Torilin ameliorates type II collagen-induced arthritis in mouse model of rheumatoid arthritis

Endale, Mehari; Lee, Whi Min; Kwak, Youn‐Sig; Kim, Nami; Kim, Bok-Kyu; Kim, Seung-Hyung; Cho, JaeYoul; Kim, Suk; Park, Seung-Chun; Yun, Bong‐Sik; Ko, Dukhwan; Rhee, Man Hee

doi:10.1016/j.intimp.2013.04.012

Cited by 27 publications

(21 citation statements)

References 27 publications

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“…12 Moreover, BlyS regulates the activation and response of T cells, the over-expression of which may destroy the equilibria of cell production and autoimmune tolerance, thus triggering many types of autoimmune diseases. 13 In this study, the BlyS levels of the two groups were significantly different, suggesting that the expressions of B-lymphocytes in RA patients were evidently disordered.…”

Section: Discussionmentioning

confidence: 51%

Effects of B-lymphocyte dysfunction on the serum copper, selenium and zinc levels of rheumatoid arthritis patients

Li¹,

Liang²,

He-juan³

et al. 2014

Pak J Med Sci

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Objective: To study the effects of B-lymphocyte dysfunction on the serum copper, selenium and zinc levels of rheumatoid arthritis (RA) patients, and to provide evidence for clinical practice. Methods: Sixty RA patients enrolled in our hospital from August 2009 to August 2013 were selected as the observation group. Another 60 healthy subjects who received physical examinations in our hospital were selected as the control group. Their B-lymphocyte stimulator (BlyS) levels and CD19+CD25+ lymphocyte percentages were determined. The levels of trace elements were measured, and correlation analysis was performed. Results: The BlyS levels of the observation group and the control group were (0.39±0.21) ng/ml and (0.13±0.04) ng/ml respectively, which were significantly different (P<0.05). The percentages of CD25+, CD19+ and CD19+CD25+ lymphocytes in the observation group were significantly higher than those in the control group (P<0.05). The serum copper, selenium and zinc levels of the observation group were significantly lower than those of the control group (P<0.05). Pearson's correlation analysis showed that the BlyS level was correlated with the levels of copper, selenium and zinc respectively (r=-0.541, -0.370, -0.430, P<0.05). Conclusion: Rheumatoid Arthritis may be induced by BlyS-mediated B-lymphocyte dysplasia and dysfunction, accompanied by decreased expressions of copper, selenium and zinc.

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Section: Discussionmentioning

confidence: 51%

Effects of B-lymphocyte dysfunction on the serum copper, selenium and zinc levels of rheumatoid arthritis patients

Li¹,

Liang²,

He-juan³

et al. 2014

Pak J Med Sci

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“…In a few cases, it rarely leads to pulmonary fibrosis. 10 MTX can be administered intraperitoneally at 0.01 mL/g in 7% sodium bicarbonate, 11 intraperitoneal injections (1 mL) (0.05-0.5 mg/kg) in normal saline (0.9%), 12 intramuscularly at 0.3 mg/kg twice a week, 13 by oral gavage at 0.2 mg/kg/day, 14 or mixed with powdered food at 0.2 mg/kg/day. 15 Tofacitinib has been proven to be functionally, clinically, and radiographically more effective than MTX in treating patients with RA.…”

Section: Available Treatments For Arthritismentioning

confidence: 99%

Molecular targets in arthritis and recent trends in nanotherapy

Roy¹,

Kanwar²,

Kanwar³

2015

IJN

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Due to its severity and increasing epidemiology, arthritis needs no description. There are various forms of arthritis most of which are disabling, very painful, and common. In spite of breakthroughs in the field of drug discovery, there is no cure for arthritis that can eliminate the disease permanently and ease the pain. The present review focuses on some of the most successful drugs in arthritis therapy and their side effects. Potential new targets in arthritis therapy such as interleukin-1β, interleukin-17A, tumor necrosis factor alpha, osteopontin, and several others have been discussed here, which can lead to refinement of current therapeutic modalities. Mechanisms for different forms of arthritis have been discussed along with the molecules that act as potential biomarkers for arthritis. Due to the difficulty in monitoring the disease progression to detect the advanced manifestations of the diseases, drug-induced cytotoxicity, and problems with drug delivery; nanoparticle therapy has gained the attention of the researchers. The unique properties of nanoparticles make them highly attractive for the design of novel therapeutics or diagnostic agents for arthritis. The review also focuses on the recent trends in nanoformulation development used for arthritis therapy. This review is, therefore, important because it describes the relevance and need for more arthritis research, it brings forth a critical discussion of successful drugs in arthritis and analyses the key molecular targets. The review also identifies several knowledge gaps in the published research so far along with the proposal of new ideas and future directions in arthritis therapy.

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“…All other chemicals were purchased from Sigma-Aldrich (St. Louis, MO) unless otherwise stated. Torilin (98%) was prepared as previously indicated in [26] and dissolved in dimethyl sulfoxide and freshly diluted in culture media for all experiments.…”

Section: Methodsmentioning

confidence: 99%

“…Since torilin has been shown to possess anti-inflammatory activities in vitro and in vivo [24, 25], we previously have reported that torilin modifies inflammatory cell and cytokine imbalances with the attenuation of the severity of arthritis in mouse model of rheumatoid arthritis [26]. However, its molecular mechanism of action against inflammatory responses has not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

Torilin Inhibits Inflammation by Limiting TAK1-Mediated MAP Kinase and NF-κB Activation

Endale

Kim

Kwak

et al. 2017

Mediators of Inflammation

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Torilin, a sesquiterpene isolated from the fruits of Torilis japonica, has shown antimicrobial, anticancer, and anti-inflammatory properties. However, data on the mechanism of torilin action against inflammation is limited. This study aimed at determining the anti-inflammatory property of torilin in LPS-induced inflammation using in vitro model of inflammation. We examined torilin's effect on expression levels of inflammatory mediators and cytokines in LPS-stimulated RAW 264.7 macrophages. The involvement of NF-kB and AP-1, MAP kinases, and adaptor proteins were assessed. Torilin strongly inhibited LPS-induced NO release, iNOS, PGE2, COX-2, NF-α, IL-1β, IL-6, and GM-CSF gene and protein expressions. In addition, MAPKs were also suppressed by torilin pretreatment. Involvement of ERK1/2, P38MAPK, and JNK1/2 was further confirmed by PD98059, SB203580, and SP600125 mediated suppression of iNOS and COX-2 proteins. Furthermore, torilin attenuated NF-kB and AP-1 translocation, DNA binding, and reporter gene transcription. Interestingly, torilin inhibited TAK1 kinase activation with the subsequent suppression of MAPK-mediated JNK, p38, ERK1/2, and AP-1 (ATF-2 and c-jun) activation and IKK-mediated I-κBα degradation, p65/p50 activation, and translocation. Together, the results revealed the suppression of NF-κB and AP-1 regulated inflammatory mediator and cytokine expressions, suggesting the test compound's potential as a candidate anti-inflammatory agent.

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Torilin ameliorates type II collagen-induced arthritis in mouse model of rheumatoid arthritis

Cited by 27 publications

References 27 publications

Effects of B-lymphocyte dysfunction on the serum copper, selenium and zinc levels of rheumatoid arthritis patients

Effects of B-lymphocyte dysfunction on the serum copper, selenium and zinc levels of rheumatoid arthritis patients

Molecular targets in arthritis and recent trends in nanotherapy

Torilin Inhibits Inflammation by Limiting TAK1-Mediated MAP Kinase and NF-κB Activation

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Torilin ameliorates type II collagen-induced arthritis in mouse model of rheumatoid arthritis

Cited by 27 publications

References 27 publications

Effects of B-lymphocyte dysfunction on the serum copper, selenium and zinc levels of rheumatoid arthritis patients

Effects of B-lymphocyte dysfunction on the serum copper, selenium and zinc levels of rheumatoid arthritis patients

Molecular targets in arthritis and recent trends in&nbsp;nanotherapy

Torilin Inhibits Inflammation by Limiting TAK1-Mediated MAP Kinase and NF-κB Activation

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Molecular targets in arthritis and recent trends in nanotherapy