Torque-Teno virus viral load as a potential endogenous marker of immune function in solid organ transplantation

Torque teno virus for risk stratification of graft rejection and infection in kidney transplant recipients—A prospective observational trial

“…15 Peripheral blood TTV copy numbers might mirror the intensity of host immunosuppression. 16 TTV load was shown to associate with the amount and type of immunosuppressive drugs administered to solid organ recipients and is thus indirectly associated with allograft rejection and infectious disease. 8,15,[17][18][19][20][21][22][23][24][25][26][27] In kidney transplant recipients, recent data suggest a potential of TTV quantification for risk prediction of infectious events 23,25 and graft rejection.…”

Early kinetics of Torque Teno virus DNA load and BK polyomavirus viremia after kidney transplantation

“…To the Editor, Growing evidence supports the role of the replication kinetics of Torque Teno virus (TTV) as a convenient surrogate marker of immunosuppression after solid organ transplantation. 1,2 Human BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) constitutes one of the leading causes of graft lost after kidney transplantation (KT), a circumstance that has prompted the search for improved risk stratification strategies. 3 Since the host's control of both TTV and BKPyV infection mainly relies on the cell-mediated immunity, it could be hypothesized that the presence of high TTV DNA levels could identify those recipients at greatest risk of BKPyVAN.…”

“…3 Since the host's control of both TTV and BKPyV infection mainly relies on the cell-mediated immunity, it could be hypothesized that the presence of high TTV DNA levels could identify those recipients at greatest risk of BKPyVAN. 1,4 However, contradictory results on this issue have been recently reported. 5 In a previous study by our group, we prospectively assembled a single-center cohort of KT recipients in which plasma TTV DNA load was quantified at baseline and regularly through the first 12 months.…”

Current Views of Torque Teno Virus (TTV) in Liver Diseases

“…ТТ-вирусные частицы имеют сферическую форму, лишены наружной оболочки, имеют размер от 30 до 50 нм [9]. Геном torque teno virus представлен безоболочечной одноцепочечной кольцевидной ДНК с отрицательной полярностью [3,10,11], протяженностью 3,8 kb и содержит 3739 спаренных оснований [5,8,12]. Плавучая плотность TTV в градиенте хлорида цезия составляет 1,31-1,34 г/см 3 [10].…”

“…Белок ORF2 является белком-супрессором провоспалительных цитокинов (ИЛ-6, ИЛ-8, ЦОГ 2) и транскрипционного фактора NF-kappa-B (NF-κB). Белок ORF3 играет важную роль в клеточном цикле и синтезе апоптоз-индуцирующего белка (TAIP), что препятствует реализации противовирусной защиты организма-хозяина [12,13,28].…”