Total and differential white blood cell counts predict eight-year incident coronary heart disease in elderly Japanese-American men: The Honolulu Heart Program

Karino, Shigehiko; Willcox, Bradley J.; Fong, Ka-On; Lo, Serena C.; Abbott, Robert D.; Masaki, Kamal

doi:10.1016/j.atherosclerosis.2014.12.003

Cited by 25 publications

(22 citation statements)

References 29 publications

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“…As far most people one or more risk factors for CHD or a metabolic syndrome cluster are present, it may not be wise to take a just associated components into account. Although the number of white blood cells still is one of the most common tests used to diagnose disease, it seems we should start to consider it as a good predictor of a disease as well [25,26]. Investigation of its association with platelet count revealed a statistically significant correlation between BMI and waist circumference with indices of platelet count.…”

Section: Discussionmentioning

confidence: 99%

Association Between Obesity, White Blood Cell and Platelet Count

Jamshidi

Seif

2017

Zahedan J Res Med Sci

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Background: Cardiovascular disease is resulted from malfunctioning's of heart as well as blood vessels. More than two decades ago it was noted that the number of white blood cells can be an indicated of the existence of such disease. Platelet activation and aggregation are among the include processes. That are considered in pathophysiology of a coronary heart disease. However there seems to be a paucity of research on platelet count in patients suffering from obesity. Moreover although previous studies have indicated a positive correlation between platelet and white blood cells. Counts and mortality from coronary heath disease, how this might correlate with obesity is an issue still in need of more attention. Objectives: The present study was designed to evaluate platelet count and white blood cell count in those patients who suffer from obesity as compared with control subjects who were not obese. Methods: In this cross-sectional study, there were a total of 1024 Iranian subjects living in Hamedan include, staff of Islamic Azad University of Hamedan and subjects who referred to Ekbatan hospital in Hamedan during the period of 6 months randomly and staff of Islamic Azad University of Hamedan. The absence of infectious disease was confirmed by a general practitioner. Finally, the samples included 486 subjects, 254 male, and 232were females. Body mass index was calculated. Waist circumference in the Iranian subjects, at least in men 89 (cm) and women 91 (cm) was considered. White blood cell and platelet count was measured. T-test and Pearson's correlation were run to analyze the collected data through SPSS software version 16.

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Section: Discussionmentioning

confidence: 99%

Association Between Obesity, White Blood Cell and Platelet Count

Jamshidi

Seif

2017

Zahedan J Res Med Sci

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“…The role of inflammation and inflammatory cells in cardiovascular disease has been demonstrated in countless studies, showing that leukocyte 1 , monocyte 2 , neutrophil counts 3 and ratios hereof 4 are related to coronary artery disease (CAD) severity and outcome. The monocyte-to-lymphocyte ratio (MLR) has recently been introduced as a potent predictor of mortality among coronary angiography (CAG)…”

Section: Introductionmentioning

confidence: 99%

Effect of Monocyte-to-Lymphocyte Ratio on Heart Failure Characteristics and Hospitalizations in a Coronary Angiography Cohort

Gijsberts

Ellenbroek

Berg

et al. 2017

The American Journal of Cardiology

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Inflammation is a shared mechanism in coronary artery disease (CAD) and subsequent heart failure (HF) and circulating monocyte and lymphocyte counts predict CAD severity and outcomes. We investigated whether the monocyte-to-lymphocyte ratio (MLR) correlates with biomarkers of HF and extent of CAD, as well as future HF hospitalizations in patients undergoing coronary angiography (CAG). Therefore, we studied 1754 patients undergoing CAG for stable CAD, unstable angina or myocardial infarction (MI).MLR was determined at blood draw prior to angiography and related cross-sectionally to HF biomarkers

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“…Monocyte count also emerges to be an independent risk factor for atherosclerotic diseases. However, some epidemiologic and prospective cohort studies indicated that monocytosis was not associated with CHD [49], cardiovascular death [50] or stroke [51]. Moreover, increased circulating monocyte count was correlated with good coronary collateral growth in patients with severely stenotic CAD [52] and with diabetes [53].…”

Section: Resultsmentioning

confidence: 99%

Potential of Monocyte Count for the Assessment of Cardiovascular Disease

Matsumura¹,

Yamamoto²,

Tsujita³

et al. 2017

Cardiovasc Pharm Open Access

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Atherosclerosis is a chronic inflammatory disease proceeding from an imbalance in lipid metabolism and immune responses. Since leukocytes, especially monocytes and monocyte-derived macrophages, play pivotal roles in the progression of atherosclerosis, it is possible that monocyte count is a beneficial marker for predicting cardiovascular disease (CVD). Many epidemiologic and clinical studies have indicated monocytosis to be an independent predictor of cardiovascular events, both in healthy individuals at baseline and in patients with CVD or with high risk diseases for CVD, such as diabetes, dyslipidemia, hypertension and chronic kidney disease. This relationship has been observed in prospective and retrospective cohort studies, and endures after adjustment for several CVD risk factors. Other indicators utilized monocyte count, such as lymphocyte-to-monocyte ratio, monocyte-to-lymphocyte ratio and monocyte-to-high-density lipoprotein cholesterol ratio, were also independently associated with cardiovascular events and its mortality. In this review, we discussed the clinical utility of the monocyte count as a predictive marker in atherosclerotic diseases.

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Total and differential white blood cell counts predict eight-year incident coronary heart disease in elderly Japanese-American men: The Honolulu Heart Program

Cited by 25 publications

References 29 publications

Association Between Obesity, White Blood Cell and Platelet Count

Association Between Obesity, White Blood Cell and Platelet Count

Effect of Monocyte-to-Lymphocyte Ratio on Heart Failure Characteristics and Hospitalizations in a Coronary Angiography Cohort

Potential of Monocyte Count for the Assessment of Cardiovascular Disease

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