Torque teno virus for risk stratification of graft rejection and infection in kidney transplant recipients—A prospective observational trial

Abstract

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Torque Teno virus load as a surrogate marker for the net state of immunosuppression: The beneficial side of the virome

“…Interestingly, the largest effect size was obtained for BK infection, CMV disease, and infections restricted to opportunistic pathogens, supporting the notion that TTV replication control is mainly exerted by the T cell–mediated immunity. Moreover, both associations were consistent across a set of sensitivity analyses 7 . In addition to its single‐center design (a critical point considering the lack of international standards for TTV PCR assays), some limitations must be noted.…”

Torque Teno Virus Viral Load as a Marker of Immune Function in Allogeneic Haematopoietic Stem Cell Transplantation Recipients

“…In summary, we found an inverse correlation between the TTV viral load and T-cell function, independently of the count of T-cells. The evaluation of immune competency, for at-risk populations, using the monitoring of TTV viraemia, requires further assessment, as currently under evaluation in kidney transplant recipients [ 32 ]. Indeed, during the dynamic process of immune reconstitution post-transplant, a pivotal period for allo-HSCT recipients, a rapid and individual assessment of the immune system’s capacities could be of clinical interest to adapt anti-infectious prophylactic treatments, to guide the immunosuppressant treatment and in fine prevent graft rejection GvHD, infectious events and relapsing disease, which are the main causes of morbimortality in this population.…”

Seroprevalence of Torque Teno Virus in hemodialysis and renal transplant patients in Australia: A cross‐sectional study

“…Several previous studies have assessed the role of TTV viral load monitoring in renal transplantation, either retrospectively, [17][18][19]24 or more recently prospectively. 19,25,26 We propose that next step should be a large international multicentre prospective cohort study with patient-centered endpoints. The current study suggests that TTV viral load has potential as a biomarker to tailor immunosuppression in renal transplantation in Australia as elsewhere, but the results of larger prospective observational and interventional studies are needed before it enters clinical practice.…”

“…The current study is only one piece of the puzzle needed to assess the potential utility of TTV in tailoring immunosuppression in renal transplantation. Several previous studies have assessed the role of TTV viral load monitoring in renal transplantation, either retrospectively, 17‐19,24 or more recently prospectively 19,25,26 . We propose that next step should be a large international multicentre prospective cohort study with patient‐centered endpoints.…”