Topology Optimization to Reduce the Stress Shielding Effect for Orthopedic Applications

Al-Tamimi, Abdulsalam Abdulaziz; Peach, Ceri; Fernandes, Paulo R.; Cseke, Akos; Bartolo, Paulo Jorge Da Silva

doi:10.1016/j.procir.2017.04.032

Cited by 65 publications

(33 citation statements)

References 16 publications

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“…1, 2). Peri-fracture bone resorption and demineralization of cortical bone have also been previously reported in preclinical and clinical studies and were associated with stiff fixation leading to stress shielding of the bone 25,26 . Our recently developed time-lapsed in vivo micro-CT monitoring approach therefore allowed to precisely characterize the spatio-temporal changes in structural and dynamic callus parameters preceding non-unions.…”

Section: Discussionmentioning

confidence: 59%

Spatio-temporal characterization of fracture healing patterns and assessment of biomaterials by time-lapsed in vivo micro-computed tomography

Wehrle

Betts

Kuhn

et al. 2021

Sci Rep

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Thorough preclinical evaluation of functionalized biomaterials for treatment of large bone defects is essential prior to clinical application. Using in vivo micro-computed tomography (micro-CT) and mouse femoral defect models with different defect sizes, we were able to detect spatio-temporal healing patterns indicative of physiological and impaired healing in three defect sub-volumes and the adjacent cortex. The time-lapsed in vivo micro-CT-based approach was then applied to evaluate the bone regeneration potential of functionalized biomaterials using collagen and bone morphogenetic protein (BMP-2). Both collagen and BMP-2 treatment led to distinct changes in bone turnover in the different healing phases. Despite increased periosteal bone formation, 87.5% of the defects treated with collagen scaffolds resulted in non-unions. Additional BMP-2 application significantly accelerated the healing process and increased the union rate to 100%. This study further shows potential of time-lapsed in vivo micro-CT for capturing spatio-temporal deviations preceding non-union formation and how this can be prevented by application of functionalized biomaterials. This study therefore supports the application of longitudinal in vivo micro-CT for discrimination of normal and disturbed healing patterns and for the spatio-temporal characterization of the bone regeneration capacity of functionalized biomaterials.

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Section: Discussionmentioning

confidence: 59%

Spatio-temporal characterization of fracture healing patterns and assessment of biomaterials by time-lapsed in vivo micro-computed tomography

Wehrle

Betts

Kuhn

et al. 2021

Sci Rep

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“…In particular, the porous properties, which are closely related to the structure and function of the scaffold, were considered to be the most important factor in manufacturing bone scaffolds [9,10]. On the other hand, stress shielding occurs owing to differences in the mechanical properties between bone scaffolds and the surrounding tissue [11,12]. Hence, it is also important that bone scaffolds be designed to have mechanical properties similar to those of cancellous bone.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Structural and Mechanical Properties of Porous Artificial Bone Scaffolds Fabricated via Advanced TBA-Based Freeze-Gel Casting Technique

Kim

Goh

et al. 2019

Applied Sciences

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Porous hydroxyapatite (HA) artificial bone scaffolds were prepared via the freeze-gel casting process in order to improve their mechanical strengths. As a porogen, various volumes of poly (methyl methacrylate) (PMMA) powders were added to obtain high porosity, such as in cancellous bone. After fabrication, the porous and mechanical properties of the scaffolds were examined. The HA60 scaffold, with a porosity over 80%, had proper compressive strength and modulus and satisfied the range of properties of cancellous bone. Moreover, it was found that the investigated mechanical properties were affected by the scaffolds’ porosity. However, a section was found where the compressive strength was high despite the increase in the porosity. Specifically, HA30 had a porosity of 62.9% and a compressive strength of 1.73 MPa, whereas the values for HA60 were 81.9% and 3.23 MPa, respectively. The results indicate that there are factors that can preserve the mechanical properties even if the porosity of the scaffold increases. Therefore, in this study, various parameters affecting the porous and mechanical properties of the scaffolds during the manufacturing process were analyzed. It is expected that the improvement in the mechanical properties of the artificial bone scaffold having a high porosity can be applied to tissue engineering.

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“…2). Peri-fracture bone resorption and demineralization of cortical bone have also been previously reported in preclinical and clinical studies and were associated with stiff fixation leading to stress shielding of the bone 25,26 . Our recently developed time-lapsed in vivo micro-CT monitoring approach therefore allowed to precisely characterize the spatio-temporal changes in structural and dynamic callus parameters preceding non-unions.…”

Section: Discussionmentioning

confidence: 73%

Longitudinal in vivo micro-CT-based approach allows spatio-temporal characterization of fracture healing patterns and assessment of biomaterials in mouse femur defect models

Wehrle

Betts

Kuhn

et al. 2020

Preprint

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Thorough preclinical evaluation of novel biomaterials for treatment of large bone defects is essential prior to clinical application. Using in vivo micro-computed tomography (micro-CT) and mouse femoral defect models with different defect sizes, we were able to detect spatio-temporal healing patterns indicative of physiological and impaired healing in three defect sub-volumes and the adjacent cortex. The time-lapsed in vivo micro-CT-based approach was then applied to evaluate the bone regeneration potential of biomaterials using collagen and BMP-2 as test materials. Both collagen and BMP-2 treatment led to distinct changes in bone turnover in the different healing phases. Despite increased periosteal bone formation, 87.5% of the defects treated with collagen scaffolds resulted in non-unions. Additional BMP-2 application significantly accelerated the healing process and increased the union rate to 100%. This study further shows potential of time-lapsed in vivo micro-CT for capturing spatio-temporal deviations preceding non-union formation and how this can be prevented by application of biomaterials.This study therefore supports the application of longitudinal in vivo micro-CT for discrimination of normal and disturbed healing patterns and for the spatio-temporal characterization of the bone regeneration capacity of biomaterials.

show abstract

Topology Optimization to Reduce the Stress Shielding Effect for Orthopedic Applications

Cited by 65 publications

References 16 publications

Spatio-temporal characterization of fracture healing patterns and assessment of biomaterials by time-lapsed in vivo micro-computed tomography

Spatio-temporal characterization of fracture healing patterns and assessment of biomaterials by time-lapsed in vivo micro-computed tomography

Evaluation of Structural and Mechanical Properties of Porous Artificial Bone Scaffolds Fabricated via Advanced TBA-Based Freeze-Gel Casting Technique

Longitudinal in vivo micro-CT-based approach allows spatio-temporal characterization of fracture healing patterns and assessment of biomaterials in mouse femur defect models

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