Torsion of autotransplanted splenic tissue in Gaucher disease

Ando, Kunimasu; Miyano, Takeshi; Yamataka, Atsuyuki; Lane, Geoffrey J.; Kobayashi, Hiroyuki; Shimizu, Toshiaki; Yamashiro, Yuichiro

doi:10.1016/s0022-3468(97)90023-3

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…9 Autogenous grafting of the spleen has been shown to be a viable procedure. Scintigraphic studies have revealed the presence of captive tissue in autotransplanted fragments, 1,10,11 and histopathologic analysis has shown that the architecture of the autograft is similar to that of normal spleen. [12][13][14][15][16][17][18] In addition, preservation of its phagocytic capacity and the absence of Howell-Jolly corpuscles in peripheral blood have been described after autotransplantation of the spleen.…”

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confidence: 99%

Antibody Response of Autogenous Splenic Tissue Implanted in the Abdominal Cavity of Mice

et al. 2005

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There is still controversy about the immunologic function of autotransplanted splenic tissue. In this study, splenic autotransplantation was performed in the abdominal cavity of mice, and the plaqueforming cell (PFC) assay was used to investigate the frequency of antibody-forming cells in response to sheep red blood cell (SRBC) immunization. BALB/c mice were divided into four groups according to the location of the autogenous graft: intraomental (IO), free peritoneal splenosis (FPS), retroperitoneal (RP), and nongrafted control (CT). Thirty days after surgery the mice were immunized intraperitoneally with SRBCs, and 4 days later splenic immunoglobulin M anti-SRBC-secreting cells were determined by counting the number of PFCs. All the immunized mice showed increased numbers of PFCs that were about 2 logs higher than those in the the nonimmunized controls (P < 0.005). The frequencies of anti-SRBC-producing cells in the tissues grafted in various sites of the abdominal cavity (IO, FPS, RP), in the normal spleen from nonoperated controls (CT), or in the sham-operated control group (SCT) were not notably different (5582 -2475 PFC/10 7 cells for IO; 4849 -1856 for FPS; 6604 -2903 for RP; 5940 -5029 for CT; and 6172 -2203 for SCT). Similar histology with small architectural variations was observed in all implants; less white pulp was involved, and there was more congestion in the red pulp, with extensive sinusoids and reticular fiber proliferation. This study shows that the T cell-dependent antibody response in implanted splenic tissues is as efficient as in the intact spleen, with no difference between the graft sites studied. This immune response does not depend on the slight architectural variations observed in the splenic implants.T he importance of the splenic autotransplant technique is justified by the high incidence of total splenectomy, the spleen being the most affected organ during blunt trauma as well as highly susceptible to iatrogenic incidents. 1,2 Since the nineteenth century splenectomy has been the treatment advised after splenic trauma, although current studies indicate that this procedure is not exempt from complications.

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confidence: 99%

Antibody Response of Autogenous Splenic Tissue Implanted in the Abdominal Cavity of Mice

et al. 2005

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“… 9 In the present case, we transplanted six pieces of splenic tissue, weighing a total of 50 g. Because torsion of autotransplanted splenic tissue has been reported as a rare complication, careful observations will be necessary in this case. 15 …”

Section: Discussionmentioning

confidence: 99%

Single-Incision Laparoscopic Splenectomy and Splenic Autotransplantation for an Enlarged Wandering Spleen with Torsion

Katsura

Kawamura

Harada

et al. 2013

Eur Jnl Ped Surg Reports

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A wandering spleen is a rare condition in which the spleen is not located in the left upper quadrant, but instead is found in the lower abdomen or in the pelvic region because of the laxity of the peritoneal attachments. The unusually long pedicle is susceptible to twisting, which can lead to ischemia, and eventually to necrosis. We herein report a case of an enlarged wandering spleen with torsion, successfully treated by single-incision laparoscopic splenectomy and autotransplantation. The transplanted splenic tissues could be identified on a spleen scintigram obtained 3 months after the surgery. Howell-Jolly bodies were not observed in blood specimens. This procedure is able to prevent an overwhelming postsplenectomy infection, and leads to satisfactory cosmetic results.

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“…Estudos prévios mostraram que, apesar desse procedimento ser quase isento de complicações pós-operatórias, o pequeno número de implantes realizados pela maioria dos cirurgiões era insuficiente para evidenciar a sua função. 32,35,37,42,51,59 Por outro lado, trabalhos experimentais foram unânimes em encontrar menor incidência e intensidade de sepse em animais submetidos ao auto-implante, quando comparados com os asplênicos. 34,38,40,41,44,45 Atualmente, acredita-se que os resultados não favoráveis descritos na literatura decorrem principalmente da quantidade insuficiente de tecido esplênico implantado e que, apesar de sua função estar presente, ela não pode ser detectada.…”

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Cirurgias conservadoras do baço para tratamento da doença de Gaucher

Petroianu¹

2004

Rev. Bras. Hematol. Hemoter.

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As complicações da esplenomegalia na doença de Gaucher, com IntroduçãoEsta afecção, descrita por Gaucher (1882) como epitelioma primitivo do baço, consiste em uma desordem metabólica familiar, com característica autossômica dominante. Ela é uma dislipidemia dos esfingolípides provocada por atividade defeituosa da enzima ácido β-glicosidase e tem como conseqüência o acúmulo de seu substrato, o glicocerebrosídeo ceramida glicosil, nos lisossomas das células do sistema mononuclear fagocitário, transformando-as nas células de Gaucher. Em decorrência dessa infiltração gordurosa, o fígado e, principalmente, o baço, que Artigo Original -cirurgia conservadora do baço.p65

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Torsion of autotransplanted splenic tissue in Gaucher disease

Cited by 4 publications

References 9 publications

Antibody Response of Autogenous Splenic Tissue Implanted in the Abdominal Cavity of Mice

Antibody Response of Autogenous Splenic Tissue Implanted in the Abdominal Cavity of Mice

Single-Incision Laparoscopic Splenectomy and Splenic Autotransplantation for an Enlarged Wandering Spleen with Torsion

Cirurgias conservadoras do baço para tratamento da doença de Gaucher

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