and glycemic load (GL) of diets as well as proper nutritional status may partially slow down depletion in antioxidant capacity, and may therefore have an impact on antioxidant/ oxidant status in lung cancer patients. However, no studies concerning these associations had previously been conducted.Objectives. The aim of this study was to investigate the association between GI or GL and nutritional status and antioxidant/oxidant status in lung cancer patients.Material and methods. The study was conducted among 180 lung cancer patients (82 women and 98 men) and 171 control subjects (78 women and 93 men). Exclusion criteria for the control subjects included cancers, pro-inflammatory conditions, brain diseases, and psychiatric disorders. All participants were evaluated in terms of their systemic antioxidant/oxidant status, nutritional status (anthropometric parameters), dietary GI and GL and parameters related to circulating glucose: fasting glucose, insulin level and homeostasis model assessment for insulin resistance (HOMA-IR). Results.In women who were lung cancer-positive, associations were observed between total antioxidant status (TAS) and parameters of nutritional status, and between oxidative stress index (OSI) and fasting glucose. In men with lung cancer, we found a positive correlation between total oxidant status (TOS) and GI. In the control group of women, TAS positively correlated with anthropometric parameters, but negatively with dietary fiber and total carbohydrate content. Additionally, TOS and OSI negatively correlated with parameters related to body weight and positively with insulin. In control men, we observed significant negative correlations between parameters related to fasting glucose and TAS and positive ones with TOS and OSI. Conclusions.The results show that in lung cancer oxidative stress is related to GI, while TAS is related to nutritional status. Further investigations performed on a larger cohort are required to better clarify the observed relationships as well as to explain the potential mechanisms involved.

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Total antioxidant status in lung cancer is associated with levels of endogenous antioxidants and disease stage rather than lifestyle factors – preliminary study

Cited by 15 publications

References 34 publications

Systemic redox status in lung cancer patients is related to altered glucose metabolism

Systemic redox status in lung cancer patients is related to altered glucose metabolism

Evaluation of Changes in The Hematological Parameters, Lipid Profile and Depressive Symptoms Before and After Smoking Cessation Treatment

The relationships between glycemic index and glycemic load of diets and nutritional status and antioxidant/oxidant status in the serum of patients with lung cancer

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